Mammary Cell News Volume 6.40 | Oct 16 2014

Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53 Null Mammary Carcinomas
Densely ionizing radiation has potentially greater carcinogenic effect compared to sparsely ionizing radiation that is prevalent on earth. Investigators used a radiation chimera in which mice were exposed to densely ionizing 350 MeV/amu Si-particles, gamma-radiation, or sham-irradiated and transplanted three days later with syngeneic Trp53 null mammary fragments. [Cancer Res] Abstract

Fra-1/AP-1 Induces EMT in Mammary Epithelial Cells by Modulating Zeb1/2 and TGFβ Expression
Ectopic expression of Fra-1 in fully polarized, non-tumorigenic, mouse mammary epithelial EpH4 cells induced a mesenchymal phenotype, characterized by a loss of epithelial and gain of mesenchymal markers. Proliferation, motility and invasiveness were also increased in the resulting EpFra1 cells, and the cells were tumorigenic and efficiently colonized the lung upon transplantation. [Cell Death Differ] Abstract

Direct Incorporation of the NKT-Cell Activator α-Galactosylceramide into a Recombinant Listeria monocytogenes Improves Breast Cancer Vaccine Efficacy
Researchers analyzed whether the natural killer T (NKT) cell-activating glycolipid α-galactosylceramide could overcome immune suppression and improve vaccination against metastatic breast cancer. [Br J Cancer] Abstract

Spontaneous Dormancy of Metastatic Breast Cancer Cells in an All Human Liver Microphysiologic System
The authors describe a human ex vivo hepatic microphysiologic system. Breast cancer cells intercalate into the hepatic niche without interfering with hepatocyte function. Examination of cancer cells demonstrated that a significant subset enter a quiescent state of dormancy as shown by lack of cell cycling. [Br J Cancer] Abstract

Curcumin Inhibits Breast Cancer Stem Cell Migration by Amplifying the E-Cadherin/Beta-Catenin Negative Feedback Loop
Curcumin, a plant ployphenol, has several anti-tumor effects and has been shown to target cancer stem cells (CSCs). Researchers evaluated the mechanisms underlying the aggravated migration potential of breast CSCs and the effects of curcumin in modulating the same. [Stem Cell Res Ther] Abstract | Full Article

Characterization of β2-Microglobulin Expression in Different Types of Breast Cancer
Researchers characterized β2-microglobulin (β2-M) expression in molecular subtypes of breast cancer, thereby investigating the mechanism of β2-M action in breast cancer. [BMC Cancer] Full Article

CLINICAL RESEARCH

Statin Use after Diagnosis of Breast Cancer and Survival: A Population-Based Cohort Study
Preclinical studies have shown that statins, particularly simvastatin, can prevent growth in breast cancer cell lines and animal models. Scientists investigated whether statins used after breast cancer diagnosis reduced the risk of breast cancer-specific, or all-cause, mortality in a large cohort of breast cancer patients. [Epidemiology] Abstract

IL6 Genotype, Tumor ER-Status, and Treatment Predicted Disease-Free Survival in a Prospective Breast Cancer Cohort
Researchers investigated the association between interleukin-6 (IL6) genotypes, estrogen receptor (ER)-status, and treatment on the risk of early events among breast cancer patients. [BMC Cancer] Full Article

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Pfizer Announces FDA Acceptance of Palbociclib New Drug Application with Priority Review
Pfizer Inc. announced the New Drug Application for palbociclib has been accepted for filing and granted Priority Review by the United States Food and Drug Administration (FDA). [Pfizer Inc.] Press Release

Regen BioPharma Inc. Files IND Application with FDA for dCellVax Breast Cancer Immune Therapy
Regen BioPharma Inc. announced the filing of an Investigational New Drug (IND) application to the United States Food and Drug Administration (FDA) to initiate a clinical trial assessing safety and therapeutic effects of dCellVax in patients with metastatic breast cancer. [Regen BioPharma Inc. (Marketwire L.P.)] Press Release

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Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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NEW Postdoctoral Fellow – Breast Cancer (University of Texas Health Science Center at San Antonio)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Postdoctoral Position – Breast Cancer Biology (UT Southwestern)

Postdoctoral Research Fellow – Cell Cycle Regulatory Pathways in Breast Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Breast Cancer Research (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellow – Stem Cells and Breast Cancer (Albert Einstein College of Medicine)

Postdoctoral Positions – Cell Death of Normal Tissue Stem Cells (Sloan-Kettering Institute)

Postdoctoral Fellow – Breast Cancer Translational Research (University of Houston – College of Pharmacy)

Scientist – Mammary Cell Research (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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