 | | Vol. 13.25 – 8 July, 2021 |
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| Researchers interrogated the function of RNA-binding proteins (RBPs) in cancer using pooled CRISPR-Cas9 screening and identified 57 RBP candidates with distinct roles in supporting MYC-driven oncogenic pathways in TNBC cells.
[Molecular Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Trastuzumab-phage-like particles bound to the oncogenically active human epidermal growth factor receptor 2 (HER2) and were internalized by breast cancer cells of the HER2 overexpression subtype, but not by those lacking the HER2 amplification.
[ACS Nano] |
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| The authors reported a novel function of factor Kinectin 1 (KTN1) as a carcinogenic promoter in TNBC. KTN1 expression in TNBC was increased compared with adjacent tissues or luminal or HER2 subtypes of breast cancer, and TNBC patients with high KTN1 expression had poor prognoses.
[Signal Transduction and Targeted Therapy] |
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| Investigators optimized the use of optical barcoding to visualize and characterize 31 TNBC subclones in vivo.
[Science Advances] |
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| Mammary tumor cells were inoculated into the mammary fat pad and tibia. The role of Lrp5-mediated Wnt signaling was examined by overexpressing and silencing Lrp5 in osteocytes and establishing a conditional knockout mouse model.
[Bone Research] |
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| Fibrotic-like matrix stiffness promoted distinct metastatic phenotypes in breast cancer cells, which were preserved after transition to softer microenvironments, such as bone marrow.
[Cell Reports] |
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| Scientists described the role of the long non-coding RNA SPRY4 intronic transcript 1 (SPRY4-IT1) in cancer metastasis by mechanisms related to Staufen1-mediated mRNA decay and found that high SPRY4-IT1 expression was associated with aggressiveness and poor outcome in human colorectal, breast, and ovarian cancer tissues.
[Oncogene] |
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| The authors identified a novel long non-coding RNA AC073352.1 that was significantly upregulated in breast cancer tissues and was associated with advanced TNM stages and poor prognosis in breast cancer patients.
[Cell Death & Disease] |
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| Using a novel approach in estrogen receptor-positive (ER+) and negative breast cancer, researchers identified perinuclear-localized expression of STING in ER+ cases as an independent predictor of good prognosis, associated with immune cell infiltration and upregulation of immune checkpoints.
[npj Breast Cancer] |
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| Investigators found that QAP14 inhibited colony formation, cell motility, mammosphere formation and cancer stem-like cell (CSC) frequency, induced CSC apoptosis and dopamine D1 receptor expression, and increased cAMP/cGMP levels.
[Acta Pharmacologica Sinica] |
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| Scientists identified the potential role of SAMD4A in modulating angiogenesis-related genes expression and tumor progression in breast cancer. SAMD4A expression was repressed in breast cancer tissues and cells, and low SAMD4A expression in human breast tumor samples was strongly associated with poor survival of patients.
[Cancer Science] |
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| The authors indicated that cancer stem cells (CSCs) may enjoy blood perfusion to maintain their stemness features. Targeting the lysophosphatidic acid/protein kinase D-CD36 signaling pathway may have therapeutic potential to curb tumor progression by disrupting the arteriolar niche and effectively eliminating CSCs.
[Communications Biology] |
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| The roles of small extracellular vesicles (sEVs) from cancer-associated fibroblasts on breast cancer stem cell properties are largely unraveled. Researchers explored the roles of sEVs from cancer-associated fibroblasts on breast cancer progression.
[Cell Death Discovery] |
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| Investigators review the current findings on the potential of circular RNAs (circRNAs) as a diagnostic, prognostic, and therapeutic biomarker for TNBC, and discuss the current limitations and future directions of TNBC-associated circRNAs, which can facilitate the translation of experimental research into clinical application.
[Molecular Therapy-Nucleic Acids] |
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| Scientists discuss the emerging details on mutation in cancer that are now providing a wealth of new information on the roles played by estrogen receptor alpha, GATA3, and FOXA1 in regulating gene transcription and how their combined action contributes to a network shaping cell function in both physiologic and disease states.
[Current Opinion in Structural Biology] |
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| The authors outline progress surrounding the molecular mechanisms involved in breast cancer brain metastasis, experimental methods and research models to better understand the process, and provide an overview of current therapies and innovative research towards developing novel efficacious targeted therapies.
[British Journal of Cancer] |
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| Polyphor AG announced that its global Phase III study, FORTRESS, evaluating balixafortide in combination with eribulin for the treatment of patients with HER2 negative, locally recurrent or metastatic breast cancer, did not meet its co-primary endpoint.
[Polyphor AG] |
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| Results from a partnership to address disparities and enhance the quality of breast cancer care at Memphis-based West Cancer Center & Research Institute were announced.
[Rabble Health (PR Newswire, Inc.)] |
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| Knight Therapeutics, Inc. announced that Health Canada has approved NERLYNX® in combination with capecitabine for the treatment of adult patients with metastatic HER2-overexpressed/amplified breast cancer, who have received two or more prior anti-HER2-based regimens in the metastatic setting. The approval was based on results of the global Phase III NALA trial.
[Knight Therapeutics, Inc.] |
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| July 13 – 15, 2021
Virtual |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Mayo Clinic Health System – Rochester, Minnesota, United States |
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| | Institute of Oncology Research – Bellinzona, Switzerland |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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