| PUBLICATIONS (Ranked by impact factor of the journal) | LABORATORY RESEARCH Inhibition of the Kit Ligand/c-Kit Axis Attenuates Metastasis in a Mouse Model Mimicking Local Breast Cancer Relapse after Radiotherapy Scientists used the well-characterized 4T1 syngeneic, orthotopic breast cancer model to identify novel mechanisms of post-radiation metastasis. [Clin Cancer Res] Abstract To Bind or Not to Bind – FoxA1 Determines Estrogen Receptor Action in Breast Cancer Progression Researchers aimed to determine the dynamics of estrogen receptor binding and differences between more and less aggressive primary breast tumors and metastases. [Breast Cancer Res] Abstract Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) Augments Binding of the c-Src Kinase SH3 Domain to Crk-Associated Substrate (p130Cas) Researchers showed that among NSP family members, only BCAR3 augments the ability of p130Cas to bind the Src SH3 domain through an RPLPSPP motif in the p130Cas Src-binding domain. [J Biol Chem] Abstract | Full Article MicroRNA-632 Downregulates DNAJB6 in Breast Cancer Scientists found that hsa-microRNA-632 (miR-632) targets the coding region of DNAJB6, and invasive and metastatic breast cancer cells express high levels of miR-632 compared with mammary epithelial cells. [Lab Invest] Abstract Breast Cancer Cell Targeting by Prenylation Inhibitors Elucidated in Living Animals with a Bioluminescence Reporter To determine which cell types can be targeted directly by distinct classes of prenylation inhibitors in vivo, researchers described the development and implementation of a sensitive and pharmacologically specific bioluminescence-based imaging reporter that is inducible by prenylation inhibitors. [Clin Cancer Res] Abstract LEF-1 Regulates Proliferation and MMP-7 Transcription in Breast Cancer Cells Investigators demonstrated that lymphoid enhancer binding factor-1 (LEF-1) is associated with regulation of the proliferation-associated cyclin D1 and a gene encoding matrix metalloproteinase-7 (MMP-7) in breast cancer cells. [Genes Cells] Abstract Frondoside A Has an Anti-Invasive Effect by Inhibiting TPA-Induced MMP-9 Activation via NF-κB and AP-1 Signaling in Human Breast Cancer Cells Researchers aimed to determine the anti-invasive activity of frondoside A against human breast cancer cells. They investigated the inhibitory effect of frondoside A on cell clonogenicity, invasion and migration in TPA-stimulated human breast cancer cells at non-cytotoxic concentrations. [Int J Oncol] Abstract RL71, a Second-Generation Curcumin Analog, Induces Apoptosis and Downregulates Akt in ER-Negative Breast Cancer Cells RL71 is a second-generation curcumin analog that exhibits potent cytotoxicity towards a variety of estrogen receptor (ER)-negative breast cancer cells. Researchers examined the mechanism of this anticancer activity in three different ER-negative breast cancer cell lines. [Int J Oncol] Abstract CLINICAL RESEARCH Clinically Used Breast Cancer Markers Such as Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 Are Unstable Throughout Tumor Progression Researchers investigated whether hormonal receptors and human epidermal growth factor receptor 2 change throughout tumor progression. [J Clin Oncol] Abstract Methylation of HIN-1, RASSF1A, RIL and CDH13 in Breast Cancer Is Associated with Clinical Characteristics, but Only RASSF1A Methylation Is Associated with Outcome To determine the impact of methylation on clinical outcome, researchers have conducted a large study with breast cancers for which time to first recurrence and overall survival are known. [BMC Cancer] Abstract |
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