Mammary Cell News 8.34 September 1, 2016 | |
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TOP STORYScientists report significant enrichment of somatic mutations within the set of regulatory elements regulating estrogen receptor-α (ESR1) in 7% of ESR1-positive breast cancers. These mutations regulate ESR1 expression by modulating transcription factor binding to the DNA. [Nat Genet] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHRB1 Deficiency in Triple-Negative Breast Cancer Induces Mitochondrial Protein Translation Scientists determined that combined inactivation of murine retinoblastoma tumor-suppressor gene (RB1) and p53 in diverse mammary epithelial cells induced claudin-low-like triple-negative breast cancer with Met, Birc2/3-Mmp13-Yap1, and Pvt1-Myc amplifications. [J Clin Invest] Full Article Scientists used a mouse model of pre-diabetes was used to investigate the mechanisms through which endogenous hyperinsulinemia promotes mammary tumor metastases. [Oncogene] Abstract The authors evaluated the effect of several decalcification procedures on receptor status and DNA/RNA quality. In 23 prospectively collected breast tumors, they compared ERα, PR and HER2 status by immunohistochemistry in tissue routinely processed for diagnostic purposes and in parallel tissue decalcified in Christensen’s buffer with and without microwave, EDTA and Formical-4. [Mod Pathol] Abstract Investigators developed a therapeutic formulation using cholesterol-modified miR-143 agomir encapsulated in a neutral lipid-based delivery agent that blocked tumor growth and glucose metabolism in triple-negative breast cancer tumor-bearing mice when administered systemically. [Mol Ther Nucleic Acids] Full Article CEACAM1 Controls the EMT Switch in Murine Mammary Carcinoma In Vitro and In Vivo Investigators analyzed the molecular basis for carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)-controlled inhibition of epithelial-mesenchymal transition (EMT) in a mouse model for mammary adenocarcinoma (WAP-T mice). They demonstrated that silencing of CEACAM1 in WAP-T tumor-derived G-2 cells induces epithelial-mesenchymal plasticity, as evidenced by typical changes of gene expression, morphology and increased invasion. [Oncotarget] Full Article Researchers bioinformatically predicted a role for Stat3 in Myc induced mammary tumors and tested it using mouse models. During normal mammary function, loss of Stat3 in Myc transgenic dams resulted in lethality of pups due to lactation deficiencies. [Oncotarget] Full Article Investigators present a relatively high throughput approach to spatially assess epithelial cell proliferation in whole mouse mammary gland using histochemical detection of 5-ethynyl-2`-deoxyuridine (EdU) in conjunction with a standard curve-based data deconvolution technique to semi-quantitatively measure proliferation via widefield epifluorescent microscopy. [Endocrinology] Abstract Researchers revealed the role of LSD1 in breast cancer development. In addition, it has been reported that phosphorylation of the Serine 112 residue of LSD1 by PKCα is crucial for its function in gene regulation. They also explored whether this phosphorylation affects LSD1’s role in breast cancer development. [Breast Cancer Res Treat] Abstract As the known number of AHR-mediated processes grows, so too does the importance of determining what endogenous AHR ligands are produced, how their production is regulated, and what biological consequences ensue. The authors’ studies were designed primarily to determine if ER–/PR–/Her2– breast cancer cells have the potential to produce endogenous AHR ligands and, if so, how production of these ligands is controlled. [Mol Pharmacol] Abstract | Full Article CLINICAL RESEARCHPEGGY, a randomized, placebo-controlled Phase II trial, examined whether pictilisib augments the anti-tumor activity of paclitaxel in patients with hormone receptor-positive, HER2-negative locally recurrent or metastatic breast cancer. The authors report results from the protocol-specified interim analysis. [Ann Oncol] Abstract Researchers looked at three immunohistochemical progesterone receptor assays, in addition to original ligand-binding assay results, in a single retrospective, tamoxifen-treated breast cancer cohort to investigate inter- and intra-observer agreement, concordance, prognostic ability and measures of test performance. [Mod Pathol] Abstract | |
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REVIEWSThe Metabolic Fate of Acetate in Cancer The reviewers discuss how acetate functions as a nutritional source for tumors and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention. [Nat Rev Cancer] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSGradalis® Inc. announced that the first patient has been dosed in a pilot study combining Vigil® Engineered Autologous Tumor Cells with durvalumab in advanced breast cancer. [Gradalis® Inc.] Press Release Biocept, Inc. announced the grant of a Chinese patent entitled, Methods and Reagents for Signal Amplification. The issued patent corresponds to the current Chinese Patent Application No. 201180056340.0 and covers the use of a novel stain in the detection of rare cells such as circulating tumor cells from blood and other biological fluids. [Biocept, Inc.] Press Release | |
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POLICY NEWSFDA Reaches Agreement with Generics Industry on New GDUFA Commitments The Food and Drug Administration and the generic drug manufacturing industry — including representatives of generic pharmaceutical manufacturers, active pharmaceutical ingredient manufacturers and contract manufacturing organizations — have reached agreement on a package of program enhancements and resource commitments to reauthorize the Generic Drug User Fee Amendments of 2012 (GDUFA), which are set to expire next year. [Drug Store News] Editorial NSF Proposes Changes in Use of Costly Rotators for Senior Positions The National Science Foundation (NSF) believes that having academics spend anywhere from two to four years at the agency before returning to campus helps it identify and fund cutting-edge research. Last year 176 scientists, about 28% of NSF’s scientific workforce, were on such temporary assignments. But NSF’s heavy use of these so-called rotators is unique among government research agencies. And some members of Congress are worried that the government is paying too steep a price for that management strategy. [ScienceInsider] Editorial
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EVENTSNEW 15th St. Gallen International Breast Cancer Conference 2017 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Rho GTPase Signaling in the Process of Breast Cancer (University of Leeds) Faculty Pathologist – Breast Pathology (University of California Los Angeles) Postdoctoral Researcher – Breast Cancer (Purdue University) Robert Stowell Chair – Experimental Pathology (University of California, Davis) Postdoctoral Position – Metastatic Reactivaction of Cancer (MD Anderson Cancer Center) Scientific Director – Oncology (Merck) Postdoctoral Fellow – Various Projects (National University of Singapore) Postdoctoral Fellow – Breast Cancer Monitoring through Digital Imaging (University Rovira i Virgili) Manager – Medical and Breast Imaging (Fred Hutchinson Cancer Research Center) Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mammary Cell News Volume 8.34 | Sep 1 2016