| PUBLICATIONS (Ranked by impact factor of the journal) | LABORATORY RESEARCH p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer Scientists showed that wild-type p53 activity hinders chemotherapy response and demonstrated the need to reassess the paradigm for p53 in cancer therapy. [Cancer Cell] Abstract | Press Release Implanted Adipose Progenitor Cells as Physicochemical Regulators of Breast Cancer Through the integration of physical sciences and oncology approaches, researchers investigated the capability of tumor-derived chemical and mechanical cues to enhance adipose-derived stem cell-mediated contributions to tumor stroma formation. [Proc Natl Acad Sci USA] Abstract MicroRNA93 Regulates Proliferation and Differentiation of Normal and Malignant Breast Stem Cells Using a series of breast cancer cell lines representing different stages of differentiation and mouse xenograft models, scientists demonstrated that microRNA93 modulates the fate of breast cancer stem cells by regulating their proliferation and differentiation states. [PLoS Genet] Full Article Overexpression of GOLPH3 Promotes Proliferation and Tumorigenicity in Breast Cancer via Suppression of the FOXO1 Transcription Factor The role of golgi phosphoprotein 3 (GOLPH3) in breast cancer cell proliferation and tumorigenicity was explored in vitro and in vivo. [Clin Cancer Res] Abstract MiR-21 Is Targeted by Omega-3 Polyunsaturated Fatty Acid to Regulate Breast Tumor CSF-1 Expression Researchers reveal a novel mechanism for the therapeutic function of fish oil diet which blocks microRNA-21 (miR-21); thereby increasing PTEN levels to prevent expression of CSF-1 (colony stimulating factor-1) in breast cancer. [Carcinogenesis] Abstract Targeting Facilitates Chromatin Transcription Complex Suppresses Mammary Tumorigenesis in Her2/Neu Transgenic Mice Researchers tested whether Curaxin-137 could suppress tumorigenesis in MMTV-neu transgenic mice, which spontaneously develop mammary carcinoma due to steroid receptor-regulated expression of the Her2 proto-oncogene. [Cancer Prev Res] Abstract CTGF Drives Autophagy, Glycolysis, and Senescence in Cancer Associated Fibroblasts via Hypoxia-Inducible Factor 1 Activation, Metabolically Promoting Tumor Growth Investigators shed new light on the compartment-specific role of connective tissue growth factor (CTGF) in mammary tumorigenesis, and provide novel insights into the mechanism(s) generating a lethal tumor microenvironment in patients lacking stromal caveolin-1. [Cell Cycle] Abstract A Targeted Enzyme Approach to Sensitization of Tyrosine Kinase Inhibitor-Resistant Breast Cancer Cells Epidermal growth factor receptor (EGFR) has been shown to be overexpressed in breast cancer, and in particular remains hyperphosphorylated in cell lines such as MDA-MB-468 that are resistant to EGFR inhibitors. Researchers investigated the cause of this sustained phosphorylation and the molecular basis for the ineffectiveness of gefitinib. [Exp Cell Res] Abstract CLINICAL RESEARCH Chemotherapy (CT) and Hormonotherapy (HT) as Neoadjuvant Treatment in Luminal Breast Cancer Patients: Results from the GEICAM/2006-03, a Multicenter, Randomized, Phase II Study Scientists investigated the value of CT and HT in luminal breast cancer patients in the neoadjuvant setting. [Ann Oncol] Abstract Mammaglobin-A cDNA Vaccination of Breast Cancer Patients Induces Antigen-Specific Cytotoxic CD4+ Inducible Co-Stimulatorhi T Cells Researchers present results on a phase I clinical trial of a mammaglobin-A cDNA vaccination in breast cancer patients with stage-IV metastatic disease, including the impact of vaccination on the expression of the inducible co-stimulator molecule on CD4 T cells. [Breast Cancer Res Treat] Abstract Randomized Phase II Study of Three Doses of Oral TAS-108 in Postmenopausal Patients with Metastatic Breast Cancer This randomized phase II study was intended to identify the optimal dose of TAS-108, a novel steroidal antiestrogen, for the treatment of breast cancer in postmenopausal Japanese women. [Cancer Sci] Abstract |
| SCIENCE NEWS | For Some Breast Cancers, New Drug May Be Treatment Option Results from an international clinical trial suggest that women with metastatic, HER2-positive breast cancer that is no longer responding to the targeted therapy trastuzumab may soon have a new treatment option. [Press release from the National Cancer Institute discussing research presented at the American Society of Clinical Oncology (ASCO) 2012 Annual Meeting, Chicago] Press Release Even Low Doses of Radiation in Childhood May Raise Breast Cancer Risk Dr. Chaya Moskowitz of Memorial Sloan-Kettering Cancer Center presented data from more than 1,200 women participating in the Childhood Cancer Survivor Study who received radiation to the chest as children, adolescents, or young adults. [Press release from the National Cancer Institute discussing research presented at the American Society of Clinical Oncology (ASCO) 2012 Annual Meeting, Chicago] Press Release Generex Announces Interviews Featuring the Antigen Express AE37 Breast Cancer Vaccine Generex Biotechnology Corporation announced that two interviews were conducted featuring the on-going Phase II clinical trial of the Antigen Express AE37 immunotherapeutic breast cancer vaccine. [Press release from Generex Biotechnology Corporation discussing interviews conducted at the American Society of Clinical Oncology (ASCO) 2012 Annual Meeting, Chicago] Press Release | Video 1 | Video 2 |
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