LABORATORY RESEARCH Reprogramming of the ERRα and ERα Target Gene Landscape Triggers Tamoxifen Resistance in Breast Cancer Investigators analyzed estrogen-related receptor-α (ERRα) and estrogen receptor-α (ERα) in recurrent tamoxifen-resistant breast tumors and conducted a genome-wide target gene profiling analysis of MCF-7 breast cancer cell populations that were sensitive or resistant to tamoxifen treatment. [Cancer Res] Abstract The Breast Cancer Susceptibility FGFR2 Provides an Alternate Mode of HER2 Activation Scientists show that mouse mammary tumor virus-neu mice develop breast carcinomas with fibroblast growth factor receptor 2 (FGFR2) immunoreactivity that parallels HER2 expression. Functionally, FGFR2 facilitates HER2-mediated cell proliferation, acinar growth in three-dimensional morphogenesis assays and promotes tumor progression in mouse xenografts. [Oncogene] Abstract Beclin 1 Regulates Growth Factor Receptor Signaling in Breast Cancer Investigators describe an alternative mechanism of action for beclin 1 in breast cancer involving its control of growth factor receptor signaling. Suppression of BECN1 sustains growth factor-stimulated AKT and ERK activation resulting in increased breast carcinoma cell invasion. [Oncogene] Abstract Mechanisms of Gefitinib-Mediated Reversal of Tamoxifen Resistance in MCF-7 Breast Cancer Cells by Inducing ERα Re-Expression By investigating the phenomenon that gefitinib can re-sensitize tamoxifen (TAM)-resistant MCF-7 breast cancer cells to TAM, researchers verified that gefitinib could reverse the acquired drug resistance in endocrine therapy and further explored the underlying mechanism. [Sci Rep] Full Article ZnT2 Is a Critical Mediator of Lysosomal-Mediated Cell Death during Early Mammary Gland Involution The Zinc (Zn) transporter ZnT2 imports Zn into vesicles and mitochondria and ZnT2-overexpression activates cell death in mammary epithelial cells. Researchers tested the hypothesis that ZnT2-mediated Zn transport is critical for mammary gland involution in mice. [Sci Rep] Full Article Elimination of ALDH+ Breast Tumor Initiating Cells by Docosahexaenoic Acid and/or Gamma Tocotrienol through SHP-1 Inhibition of STAT3 Signaling Scientists investigated the ability of docosahexaenoic acid alone and in combination with gamma-tocotrienol to eliminate aldehyde dehydrogenase positive (ALDH+) cells and to inhibit mammosphere formation, biomarker and functional assay for tumor initiating cells. [Mol Carcinog] Abstract mTOR/MYC Axis Regulates O-GlcNAc Transferase (OGT) Expression and O-GlcNAcylation in Breast Cancer The authors show that the PI3K/mTOR/MYC signaling pathway is required for elevation of OGT and O-GlcNAcylation in breast cancer cells. Treatment with PI3K and mTOR inhibitors reduced OGT protein expression and decreased levels of overall O-GlcNAcylation. [Mol Cancer Res] Abstract miR-200b Expression in Breast Cancer: A Prognostic Marker and Act on Cell Proliferation and Apoptosis by Targeting Sp1 Researchers investigated the roles and mechanisms of microRNA (miR)-200b in human breast cancer (BC). They found that miR-200b was significantly down-regulated in both BC tissues and cell lines. [J Cell Mol Med] Full Article TOX3 Is Expressed in Mammary ER+ Epithelial Cells and Regulates ER Target Genes in Luminal Breast Cancer In vitro studies were performed on MCF7, BT474 and MDA-MB-231 cell lines to study the effects of TOX3 modulation on gene expression in the context of breast cancer cells. Scientists found TOX3 expression in estrogen receptor-positive mammary epithelial cells, including progenitor cells. [BMC Cancer] Abstract | Full Article CLINICAL RESEARCH A Phase II Study of a Dose-Density Regimen with Fluorouracil, Epirubicin, and Cyclophosphamide on Days One and Four Every 14 Days with Filgrastim Support Followed by Weekly Paclitaxel in Women with Primary Breast Cancer Investigators evaluated administration of an epirubicin-based regimen with paclitaxel in a sequential, dose-dense schedule as adjuvant treatment for patients with high-risk primary breast cancer. [Oncologist] Abstract | Full Article A Phase II Trial of Biweekly Vinorelbine and Oxaliplatin in Second- or Third-Line Metastatic Triple-Negative Breast Cancer Researchers evaluated the efficacy and toxicity of biweekly combination of vinorelbine and oxaliplatin in second- or third-line setting for metastatic triple-negative breast cancer. [Cancer Biol Ther] Abstract |