 | | Vol. 13.36 – 23 September, 2021 |
| |
|
|
| Scientists showed that nuclear envelope ruptures induced DNA damage that promoted senescence in non-transformed cells and induced an invasive phenotype in human breast cancer cells.
[Cell] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Reduced representation bisulfite sequencing profiles of 1538 breast tumors and 244 normal breast tissues from the METABRIC cohort were reported, facilitating detailed analysis of DNA methylation within a rich context of genomic, transcriptional, and clinical data.
[Nature Communications] |
|
|
|
| Researchers developed a statistical framework to analyze extensive ChIP-seq and GWAS data, identified 22 breast cancer risk-associated transcription factors (TFs), and showed that FOXA1 and co-factors formed a core TF-transcriptional network regulating the susceptibility genes.
[Nature Communications] |
|
|
|
| Using inducible-shRNAs in TNBC and HER2+ breast-brain metastatic models researchers assessed IL13Rα2 function in vitro and in vivo.
[Clinical Cancer Research] |
|
|
|
| Investigators showed that the novel oncogene RASSF1C drove mesenchymal-to-amoeboid transition and stem cell attributed in breast cancer cells. Mechanistically, RASSF1C activated Rho/ROCK via SRC-mediated RhoGDI inhibition, resulting in generation of actomyosin contractility.
[EMBO Journal] |
|
|
|
| From in vitro and in vivo studies, scientists concluded that Iminodibenzyl could reprogram COX-2 induced DGLA peroxidation to produce anti-cancer activity.
[npj Breast Cancer] |
|
|
|
| To find metastatic recurrence biomarkers of TNBC treated by neoadjuvant chemotherapy and anti-EGFR antibodies, investigators evaluated tumor genomic, transcriptomic, and immune features, using MSK-IMPACT assay, gene arrays, Nanostring technology, and TIL assessment on H&E.
[npj Breast Cancer] |
|
|
|
| Scientists explored the role of MTDH in regulating the sensitivity of breast cancer cell lines to gemcitabine and the potential miRNAs targeting MTDH.
[Cell Death & Disease] |
|
|
|
| By using high-dimensional single-cell technologies, scientists identified heterogeneous behavior within the tissue-resident memory CD8+ T cells infiltrating luminal-like tumors.
[Communications Biology] |
|
|
|
| Investigators identified the oncogenic features of TNFSF4 in breast carcinoma. TNFSF4 was revealed to be closely related to treatment that induced antitumor immunity and to interact with multiple immune effector molecules and T cell signatures
[Scientific Reports] |
|
|
|
| Researchers analyzed mRNA expression profiles and the prognostic value of 43 genes involved in cell polarity, cell-adhesion and epithelial–mesenchymal transition in invasive micropapillary carcinoma of the breast tumors and compared them to invasive breast carcinomas of no special type.
[Scientific Reports] |
|
|
|
| The authors showed that histologically normal breast tissue from younger women who were susceptible to breast cancer, as a result of harboring a germline mutation in BRCA1, BRCA2or PALB2 genes, exhibited hallmarks of accelerated aging.
[Nature Aging] |
|
|
|
|
| Scientists focus on the basic characteristics of tRNA-derived small RNAs (tsRNAs), and their biological functions known thus far, and explored the regulatory roles of tsRNAs in cancer hallmarks including proliferation, apoptosis, metastasis, tumor microenvironment, drug resistance, cancer stem cell phenotype, and cancer cell metabolism.
[Cell Death Discovery] |
|
|
|
|
| Accutar Biotechnology, Inc. announced that the FDA has cleared the company’s investigational new drug application (IND) for AC0682 for the treatment of patients with estrogen receptor (ER)-positive breast cancers.
[Accutar Biotechnology, Inc.] |
|
|
|
|
| October 5 – 6, 2021
Virtual |
|
|
|
|
|
| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
|
|
|
| | Weill Cornell Medicine – New York, New York, United States |
|
|
|
| | Dalhousie University – Halifax, Nova Scotia, Canada |
|
|
|
| | Moores Cancer Center, UC San Diego – San Diego, California, United States |
|
|
|
| | University of South Carolina – Columbia – Columbia, South Carolina, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
