Mammary Cell News Volume 3.47 | Dec 1 2011

May 12, 2022

Mammary Cell News 3.47, December 1, 2011

In this issue: Publications | Industry News | Policy News | Events | Jobs

TOP STORY

Role of JNK in Mammary Gland Development and Breast Cancer
In this study scientists employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary gland to evaluate the requirement for these ubiquitously expressed genes in breast development and tumorigenesis. [Cancer Res] Abstract

PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Mechanistic Modeling of the Effects of Myoferlin on Tumor Cell Invasion
In this paper, scientists demonstrate that myoferlin plays a previously unrecognized role in cancer cell invasion, using a combination of mathematical modeling and in vitro experiments. [Proc Natl Acad Sci USA] Abstract

BRCA1 and GATA3 Corepress FOXC1 to Inhibit the Pathogenesis of Basal-Like Breast Cancers
Researchers describe a novel interaction between the breast/ovarian tumor suppressor gene BRCA1 and the transcription factor GATA3, an interaction which is important for normal breast differentiation. [Oncogene] Abstract

Adenosine A_2B Receptor Blockade Slows Growth of Bladder and Breast Tumors
In this study, investigators evaluated the effects of intermittent intratumor injection of a nonselective adenosine receptor antagonist, aminophylline and a selective A_2B receptor antagonist, ATL801. [J Immunol] Abstract

The Insulin-Like Growth Factor-I Receptor (IGF-IR) Translocates to the Nucleus and Autoregulates IGF-IR Gene Expression in Breast Cancer Cells
The present study was aimed at investigating: (1) the putative translocation of IGF-IR and the related insulin receptor (IR) to the nucleus in breast cancer cells; (2) the impact of IGF-IR and IR levels on IGF-IR biosynthesis in estrogen receptor (ER)-positive and ER-depleted breast cancer cells; and (3) the potential transcription factor role of IGF-IR in the specific context of IGF-IR gene regulation. [J Biol Chem] Abstract

CDDO-Methyl Ester Delays Breast Cancer Development in Brca1-Mutated Mice
Because the methyl ester of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Me) is a potent chemopreventive agent, scientists tested its efficacy in a highly relevant mouse model of BRCA1-mutated breast cancer. [Cancer Prev Res] Abstract

Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression
To test the hypothesis that metformin might be reducing the risk to breast cancers, the human breast carcinoma cell line, MCF-7, grown in 3-dimensional mammospheres which represent human breast cancer stem cell population, were treated with various known and suspected breast cancer chemicals with and without non-cytotoxic concentrations of metformin. [PLoS One] Abstract | Press Release

Loss of the 14-3-3σ Tumor Suppressor Is a Critical Event in ErbB2-Mediated Tumor Progression
Researchers demonstrate that loss of one or both copies of the conditional 14-3-3σ allele results in accelerated mammary and salivary tumorigenesis in mice expressing an activated erbB2 oncogene under the endogenous erbB2 promoter. [Cancer Discov] Abstract | Press Release

CLINICAL RESEARCH

Prospective Study Evaluating the Impact of Tissue Confirmation of Metastatic Disease in Patients With Breast Cancer
This prospective study investigated receptor status of primary tumors and metastases in the same patient and assessed the impact of discordance on patient management and survival. [J Clin Oncol]
Abstract | Press Release

Loss of Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Metastatic Sites of HER2-Overexpressing Primary Breast Tumors
Scientists evaluated whether patients with HER2-positive primary breast tumors had metastatic tumors that were HER2 positive (concordant) or HER2 negative (discordant). [J Clin Oncol] Abstract

Breast Cancer Patients with Lobular Cancer More Commonly Have a Father than a Mother Diagnosed
The aim of the study was to identify new hereditary patterns predisposing for cancer in the different histopathologic subtypes of breast cancer, with focus on patients with lobular breast cancer and cancer in their first degree relatives. [BMC Cancer] Abstract | Press Release

INDUSTRY NEWS

Pioneering International Partnership Honored
Cardiff’s ground-breaking cancer research partnership work with China has won the International Collaboration category at the annual Times Higher Education awards. [Cardiff University]
Press Release

Major Cancer Stem Cell Appointment
Cardiff’s pioneering European Cancer Stem Cell Research Institute is to be greatly strengthened with the arrival of Dr Matt Smalley. [Cardiff University] Press Release

Penn Medicine Physicians Receive Five-Year, $7.5 Million Grant for Breast Cancer Screening Research
University of Pennsylvania (Penn) researchers have received a five-year, $7.5 million grant from the National Cancer Institute to create the Penn Center for Innovation in Personalized Breast Cancer Screening, dedicated to studying emerging methods of breast cancer detection. [University of Pennsylvania] Press Release

POLICY NEWS

Avastin Approval for Breast Cancer Pulled
Health Canada has revoked approval of Avastin as a treatment for metastatic breast cancer, following closely in the footsteps of the U.S. Food and Drug Administration. [Health Canada, Canada]
Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)