| PUBLICATIONS (Ranked by Impact Factor of the Journal) | LABORATORY RESEARCH Direct Regulation of MicroRNA Biogenesis and Expression by Estrogen Receptor ß in Hormone-Responsive Breast Cancer Considering the possibility that estrogen receptor ß (ERß) might influence breast cancer (BC) cell behavior via microRNAs (miRNAs), researchers compared miRNome expression in ERß+ vs ERß- hormone-responsive BC cells and found a widespread effect of this ER subtype on the expression pattern of these non-coding RNAs. [Oncogene] Abstract Hyperinsulinemia Enhances c-Myc-Mediated Mammary Tumor Development and Advances Metastatic Progression to the Lung in a Mouse Model of Type II Diabetes Using a hyperinsulinemic mouse model and the metastatic, c-Myc-transformed mammary carcinoma cell line Mvt1, researchers investigated how high systemic insulin levels would affect the progression of orthotopically inoculated primary mammary tumors to lung metastases. [Breast Cancer Res] Abstract Hypoxia Inducible Factor-1α Promotes Primary Tumor Growth and Tumor-Initiating Cell Activity in Breast Cancer Researchers investigated whether hypoxia inducible factor-1α is directly implicated in regulation of tumor-initiating cells in breast cancer. [Breast Cancer Res] Abstract Microcalcifications in Breast Cancer: Novel Insights into the Molecular Mechanism and Functional Consequence of Mammary Mineralization Researchers report a novel model to investigate the in vitro mineralization potential of a panel of mammary cell lines. [Br J Cancer] Abstract Impaired CK1δ Activity Attenuates SV40-Induced Cellular Transformation In Vitro and Mouse Mammary Carcinogenesis In Vivo Here researchers characterized the effects of mutant CK1δ variants with impaired kinase activity on simian virus 40 (SV40)-induced cell transformation in vitro, and on SV40-induced mammary carcinogenesis in vivo in a transgenic/bi-transgenic mouse model. [PLoS One] Abstract Small Interfering RNA Targeted to IGF-IR Delays Tumor Growth and Induces Proinflammatory Cytokines in a Mouse Breast Cancer Model The aim of this study was to determine whether an RNA interference approach targeted to insulin-like growth factor-1 receptor (IGF-IR) could be used for specific antitumor immunostimulation in a breast cancer model. [PLoS One] Abstract Bone Morphogenetic Protein (BMP) Signaling Regulates Mitotic Checkpoint Protein Levels in Human Breast Cancer Cells In the present study researchers show that, in human breast cancer cells, chemical inhibition of BMPs, but not transforming growth factor-β, abrogates the mitotic arrest induced by nocodazole. [Cell Signal] Abstract EphrinA1-EphA2 Interaction-Mediated Apoptosis and FMS-Like Tyrosine Kinase Receptor Ligand-Induced Immunotherapy Inhibits Tumor Growth in a Breast Cancer Mouse Model Researchers tested the EphrinA1-EphA2 interaction in MDA-MB-231 breast cancer cells focusing on the receptor-ligand-mediated apoptosis of breast cancer cells. [J Gene Med] Abstract CLINICAL RESEARCH Estrogen Metabolism and Risk of Breast Cancer in Postmenopausal Women In this study, researchers found nearly all estrogens, estrogen metabolites, and metabolic pathway groups were associated with an increased risk of breast cancer; the serum concentration of unconjugated estradiol was strongly associated with the risk of breast cancer. [J Natl Cancer Inst] Abstract Novel Genetic Markers of Breast Cancer Survival Identified by a Genome-Wide Association Study Here researchers report the identification of two SNPs associated with total mortality from a two-stage genome-wide association study conducted among 6,110 Shanghai-resident Chinese women with TNM stage I-IV breast cancer. [Cancer Res] Abstract |
| INDUSTRY NEWS | Galena Biopharma Announces Investigational New Drug Approval for Phase II Trial for NeuVaxTM (E75 + Granulocyte Macrophage Colony-Stimulating Factor) Combined with Herceptin® (Trastuzumab) Galena Biopharma announced that the U.S. Food and Drug Administration has been approved the Investigational New Drug application for the Phase II combination trial with NeuVax™ and Herceptin®. [Galena Biopharma] Press Release Eisai Inc. Receives J-Code from CMS for Halaven® (Eribulin Mesylate) Injection Eisai Inc. announced that the Centers for Medicare and Medicaid Services (CMS) has assigned a unique, permanent Healthcare Common Procedure Coding System J-code for Halaven® Injection. [Business Wire] Press Release UND Signs License to Develop Breakthrough Breast Cancer Detection Technology with Neomatrix, LLC The University of North Dakota (UND) and Neomatrix, LLC announced that they have signed an exclusive agreement to develop technology for the early detection of breast cancer using the company’s HALO® Breast Pap Test device. [The University of North Dakota School of Medicine & Health Sciences] Press Release Midatech Secures £6.3 Million Financing to Strengthen Product Development Portfolio Midatech Ltd. announced it has raised £6.3 million through a private investment round. This financing will be used to support clinical development of chemotherapeutic gold nanoparticles designed to target ovarian, lung and breast carcinoma. [Midatech Ltd.] Press Release OncoMed Pharmaceuticals Promotes Dr. Jakob Dupont to Chief Medical Officer OncoMed Pharmaceuticals, Inc. announced the promotion of Jakob Dupont, M.D., formerly Vice President, Clinical Research, to Senior Vice President and Chief Medical Officer. [OncoMed Pharmaceuticals, Inc.] Press Release AMGA Welcomes Four New Members to Board of Directors The American Medical Group Association (AMGA) announced the addition of four new members to its Board of Directors. [American Medical Group Association] Press Release |
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