LABORATORY RESEARCH Global MicroRNA Level Regulation of EGFR-Driven Cell-Cycle Protein Network in Breast Cancer Here, investigators combined a large-scale microRNA (miRNA) screening approach with a high-throughput proteomic readout and network-based data analysis to identify which miRNAs are involved in the EFGR protein network, and to uncover potential regulatory patterns. [Mol Syst Biol] Abstract Radiation-Induced Reprogramming of Breast Cancer Cells Using non-breast cancer stem cells (BCSCs) sorted from patient samples, researchers found that ionizing radiation reprogrammed differentiated breast cancer cells into induced BCSCs. [Stem Cells] Abstract | Press Release CD24−/low Stem-Like Breast Cancer Marker Defines the Radiation-Resistant Cells Involved in Memorization and Transmission of Radiation-Induced Genomic Instability Investigators searched the cancer stem cell markers associated to radiation-resistance in breast cancer cell lines and studied the role of the resistant cells in the transmission of genomic instability. [Oncogene] Abstract A Fatty Acid-Binding Protein 7/RXRβ Pathway Enhances Survival and Proliferation in Triple-Negative Breast Cancer In this study, researchers examine fatty acid binding protein 7 expression in a cohort of 176 primary breast cancers by gene profiling and tissue microarray immunostaining. [J Pathol] Abstract Mediator Subunits MED1 and MED24 Cooperatively Contribute to Pubertal Mammary Gland Development and Growth of Breast Carcinoma Cells Here, scientists provide evidence that the MED24-containing submodule of Mediator functionally communicates specifically with MED1 in pubertal mammary gland development. [Mol Cell Biol] Abstract Protein Pathway Activation Mapping Reveals Molecular Networks Associated with Anti-Estrogen Resistance in Breast Cancer Cell Lines Investigators postulated that changes in activation status of protein signaling networks induced by breast cancer anti-estrogen resistance genes may provide better insight into the mechanisms underlying anti-estrogen resistance. [Int J Cancer] Abstract The Unliganded Glucocorticoid Receptor Positively Regulates the Tumor Suppressor Gene BRCA1 through GABP Beta Here, researchers have identified a direct role for the unliganded glucocorticoid receptor in BRCA1 upregulation in the absence of hydrocortisone. [Mol Cancer Res] Abstract Monocytes Conditioned Media Stimulate Fibronectin Expression and Spreading of Inflammatory Breast Cancer Cells in Three-Dimensional Culture: A Mechanism Mediated by IL-8 Signaling Pathway The present study investigated the effect of media conditioned by human monocytes U937 secreted cytokines, chemokines and growth factors on the expression of adhesion molecules E-cadherin and fibronectin of human inflammatory breast cancer cell line SUM149. [Cell Commun Signal] Abstract | Press Release CLINICAL RESEARCH First-Line Treatment of Advanced Breast Cancer with Sunitinib in Combination with Docetaxel Versus Docetaxel Alone: Results of a Prospective, Randomized Phase III Study The purpose of this study is to investigate whether sunitinib plus docetaxel improves clinical outcomes for patients with human epidermal growth factor receptor 2/neu–negative advanced breast cancer versus docetaxel alone. [J Clin Oncol] Abstract Predictors of Aromatase Inhibitor Discontinuation as a Result of Treatment-Emergent Symptoms in Early-Stage Breast Cancer Women with early-stage breast cancer initiating aromatase inhibitor therapy were enrolled onto a multicenter, prospective, open-label randomized trial of exemestane versus letrozole. [J Clin Oncol] Abstract Phase III Trial Evaluating Weekly Paclitaxel Versus Docetaxel in Combination with Capecitabine in Operable Breast Cancer Scientists investigated whether capecitabine and docetaxel followed by fluorouracil, epirubicin, and cyclophosphamide (FEC) or weekly paclitaxel followed by FEC would improve relapse-free survival in operable breast cancer. [J Clin Oncol] Abstract BRCA1 Testing Should Be Offered to Individuals with Triple-Negative Breast Cancer Diagnosed Below 50 Years Researchers have evaluated the BRCA1 mutation frequency and the implications for clinical practice of undertaking genetic testing in women with triple-negative breast cancer. [Br J Cancer] Abstract | Press Release |