LABORATORY RESEARCH An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer Scientists used integrative genomic analysis to identify candidate oncogenes in triple-negative breast tumors and assess their function through loss of function screening. They identified lactate dehydrogenase B (LDHB), a component of glycolytic metabolism, as an essential gene in triple-negative breast cancer. [Cancer Res] Abstract Simultaneous Inhibition of Metastasis and Growth of Breast Cancer by Co-Delivery of Twist shRNA and Paclitaxel Using Pluronic P85-PEI/TPGS Complex Nanoparticles An attempt to simultaneously inhibit the metastasis and growth of tumor by co-delivering Twist shRNA and paclitaxel using the conjugate of pluronic P85 (P85) and low molecular weight polyethyleneimine (PEI)/D-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) complex nanoparticles was performed on metastatic 4T1 breast cancer cell line and its pulmonary metastasis mice model. [Biomaterials] Abstract Flotillin-2 Deficiency Leads to Reduced Lung Metastases in a Mouse Breast Cancer Model Investigators identified flotillin-2 as highly amplified in a high-throughput comparative genomic hybridization screen of human breast cancer cell lines and breast tumor samples. Short hairpin RNA-mediated reduction of flotillin-2 protein levels significantly reduced the tumorigenicity and metastatic capability of a human breast cancer cell line in vivo. [Oncogene] Abstract Prospective Dual Role of Mesenchymal Stem Cells in Breast Tumor Microenvironment Researchers found that a distinct subset of breast resident, adipose tissue-derived mesenchymal stem cells display a strong affinity for conditioned media from two breast cancer cell lines, MDA-MB 231 and MCF-7. [Breast Cancer Res Treat] Abstract Embryonic Morphogen Nodal Promotes Breast Cancer Growth and Progression Scientists demonstrated that the human embryonic stem cell-associated factor Nodal promotes breast cancer growth. [PLoS One] Full Article Py2T Murine Breast Cancer Cells, a Versatile Model of TGFβ-Induced EMT In Vitro and In Vivo Researchers sought to generate a transplantable cellular model system that allows defined experimental manipulation and analysis of epithelial to mesenchymal transition (EMT) in vitro and at the same time recapitulates oncogenic EMT in vivo. [PLoS One] Full Article Curcuminoids Block Transforming Growth Factor-β Signaling in Human Breast Cancer Cells and Limit Osteolysis in a Murine Model of Breast Cancer Bone Metastasis Effects of curcuminoids on breast cancer cell secretion of the bone-resorptive peptide parathyroid hormone-related protein and on lytic breast cancer bone metastasis were evaluated. [J Nat Prod] Abstract CLINICAL RESEARCH A Multicenter, Phase I, Dose-Escalation Study to Assess the Safety, Tolerability and Pharmacokinetics of Etirinotecan Pegol in Patients with Refractory Solid Tumors This study was designed to establish the maximum-tolerated dose and to evaluate tolerability, pharmacokinetics, and antitumor activity of etirinotecan pegol. [Clin Cancer Res] Abstract Comparison of Mastoscopic and Conventional Axillary Lymph Node Dissection in Breast Cancer: Long-Term Results from a Randomized, Multicenter Trial A group of 1027 consecutive patients with operable breast cancer were randomly assigned to one of two study groups: mastoscopic axillary lymph node dissection and conventional axillary lymph node dissection. The median follow-up was 63 months. The primary end points of the study were operative outcomes, complication reduction, function conservation, and cosmetics. [Mayo Clin Proc] Abstract | Press Release |