| PUBLICATIONS (Ranked by impact factor of the journal) | LABORATORY RESEARCH Therapeutic Efficacy of Metronomic Chemotherapy with Cyclophosphamide and Doxorubicin on Murine Mammary Adenocarcinomas The authors investigated the therapeutic efficacy of metronomic cyclophosphamide combined with doxorubicin in two mouse mammary adenocarcinoma models. [Ann Oncol] Abstract Tumor Necrosis Factor Alpha Induced Warburg-Like Metabolism and Is Reversed by Anti-Inflammatory Curcumin in Breast Epithelial Cells Researchers illustrated that treatment of non-malignant and malignant breast epithelial cells with low-level tumor necrosis factor alpha significantly increased glycolytic reliance, lactate export, and expression of the glucose transporter, GLUT1. [Int J Cancer] Abstract The Expression and Significance of Insulin-Like Growth Factor-1 Receptor and Its Pathway on Breast Cancer Stem/Progenitors Cancer stem cells (CSCs) are a subpopulation within cancer cells which participate in tumor initiation, radio/chemoresistance and metastasis. In breast cancer, breast CSCs (BCSCs) were identified as CD24-CD44+ cells or cells with high intracellular aldehyde dehydrogenase activity. Elucidation of the role of insulin-like growth factor-1 in breast cancer stem cells (BCSCs) is crucial to the design of breast cancer therapies targeting BCSCs. [Breast Cancer Res] Abstract | Full Article c-MYC Regulated miR-23a~24-2~27a Cluster Promotes Mammary Carcinoma Cell Invasion and Hepatic Metastasis by Targeting Sprouty2 Investigators observed that the expression levels of microRNA (miR)-23a, miR-24-2 and miR-27a were significantly higher in breast cancer with lymph node metastasis, compared with that from patients without lymph node metastasis or normal tissue. Forced expression of the miR-23a~24-2~27a cluster promoted mammary carcinoma cell migration, invasion and hepatic metastasis, through targeting Sprouty2, and consequent activation of p44/42 MAPK. [J Biol Chem] Abstract | Full Article Fusion of CCL21 Non-Migratory Active Breast Epithelial and Breast Cancer Cells Give Rise to CCL21 Migratory Active Tumor Hybrid Cell Lines Scientists investigated M13HS hybrid cell lines, derived from spontaneous fusion events between M13SV1-EGFP-Neo breast epithelial cells exhibiting stem cell characteristics and HS578T-Hyg breast cancer cells, concerning CCL21/CCR7 signaling. [PLoS One] Full Article BMP4 Is a Novel Transcriptional Target and Mediator of Mammary Cell Migration Downstream of the Hippo Pathway Component TAZ Researchers provide convincing evidence that overexpression of TAZ in a mammary epithelial cell line, MCF10A, leads to enhanced cell migration – a fundamental characteristic of the metastatic progression of cancers. In addition, they identified the secreted growth factor BMP4 as mediating TAZ-induced cell migration. [Cell Signal] Abstract CLINICAL RESEARCH A Multigene Expression Assay to Predict Local Recurrence Risk for Ductal Carcinoma In Situ of the Breast The Oncotype DX breast cancer assay was performed for patients with ductal carcinoma in situ (DCIS) treated with surgical excision without radiation in the Eastern Cooperative Oncology Group E5194 study. The association of the prospectively defined DCIS Score (calculated from seven cancer-related genes and five reference genes) with the risk of developing an ipsilateral breast event was analyzed using Cox regression. [J Natl Cancer Inst] Full Article | Press Release The Efficacy of Lapatinib in Metastatic Breast Cancer with HER2 Non-Amplified Primary Tumors and EGFR Positive Circulating Tumor Cells: A Proof-Of-Concept Study The authors examined whether lapatinib which binds both HER2 and EGFR could induce depletion of the EGFR-positive pool of circulating tumor cells (CTCs), which may in turn lead to clinical benefits. Patients with metastatic breast cancer and HER2 non-amplified primary tumors with EGFR-positive CTCs were recruited and lapatinib 1500 mg daily was administered, in a standard two step phase II trial. [PLoS One] Full Article First-Line Treatment Patterns and Clinical Outcomes in Patients with HER2-Positive and Hormone Receptor-Positive Metastatic Breast Cancer from RegistHER The authors examined first-line treatment patterns and clinical outcomes in patients with HER2-positive, hormone receptor-positive metastatic breast cancer in a real-world setting. Progression-free survival and overall survival times were examined. [Oncologist] Abstract | Press Release |
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