LABORATORY RESEARCH PPAR? and RXR Ligands Disrupt the Inflammatory Cross-Talk in the Hypoxic Breast Cancer Stem Cells Niche Researchers found that 6-OH-11-O-hydroxyphenanthrene potentiates the ability of pioglitazone to hamper the mammospheres-forming capability of human breast tumors and MCF7 cancer cells, reducing the expression of cancer stem cells regulatory genes. [J Cell Physiol] Abstract The Apoptotic Effect of D Rhamnose ß-Hederin, a Novel Oleanane-Type Triterpenoid Saponin on Breast Cancer Cells D Rhamnose ß-hederin showed strong inhibitory activity on the growth of various breast cancer cells and induced apoptosis in these cells. [PLoS One] Full Article Vasoinhibins, N-Terminal Mouse Prolactin Fragments, Participate in Mammary Gland Involution Incubation of mammary gland fragments and MCF7 with 16kDa mouse prolactin recombinant provided a proapoptotic effect in mammary epithelial cells. [J Mol Endocrinol] Abstract The Inflammatory Cytokine TNFalpha Cooperates with Ras in Elevating Metastasis and Turns WT-Ras to a Tumor-Promoting Entity in MCF-7 Cells TNFalpha cooperates with Ras in promoting the metastatic phenotype of MCF-7 breast tumor cells, and turns WT-Ras into a tumor-supporting entity. [BMC Cancer] Abstract | Full Article Mechanisms Underlying Differential Response to Estrogen-Induced Apoptosis in Long-Term Estrogen-Deprived Breast Cancer Cells Data suggests that MCF-7:2A cells employ stronger antioxidant defense mechanisms than do MCF-7:5C cells, and that oxidative stress is ultimately required for MCF-7:2A cells to die in response to estradiol treatment. [Int J Oncol] Abstract Bone-Derived Soluble Factors and Laminin-511 Cooperate to Promote Migration, Invasion and Survival of Bone-Metastatic Breast Tumor Cells Scientists used the bone-metastatic 4T1BM2 mammary carcinoma model to investigate the cooperative interactions between tumor LM-511 and bone-derived soluble factors in vitro. [Growth Factors] Abstract Silencing of ETS1 Reverses Adriamycin Resistance in MCF-7/ADR Cells via Downregulation of MDR1 Researchers investigated the effects of Erythroblastosis virus E26 oncogene homolog 1 (ETS1) on adriamycin resistance in MCF-7/ADR cells. ETS1 mRNA and protein was significantly overexpressed in MCF-7/ADR cells, compared to MCF-7 cells. [Cancer Cell Int] Abstract | Full Article Normal Mammary Development and Function in Mice with Ift88 Deleted in MMTV- and K14-Cre Expressing Cells Researchers developed mouse models with deletion of primary cilia (PC) in mammary luminal epithelial, basal epithelial, and stromal cells for evaluation of the function of PC in mammary development via MMTV-Cre, K14-Cre, and Prx1-Cre mediated deletion, respectively. [Cilia] Full Article CLINICAL RESEARCH Multicenter Phase II Study of Apatinib, a Novel VEGFR Inhibitor in Heavily Pretreated Patients with Metastatic Triple Negative Breast Cancer Investigators evaluated the optimum dose level for the efficacy and safety of apatinib monotherapy in heavily pretreated patients with metastatic triple negative breast cancer in China. [Int J Cancer] Abstract Temsirolimus and Pegylated Liposomal Doxorubicin (PLD) Combination Therapy in Breast, Endometrial, and Ovarian Cancer: Phase Ib Results and Prediction of Clinical Outcome with FDG-PET/CT Preclinical data suggest that the combination of PLD with a mammalian target of rapamycin inhibitor has an additive effect. The safety and recommended phase two dose of temsirolimus in combination with PLD were assessed. [Target Oncol] Abstract |