 | | Vol. 14.01 – 13 January, 2022 |
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| Scientists identified a lectin, SLBR-N, which bound to O-linked α2,3 sialic acids, that was able to enrich for cancer stem cells (CSCs) in vitro and in vivo. This O-glycan was expressed on CD44 and promoted its interaction with hyaluronic acid, facilitating CD44 signaling and CSC properties.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that a large subset of TNBC expressed significant levels of MAPK4, and this expression was critical for driving AKT activation independent of PI3K and promoting TNBC cell and xenograft growth.
[Nature Communications] |
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| Investigators demonstrated that obesity-associated tumor formation was driven by cellular adaptation rather than expansion of pre-existing clones within the cancer cell population.
[Nature Communications] |
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| The authors investigated breast cancer cell metabolism reprogramming by circular RNAs (circRNAs) from breast cancer stem cell (BCSC) exosomes and found that BCSC exosome-derived circCARM1 played an important role in breast cancer cell glycolysis by sponging miR-1252-5p.
[Oncogene] |
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| Scientists indicated that NONO enhanced nuclear epidermal growth factor receptor (EGFR)-mediated tumorigenesis and may be a potential therapeutic target for TNBC patients with nuclear EGFR expression.
[Cell Death & Disease] |
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| Knockdown of MnSOD inhibited TNBC cell invasion, breast cancer stem cells, mitochondrial reactive oxygen species, and interleukin-6 excretion promoted by multiple copies in T cell malignancy-1.
[Cell Death & Disease] |
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| Investigators demonstrated that endoplasmic reticulum stress could decrease androgen receptor mRNA and protein levels via PERK/eIF2α/ATF4 signaling in luminal androgen receptor TNBC and prostate cancer.
[npj Breast Cancer] |
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| The authors characterized a population of stem-like breast cancer cells expressing the integrin αvβ3 as transcriptionally related to activated stem/basal cells in the normal human mammary gland.
[npj Breast Cancer] |
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| Using MCF10A as a model of non-tumorigenic epithelial breast cells, scientists found that silencing KDM6A promoted cell migration and transformation demonstrated by the formation of tumor-like acini in 3D culture.
[Molecular Cancer Research] |
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| Researchers elucidated the underlying mechanism by which lncRNA UCA1 affected the m6A modification of miR-375 by mediating the DNA methylation of METTL14 and then altering SOX12 expression in breast cancer.
[Cancer Gene Therapy] |
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| Scientists discuss the latest developments in breast cancer stem cells (BCSCs) research, focusing on the analysis of specific markers, critical signaling pathways that maintain the stemness of BCSCs, such as NOTCH, Wnt/β-catenin, STAT3, Hedgehog, and Hippo-YAP signaling.
[Biomedicine & Pharmacotherapy] |
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| The authors summarize various ion channels and transporters associated with HER2-positive breast cancer and suggest potential targets for the development of new and effective therapies.
[Cancer Gene Therapy] |
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| Investigators evaluate the impact of dietary trace element intake in relation to the incidence of breast cancer and focus on five trace elements, thus emphasizing dietary selenium, zinc, iron, copper, and cadmium intake and risk of breast cancer.
[Biological Trace Element Research] |
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| Veru, Inc. announced that the US FDA has granted Fast Track designation to the Phase III registration program for the investigation of enobosarm for the treatment of androgen receptor positive, estrogen receptor positive, human epidermal growth factor receptor 2 negative (AR+ER+HER2-) metastatic breast cancer patients.
[Veru, Inc.] |
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| February 10 – 12, 2022
Lorne, Victoria, Australia |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | Charity-University Medicine Berlin – Berlin, Germany |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Leiden University – Leiden, United Kingdom |
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| | The University of Manchester – Manchester, United Kingdom |
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