LABORATORY RESEARCH A Common Docking Domain in Progesterone Receptor-B Links DUSP6 and CK2 Signaling to Proliferative Transcriptional Programs in Breast Cancer Cells Scientists describe an N-terminal common docking (CD) domain in progesterone receptor (PR)-B, a motif first described in mitogen-activated protein kinases. Binding studies revealed PR-B interacts with dual-specificity phosphatase 6 (DUSP6) via the CD domain. [Nucleic Acids Res] Full Article Comprehensive Analysis of miRNA Targets in Breast Cancer Cells Investigators systematically identified endogenous microRNA (miRNA) target genes by using AGO2 immunoprecipitation and microarray analyses in two breast cancer cell lines, MCF7 and MDA-MB-231, representing luminal and basal-like breast cancer, respectively. [J Biol Chem] Abstract | Full Article Nuclear T-STAR Protein Expression Correlates with HER2 Status, Hormone Receptor Negativity and Prolonged Recurrence Free Survival in Primary Breast Cancer and Decreased Cancer Cell Growth In Vitro The authors investigated the functional role of testis-signal transduction and activation of RNA (T-STAR) through survival analysis of patients with primary invasive breast cancer and experimental evaluation of the effect of T-STAR on breast cancer cell growth. [PLoS One] Full Article Epigenetic Modifications of Prostate-Derived Ets Transcription Factor in Breast Cancer Cells To date, no studies have been conducted to elucidate the epigenetic modifications of prostate-derived Ets factor (PDEF) in cancer progression. Using breast and prostate cancer cells, scientists investigated the effect of the methylation inhibitor 5′ azacytidine on the expression of PDEF in these cells. [Oncol Rep] Abstract Systemic Alteration of Cell Surface and Secreted Glycoprotein Expression in Malignant Breast Cancer Cell Lines Glycoproteins expressed by a group of cell lines originating from malignant tumors of the breast were compared to those expressed by a non-malignant set. [Glycobiology] Abstract Crosstalk between PKCα and Notch-4 in Endocrine-Resistant Breast Cancer Cells The authors tested whether PKCα overexpression affects Notch activity and whether Notch signaling contributes to endocrine resistance in PKCα-overexpressing breast cancer cells. [Oncogenesis] Full Article CLINICAL RESEARCH Tamoxifen and Risk of Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers Researchers sought to determine whether adjuvant tamoxifen treatment for breast cancer is associated with reduced contralateral breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. [J Clin Oncol] Abstract | Press Release CX3CL1 Expression Is Associated with Poor Outcome in Breast Cancer Patients CX3CL1 expression was examined in a large cohort of breast cancers by immunohistochemistry and its association with clinicopathological factors, biomarker expression, and impact on patients’ survival was assessed. [Breast Cancer Res Treat] Abstract Relationship between Genotypes Sult1a2 and Cyp2d6 and Tamoxifen Metabolism in Breast Cancer Patients Prior work has revealed a role of cytochrome and sulfotransferase enzymes in tamoxifen metabolism. In this descriptive study, correlations were examined between concentrations of tamoxifen metabolites and genotypes for CYP2D6, CYP3A4, CYP3A5, SULT1A1, SULT1A2 and SULT1E1 in 135 patients with estrogen receptor-positive breast cancer. [PLoS One] Abstract |