LABORATORY RESEARCH Cartilage Oligomeric Matrix Protein Contributes to the Development and Metastasis of Breast Cancer In vitro experiments confirmed that cartilage oligomeric matrix protein (COMP)-expressing cells had a more invasive phenotype, which could in part be attributed to an upregulation of matrix metalloprotease-9. Furthermore, microarray analyses of gene expression in tumors formed in vivo showed that COMP expression induced higher expression of genes protecting against endoplasmic reticulum stress. [Oncogene] Abstract | Press Release miR-155 Downregulates ErbB2 and Suppresses ErbB2-Induced Malignant Transformation of Breast Epithelial Cells Scientists found that ErbB2 expression was inversely correlated with the level of miR-155, a well-documented oncogenic miRNA, in ErbB2-positive breast tumors. They further determined that miR-155 potently suppresses ErbB2 in breast cancer cells. [Oncogene] Abstract Chemotherapy-Induced Uridine Diphosphate Release Promotes Breast Cancer Metastasis through P2Y6 Activation The authors demonstrated that UDP/P2Y6 signaling facilitates breast cancer metastasis both in vitro and in vivo. They found that P2Y6 is not only aberrantly expressed and mutated in most tumor types, but also highly correlated with poor prognosis in breast cancer patients. [Oncotarget] Full Article GPER Signaling in Both Cancer-Associated Fibroblasts and Breast Cancer Cells Mediates a Feedforward IL1β/IL1R1 Response Investigators demonstrated that signaling mediated by the G protein estrogen receptor (GPER) triggers IL1β and IL1R1 expression in cancer-associated fibroblasts and breast cancer cells, respectively. [Sci Rep] Full Article Bioorthogonal Two-Component Drug Delivery in HER2(+) Breast Cancer Mouse Models Researchers developed a two-component, two-step, pre-targeting drug delivery system integrated with image guidance to circumvent these issues. In this strategy, HER2 receptors were pre-labeled with a functionalized trastuzumab antibody followed by the delivery of drug-loaded nanocarriers. [Sci Rep] Full Article A Novel EGR-1 Dependent Mechanism for YB-1 Modulation of Paclitaxel Response in a Triple Negative Breast Cancer Cell Line Researchers aimed to determine mechanisms by which Y-box binding protein 1 (YB-1) confers paclitaxel (PTX) resistance. They generated isogenic triple negative breast cancer cell lines that differed by YB-1 levels and treated these with PTX. [Int J Cancer] Abstract Parthenolide and DMAPT Exert Cytotoxic Effects on Breast Cancer Stem-Like Cells by Inducing Oxidative Stress, Mitochondrial Dysfunction and Necrosis Researchers report the production of mammospheres from three lines of triple-negative breast cancers cells and demonstrated that both parthenolide and its soluble analog dimethylaminoparthenolide (DMAPT) suppressed this production and induced cytotoxic effects in breast cancer stem-like cells, derived from dissociation of mammospheres. [Cell Death Dis] Full Article HDAC8 Inhibition Blocks SMC3 Deacetylation and Delays Cell Cycle Progression without Affecting Cohesin-Dependent Transcription in MCF7 Cancer Cells Scientists blocked deacetylation of ac-SMC3 using an HDAC8-specific inhibitor PCI-34051 in MCF7 breast cancer cells, and examined the effects on transcription of cohesin-dependent genes that respond to estrogen. [J Biol Chem] Abstract | Full Article CLINICAL RESEARCH Absolute Benefit of Adjuvant Endocrine Therapies for Premenopausal Women with Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Early Breast Cancer: TEXT and SOFT Trials The authors examined absolute treatment effect across a continuum of recurrence risk to individualize endocrine therapy decision making for premenopausal women with human epidermal growth factor receptor 2-negative disease. [J Clin Oncol] Abstract |