Mammary Cell News 9.28 July 20, 2017 | |
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TOP STORYCancer Cells Force Normal Cells to Mimic Viruses to Help Tumors Spread, Resist Treatment In a study that could explain why some breast cancers are more aggressive than others, researchers said they now understand how cancer cells force normal cells to act like viruses – allowing tumors to grow, resist treatment, and spread. [Press release from Penn Medicine discussing online prepublication in Cell] Press Release | Abstract | Graphical Abstract | Video Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHScientists selected photopolymerized polyacrylamide gels with varying stiffness as model substrates, and studied the impact of matrix stiffness on cell morphology, nanoparticle uptake efficiency in two representative breast cancer cell lines with varying invasiveness. [ACS Appl Mater Interfaces] Abstract Investigators reported that BAG family molecular chaperone regulator 3 (BAG3) was induced under specific floating culture conditions that enrich breast cancer stem cell-like cells in spheres. [Cell Death Dis] Full Article With the aim of making specific targeting of silver nanoparticles as a drug for tumor cells and developing new anticancer agents, a novel nano-composite was developed. Albumin coated silver nanoparticles were synthesized, and their anti-cancerous effects were evaluated against MDA-MB 231, a human breast cancer cell line. [Sci Rep] Full Article MEN1/Menin Regulates Milk Protein Synthesis through mTOR Signaling in Mammary Epithelial Cells The MEN1 gene, which encodes the protein Menin, was investigated for its regulatory role in milk protein synthesis in mammary glands. [Sci Rep] Full Article Researchers investigated the role of MICAL2 in breast cancer cell migration as well as its underlying mechanisms. [Acta Physiol (Oxf)] Abstract Zinc metallized phthalocyanine, a potent photosensitizer, was conjugated to gold dendrimer encapsulated nanoparticles in order to improve the efficacy of photodynamic therapy using MCF-7 breast cancer cells and WS1 fibroblast cells as a control. [J Biophotonics] Abstract Scientists aimed to study the association of the hostile environment developed in 3D with the breast cancer stem cells population and the HER2 modulation. [J Cell Biochem] Abstract BMP-2 Induces EMT and Breast Bancer Stemness Through Rb and CD44 Investigators conducted a comprehensive molecular study using breast cancer cell lines and clinical samples. Their results showed that downregulation of Rb by BMP-2 was associated with ubiquitin-mediated degradation activated by phosphorylation of Rb via the PI3K/AKT signal pathway. [Cell Death Discov] Full Article CLINICAL RESEARCHResearchers aimed to assess the efficacy of neoadjuvant chemotherapy in a cohort of 213 triple-negative breast cancer patients treated in real-world practice at eight Italian cancer centers. [J Cell Physiol] Abstract Genomic DNA of women from 12 major cancer centers with a first diagnosis of invasive breast cancer who identified themselves and all four grandparents as Ashkenazi Jewish and participated in the New York Breast Cancer Study from 1996 to 2000 was sequenced for known and candidate breast cancer genes. [JAMA Oncol] Abstract | Press Release Scientists determined whether the BRCA1 and BRCA2 germline mutation status affects therapy response in patients with triple-negative breast cancer. [JAMA Oncol] Abstract | |
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REVIEWSBreast Cancer Stem Cells as Last Soldiers Eluding Therapeutic Burn: A Hard Nut to Crack Investigators summarize major scientific breakthroughs in understanding the contribution of breast cancer stem cells towards tumor’s capability to endure destruction inflicted by molecular as well as genotoxic drugs. [Int J Cancer] Abstract The authors focus on the clinical management of potential toxicities and drug interactions seen with the use of CDK4/6 inhibitors in breast cancer, with a focus on palbociclib and ribociclib, and summarizes practical management strategies for an oncologist. [Oncologist] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSFDA Approves New Treatment to Reduce the Risk of Breast Cancer Returning The U.S. Food and Drug Administration approved Nerlynx (neratinib) for the extended adjuvant treatment of early-stage, HER2-positive breast cancer. [U.S. Food and Drug Administration] Press Release ESMO Awards Recognise Four Outstanding Oncologists The European Society for Medical Oncology (ESMO) announced the recipients of its four distinguished annual awards, to be presented at the ESMO 2017 Congress. [European Society for Medical Oncology] Press Release | |
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POLICY NEWSSome Scientists Hate NIH’s New Definition of a Clinical Trial. Here’s Why Scientists in behavioral research fields — from cognitive psychology to vision science — were dismayed to learn that the U.S. National Institutes of Health (NIH) in Bethesda, Maryland, could soon deem their studies to be clinical trials. [ScienceInsider] Editorial Salk Institute under Fire for ‘Smear’ on Women Suing It for Discrimination Alleging decades of gender discrimination, two senior female scientists sued the Salk Institute for Biological Studies, sparking a public relations debacle that has engulfed the venerable institution and could threaten its appeal to donors and new researchers. Leaders of the San Diego, California, research center have strenuously denied the allegations made by biologists Vicki Lundblad and Katherine Jones, and publicly questioned their productivity and the quality of their scientific work. [ScienceInsider] Editorial
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EVENTSNEW 25th Biennial Congress of the European Association for Cancer Research (EACR) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW RCSI Funded PhD – Cancer Systems Biology/Bioinformatics (Royal College of Surgeons in Ireland) Postdoctoral Fellow – Cancer Research (University of Texas Health Science Center at San Antonio) Postdoctoral Positions – Molecular Cancer Research (University of Copenhagen and Rigshospitalet) Postdoctoral Fellow – Cancer Genomics (University of Texas Health Science Center at Houston) Canada Research Chair – Tumor Biology (University of Manitoba) Postdoctoral Research Position – Experimental Oncology (KTH Royal Institute of Technology) Postdoctoral Positions – Breast Cancer (Northwestern University – Feinberg School of Medicine) Postdoctoral Training Fellow – Cancer Metabolism (The Francis Crick Institute) Research Assistant – Breast Cancer (University of British Columbia) Clinician Investigator – Breast Cancer Research (Mayo Clinic) Postdoctoral Research Associate – Breast Cancer (University of Nebraska Medical Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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