| Vol. 13.43 – 25 November, 2021 |
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| Researchers described a human inflammatory breast cancer (IBC) cell line, A3250, that recapitulated key IBC features in a mouse xenograft model, including skin erythema, diffuse tumor growth, dermal lymphatic invasion, and extensive metastases. [Nature Communications] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Estrogen receptor alpha (ERα) plays a vital role in the development of normal breast tissue and in breast cancer. Scientists cross-analyzed The Cancer Genome Atlas database and identified ERα-regulated long noncoding RNA 1 (ERLC1) as a long noncoding RNA exhibiting high specificity of expression in breast tissue. [Cancer Research] |
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| Investigators found that F-box and leucine-rich repeat protein 16 (FBXL16) acted as a tumor suppressor in TNBCs. FBXL16 directly bound to HIF1α and induced its ubiquitination and degradation, regardless of the tumor microenvironment, resulting in angiogenesis features of breast cancer. [Cell Reports] |
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| The authors showed that transmembrane protein 201 (TMEM201), as a positive modulator, was both necessary and sufficient to regulate the migration and invasion of breast cancer cells in vitro and in vivo. [Oncogene] |
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| Researchers found that primary human adipocytes shed extracellular vesicles, specifically exosomes, that induced the expression of genes associated with epithelial-to-mesenchymal transition and cancer stem–like cell traits in cocultured breast cancer cell lines. [Science Signaling] |
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| Investigators tested the hypothesis that metabolic stress induced breast cancer stem-like cell (BCSC) phenotype in TNBC. They found that serum/glucose deprivation not only increased stress markers but also enhanced GD2+ BCSC phenotype and function in TNBC cells. [British Journal of Cancer] |
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| Scientists explored sulfated glycosaminoglycan (sGAG) levels as a predictor of TNBC response to platinum therapy. sGAG levels were quantified in three distinct TNBC tumor models including cell line-derived, patient-derived xenograft tumors, and isogenic models deficient in sGAG biosynthesis. [Molecular Cancer therapeutics] |
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| Researchers developed a pipeline for Multi-Sample long-read Transcriptome Assembly, which enabled construction of a transcriptome from long-read sequence data. Using the constructed transcriptome as a reference, they analyzed RNA extracted from 22 clinical breast cancer specimens. [Communications Biology] |
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| The authors evaluated the inhibitory activity of the chimeric protein against breast cancer cells in vitro and in vivo. They developed a novel multifunctional protein, consisting of p28, as a tumor-homing killer peptide fused to apoptin as a tumor-selective killer. [Proteins-Structure Function and Bioinformatics] |
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| Prostate cancer-associated transcript 18 (PCAT18) was expressed at low levels in TNBC, and PCAT18 could sponge miR-103a-3p and promote activating transcription factor 7 expression, resulting in the prevention of TNBC metastasis. [Bioengineered] |
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| Scientists summarize current clinical trials, which assessed the safety and efficacy of breast cancer stem cells (BCSCs)-related therapies. [Journal of Experimental & Clinical Cancer Research] |
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| The authors conduct a meta-analysis, showing that the addition of programmed death-1/programmed death ligand-1 (PD-L1) blockade to chemotherapy improves progression-free survival in PD-L1 positive metastatic TNBC patients, and in the intention-to-treat population. [Critical Reviews in Oncology Hematology] |
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| | Gilead Sciences, Inc. announced that the European Commission has granted marketing authorization for Trodelvy® as a monotherapy indicated for the treatment of adult patients with unresectable or metastatic TNBC who have received two or more prior systemic therapies. [Gilead Sciences, Inc.] |
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| | | December 7 – 10, 2021 San Antonio, Texas, United States & Online |
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| | | | University of Copenhagen – Copenhagen, Denmark |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | University of Bergen – Bergen, Norway |
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| | University of Maryland School of Medicine – Baltimore, Maryland, United States |
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| | Georgetown University School of Medicine – Washington, District of Columbia, United States |
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