LABORATORY RESEARCH WNT10B/β-Catenin Signaling Induces HMGA2 and Proliferation in Metastatic Triple-Negative Breast Cancer Scientists illustrate that WNT10B induces transcriptionally active β-catenin in human triple-negative breast cancers (TNBC) and predicts survival-outcome of patients with both TNBC and basal-like tumors. [EMBO Mol Med] Full Article KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival Researchers demonstrated that KLF6-SV1, an oncogenic splice variant of the KLF6 tumor suppressor gene, is associated with increased metastatic potential and poor survival in a cohort of 671 lymph node-negative breast cancer patients. KLF6-SV1 overexpression in mammary epithelial cell lines resulted in an epithelial-to-mesenchymal-like transition and drove aggressive multiorgan metastatic disease in multiple in vivo models. [Sci Transl Med] Abstract | Press Release Crosstalk between Lysine-Specific Demethylase 1 (LSD1) and Histone Deacetylases Mediates Antineoplastic Efficacy of HDAC Inhibitors in Human Breast Cancer Cells Scientists showed that knockdown of LSD1 expression by RNAi decreased mRNA levels of histone deacetylase (HDAC) isozymes in triple-negative breast cancer cells. [Carcinogenesis] Abstract Mitochondrial-Dependent Anticancer Activity of δ-Tocotrienol and Its Synthetic Derivatives in HER-2/neu Overexpressing Breast Adenocarcinoma Cells Anticancer activity and mitochondrial mechanism of the vitamin E form δ-tocotrienol was investigated in HER-2/neu-overexpressing human SKBR3 and murine TUBO breast cancer cells. [Biofactors] Abstract Lapatinib-Mediated Cyclooxygenase-2 Expression via EGFR/HuR Interaction Enhances the Aggressiveness of Triple-Negative Breast Cancer Cells The authors demonstrated that lapatinib facilitated axillary and lung metastases of triple-negative MDA-MB-231 breast cancer cells without affecting their viability, leading to worse survival in orthotopic xenograft mice. [Mol Pharmacol] Abstract Mesenchymal and Stem-Like Cell Properties Targeted in Suppression of Chronically-Induced Breast Cell Carcinogenesis The authors investigated stem-like cell- and epithelial-to-mesenchymal transition-associated properties and markers in breast epithelial cells chronically exposed to low-dose 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene in the presence and absence of the preventive agents green tea catechins and grape seed extract. [Cancer Lett] Abstract Phenotypic Switch in Blood: Effects of Pro-Inflammatory Cytokines on Breast Cancer Cell Aggregation and Adhesion Scientists hypothesized that human plasma, 3-D tumor spheroid culture, and cytokine-supplemented culture media could induce a phenotypic switch that allows breast cancer cells to interact with E-selectin coated surfaces under physiological flow. [PLoS One] Full Article | Press Release Antiproliferative Effects of Pomegranate Extract in MCF-7 Breast Cancer Cells Are Associated with Reduced DNA Repair Gene Expression and Induction of Double Strand Breaks While pomegranate extract (PE) is a potent antioxidant, researchers conducted studies to examine the mechanisms of action of PE beyond antioxidation by studying cellular and molecular mechanisms underlying breast tumorigenesis. [Mol Carcinog] Abstract CLINICAL RESEARCH Survival after Lumpectomy and Mastectomy for Early Stage Invasive Breast Cancer A large, population-based series of women who underwent breast-conserving therapy with radiation or mastectomy was studied to observe whether outcomes of randomized clinical trials were achieved in the general population, and whether survival differed by surgery type when stratified by age and hormone receptor status. [Cancer] Abstract | Press Release Associations of Serum 25-Hydroxyvitamin D with Overall and Breast Cancer-Specific Mortality in a Multiethnic Cohort of Breast Cancer Survivors In the Health, Eating, Activity, and Lifestyle study, investigators examined associations of post-treatment serum concentrations of 25-hydroxyvitamin D on overall and breast cancer-specific mortality in 585 breast cancer survivors. [Cancer Causes Control] Abstract |