Mammary Cell News Volume 13.43 | Nov 25 2021

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    2021-11-25 | MCN 13.43


    Mammary Cell News by STEMCELL Technologies
    Vol. 13.43 – 25 November, 2021
    TOP STORY

    High Endogenous CCL2 Expression Promotes the Aggressive Phenotype of Human Inflammatory Breast Cancer

    Researchers described a human inflammatory breast cancer (IBC) cell line, A3250, that recapitulated key IBC features in a mouse xenograft model, including skin erythema, diffuse tumor growth, dermal lymphatic invasion, and extensive metastases.
    [Nature Communications]

    Full Article
    Virtual Conference Exhibition: Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    Analysis of the Estrogen Receptor-Associated lncRNA Landscape Identifies a Role for ERLC1 in Breast Cancer Progression

    Estrogen receptor alpha (ERα) plays a vital role in the development of normal breast tissue and in breast cancer. Scientists cross-analyzed The Cancer Genome Atlas database and identified ERα-regulated long noncoding RNA 1 (ERLC1) as a long noncoding RNA exhibiting high specificity of expression in breast tissue.
    [Cancer Research]

    Abstract

    Suppression of Breast Cancer Progression by FBXL16 via Oxygen-Independent Regulation of HIF1α Stability

    Investigators found that F-box and leucine-rich repeat protein 16 (FBXL16) acted as a tumor suppressor in TNBCs. FBXL16 directly bound to HIF1α and induced its ubiquitination and degradation, regardless of the tumor microenvironment, resulting in angiogenesis features of breast cancer.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Inner Nuclear Membrane Protein TMEM201 Promotes Breast Cancer Metastasis by Positive Regulating TGFβ Signaling

    The authors showed that transmembrane protein 201 (TMEM201), as a positive modulator, was both necessary and sufficient to regulate the migration and invasion of breast cancer cells in vitro and in vivo.
    [Oncogene]

    Abstract

    Adipocyte-Derived Exosomes May Promote Breast Cancer Progression in Type 2 Diabetes

    Researchers found that primary human adipocytes shed extracellular vesicles, specifically exosomes, that induced the expression of genes associated with epithelial-to-mesenchymal transition and cancer stem–like cell traits in cocultured breast cancer cell lines.
    [Science Signaling]

    AbstractPress Release

    Metabolic Stress Induces GD2+ Cancer Stem Cell-Like Phenotype in Triple-Negative Breast Cancer

    Investigators tested the hypothesis that metabolic stress induced breast cancer stem-like cell (BCSC) phenotype in TNBC. They found that serum/glucose deprivation not only increased stress markers but also enhanced GD2+ BCSC phenotype and function in TNBC cells.
    [British Journal of Cancer]

    Abstract

    Exploitation of Sulfated Glycosaminoglycan Status for Precision Medicine of Triplatin in Triple-Negative Breast Cancer

    Scientists explored sulfated glycosaminoglycan (sGAG) levels as a predictor of TNBC response to platinum therapy. sGAG levels were quantified in three distinct TNBC tumor models including cell line-derived, patient-derived xenograft tumors, and isogenic models deficient in sGAG biosynthesis.
    [Molecular Cancer therapeutics]

    Abstract

    Transcript-Targeted Analysis Reveals Isoform Alterations and Double-Hop Fusions in Breast Cancer

    Researchers developed a pipeline for Multi-Sample long-read Transcriptome Assembly, which enabled construction of a transcriptome from long-read sequence data. Using the constructed transcriptome as a reference, they analyzed RNA extracted from 22 clinical breast cancer specimens.
    [Communications Biology]

    Full Article

    A Novel Chimeric Protein with Enhanced Cytotoxic Effects on Breast Cancer In Vitro and In Vivo

    The authors evaluated the inhibitory activity of the chimeric protein against breast cancer cells in vitro and in vivo. They developed a novel multifunctional protein, consisting of p28, as a tumor-homing killer peptide fused to apoptin as a tumor-selective killer.
    [Proteins-Structure Function and Bioinformatics]

    Abstract

    lncRNA Prostate Cancer-Associated Transcript 18 Upregulates Activating Transcription Factor 7 to Prevent Metastasis of Triple-Negative Breast Cancer via Sponging miR-103a-3p

    Prostate cancer-associated transcript 18 (PCAT18) was expressed at low levels in TNBC, and PCAT18 could sponge miR-103a-3p and promote activating transcription factor 7 expression, resulting in the prevention of TNBC metastasis.
    [Bioengineered]

    Full ArticleGraphical Abstract
    How to prioritize and manage your research projects
    REVIEWS

    Heterogeneity of BCSCs Contributes to the Metastatic Organotropism of Breast Cancer

    Scientists summarize current clinical trials, which assessed the safety and efficacy of breast cancer stem cells (BCSCs)-related therapies.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Addition of Immunotherapy to Chemotherapy for Metastatic Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

    The authors conduct a meta-analysis, showing that the addition of programmed death-1/programmed death ligand-1 (PD-L1) blockade to chemotherapy improves progression-free survival in PD-L1 positive metastatic TNBC patients, and in the intention-to-treat population.
    [Critical Reviews in Oncology Hematology]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Trodelvy® (sacituzumab govitecan) Granted European Commission Marketing Authorization for Treatment of Metastatic Triple-Negative Breast Cancer in Second Line

    Gilead Sciences, Inc. announced that the European Commission has granted marketing authorization for Trodelvy® as a monotherapy indicated for the treatment of adult patients with unresectable or metastatic TNBC who have received two or more prior systemic therapies.
    [Gilead Sciences, Inc.]

    Press Release
    FEATURED EVENT

    San Antonio Breast Cancer Symposium

    December 7 – 10, 2021
    San Antonio, Texas, United States & Online

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Molecular Cancer Research

    University of Copenhagen – Copenhagen, Denmark

    Postdoctoral Fellow – Translational Cancer Research

    Icahn School of Medicine at Mount Sinai – New York City, New York, United States

    Postdoctoral Research Fellow – Cancer Biomarkers

    University of Bergen – Bergen, Norway

    Faculty Position – Hormone-Related Cancers

    University of Maryland School of Medicine – Baltimore, Maryland, United States

    Postdoctoral Fellow – Cancer Biology

    Georgetown University School of Medicine – Washington, District of Columbia, United States

    > See All Jobs

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