CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH
Protease-Activated Receptors Mediate Cross-Talk Between Coagulation and Fibrinolysis
Researchers compared the protease-activated receptor-dependent expression of urokinase plasminogen activator and plasminogen activator inhibitor-1 in two murine mammary adencocarcinoma cell lines: metastatic 4T1 cells and non-metastatic 67NR cells. [Blood]
RNA Helicase A is a DNA-Binding Partner for EGFR-Mediated Transcriptional Activation in the Nucleus
Consistently, researchers observed a positive correlation of the nuclear expression of EGFR, RHA, and cyclin D1 in human breast cancer samples. [Proc Natl Acad Sci U S A]
Synergistic Chemosensitivity of Triple-Negative Breast Cancer Cell Lines to PARP Inhibition, Gemcitabine and Cisplatin
BRCA1 mutant cells exhibit sensitivity to gemcitabine, cisplatin and PARP inhibition, therefore, researchers hypothesized that triple negative cancer cells may also exhibit sensitivity to these drugs. [Cancer Res]
Secreted and Membrane-Bound Isoforms of Protease ADAM9 Have Opposing Effects on Breast Cancer Cell Migration
In this study, researchers show that ADAM9-S, a secreted variant, promotes breast cancer cell migration in a manner requiring its metalloprotease activity, whereas ADAM9-L, a transmembrane protein, suppresses cell migration independent of its metalloprotease activity. [Cancer Res]
Transforming Growth Factor-Beta-Induced Epithelial-Mesenchymal Transition Facilitates Epidermal Growth Factor-Dependent Breast Cancer Progression
Researchers show in this study that murine metastatic 4T1 breast cancer cells formed compact and dense spheroids when cultured under three-dimensional conditions, which was in sharp contrast to the branching phenotypes exhibited by their nonmetastatic counterparts. [Oncogene]
ITF2 is a Target of CXCR4 in MDA-MB-231 Breast Cancer Cells and is Associated with Reduced Survival in Estrogen Receptor-Negative Breast Cancer
Researchers propose that ITF2 is one of the CXCR4 targets, which is involved in CXCR4-dependent tumor growth and invasion of breast cancer cells. [Cancer Biol Ther]
CLINICAL RESEARCH
Alcohol Consumption and Breast Cancer Recurrence and Survival Among Women With Early-Stage Breast Cancer: The Life After Cancer Epidemiology Study
The purpose of this study was to examine the association of alcohol consumption after breast cancer diagnosis with recurrence and mortality among early-stage breast cancer survivors. [J Clin Oncol]
Molecular Anatomy of Breast Cancer Stroma and Its Prognostic Value in Estrogen Receptor-Positive and -Negative Cancers
The purpose of this study was to identify genes enriched in breast cancer stroma, assess the stromal gene expression differences between estrogen receptor (ER) -positive and -negative cancers, and separately determine their prognostic value in these two subtypes of breast cancers. [J Clin Oncol]
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POLICY NEWS
Roche, Genentech Hit with Refuse-to-File Letter
The FDA has handed Roche and Genentech a refuse-to-file letter for the developers’ BLA for trastuzumab-DM1. [Food and Drug Administration, United States]
NIH Director Collins Says Cell Ruling Won’t Halt Most Ongoing Grants
National Institutes of Health (NIH) Director Francis Collins said that the court injunction blocking federally funded research on human embryonic stem cells will not affect grant payments that have already gone out the door this year. [National Institutes of Health, United States]
NIH Director’s Response to Stem Cell Injunction [National Institutes of Health, United States]
Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20861) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-21357) [National Institutes of Health, United States]
National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-21282) [National Institutes of Health, United States]
National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-21317) [National Institutes of Health, United States]
National Human Genome Research Institute; Notice of Meetings (FR Doc. 2010-20858) [National Institutes of Health, United States]
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EVENTS (Listed by Date)
Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States
15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France
Cellular Therapy of Cancer Symposium – ATTACK Project Meeting
September 24-27, 2010
Montpellier, France
International Society for Cellular Therapy 2nd Annual Symposium on Stem Cell Translation: Best Practices & Regulatory Considerations
September 27-28, 2010
San Francisco, United States
Expert Perspectives: Integrating New Data into Best Practices for Breast Cancer
October 1, 2010
National Harbor, United States
2010 Breast Cancer Symposium
October 1-3, 2010
Washington, DC, United States
2nd International Inflammatory Breast Cancer Conference
October 6-7, 2010
Marseille, France
35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy
New York Stem Cell Foundation Fifth Annual Translational Stem Cell Research Meeting
October 12-13, 2010
New York, United States
International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States
16th World Congress of the International Society of Senology
October 20-22, 2010
Valencia, Spain
The 2010 American Institute for Cancer Research (AICR) Annual Research Conference on Food, Nutrition, Physical Activity & Cancer
October 21-22, 2010
Washington, DC, United States
MENA Oncology Conference
October 22-23, 2010
Cairo, Egypt
UAE Cancer Congress 2010
October 28-30, 2010
Dubai, United Arab Emirates
6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom
22nd EORTC-NCI-AACR Symposium on “Molecular Targets and Cancer Therapeutics”
November 16-19, 2010
Berlin, Germany
33rd Annual San Antonio Breast Cancer Symposium
December 8-12, 2010
San Antonio, United States
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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