Mesenchymal Cell News 10.01 January 9, 2018 | |
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TOP STORYTherapy-Educated Mesenchymal Stem Cells Enrich for Tumor Initiating Cells Investigators showed that chemotherapy-educated mesenchymal stem cells promote therapy resistance via crosstalk with tumor-initiating cells, a resistant tumor cell subset that initiates tumorigenesis and metastasis. [Cancer Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROResearchers showed that cytochalasin D, which may function by redistributing the intracellular location of β-actin, is a potent osteogenic stimulant as reflected by significant increases in alkaline phosphatase activity, extracellular matrix mineralization, and osteoblast-related gene expression. [Stem Cells Transl Med] Full Article Scientists constructed long-term and stable mouse MSCs lines overexpressing and suppressing CXC receptor seven (CXCR7) modifications with lentiviral vectors. Overexpressing CXCR7 improved the proliferation and migration of mouse MSCs, which may be attributable to the chemokine ligand 12 (CXCL12) secreted by MSCs, leading to a positive feedback loop for CXCL12/CXCR7 axis. [Sci Rep] Full Article Investigators established transwell co-cultures of rat hippocampal neurons and MSCs. They showed that MSCs and MSC-derived extracellular vesicles protect neurons against amyloid-beta peptide-induced oxidative stress and synapse damage, revealed by loss of pre- and post-synaptic markers. [J Biol Chem] Abstract | Full Article The authors report that licarin A (LA) stimulates the development of brown-like and beige-like adipocytes from C3H10T1/2 mesenchymal stem cells with phenotypic shifts to formation of smaller lipid droplets. LA also markedly induced the expression of proteins characteristic of brown-like adipocytes in C3H10T1/2 mesenchymal stem cells. [Toxicol Appl Pharmacol] Abstract | Graphical Abstract Scientists investigated the effect of continuous-wave low-intensity ultrasound at 5.0-MHz and 14.0-kPa on the proliferative capacity, colony-formation efficiency, genetic stability and differentiation potential of human MSCs. [Biotechnol J] Abstract Researchers investigated the effects of metformin on the proliferation and differentiation of dental pulp cells. Levels of phosphorylated and unphosphorylated adenosine 5′-monophosphate-activated protein kinase (AMPK) were quantified by Western blot analysis in response to metformin and the AMPK signaling inhibitor Compound C. [J Endod] Abstract IN VIVOInvestigators assessed the impact of platelet-rich plasma scaffolds (PRPS) as support of MSCs in a delayed phase after severe traumatic brain injury in rats. They showed that a greater functional improvement was obtained after the administration of MSCs in PRPS compared with the other experimental groups. [Cytotherapy] Abstract Scientists aimed to verify the cytoprotective effect of ginsenoside Rg1 in vivo, and to elucidate the mechanism of Rg1 in the ischemic microenvironment. [Eur J Pharmacol] Abstract | Graphical Abstract The authors assessed the possible mechanism of exosomes isolated from conditioned media of MSC cultures (MSCexos) action on spinal cord injury (SCI) by investigating the tissue distribution and cellular targeting of DiR fluorescent labeled MSCexos at 3 hours and 24 hours after IV infusion in rats with SCI. [PLoS One] Full Article | |
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REVIEWSThe Metabolic Microenvironment Steers Bone Tissue Regeneration The authors provide a schematic overview on metabolic links that have a high potential to drive tissue regeneration. As bone is, aside from liver, the only tissue that can regenerate without excessive scar tissue formation, they will use bone healing as an exemplarily model system. [Trends Endocrinol Metab] Abstract Exosome and Mesenchymal Stem Cell Cross-Talk in the Tumor Microenvironment Although MSCs have a potential to exert anti-tumor activities, they largely provide service to the tumor using the multidirectional communication system established by exosomes in the tumor microenvironment (TME). Future therapeutic options consider disruption of this complex vicious cycle by either molecular or gene-regulated silencing of pro-tumor effects mediated by MSCs in the TME. [Semin Immunol] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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SCIENCE NEWSBell Biosystems, Inc. Announces Pre-Clinical Results of Major In Vivo Safety Study Milestone “Bell Biosystems, Inc. presented the results of their latest pre-clinical safety study. [Press release from Bell Biosystems, Inc. (PR Newswire Association LLC.) discussing research presented at the 2018 J.P. Morgan Healthcare Conference, San Francisco] Press Release | |
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INDUSTRY NEWSNew advances in regenerative medicine could improve the odds for a healthier life for people with metabolic syndrome. The National Institutes of Health’s National Institute on Aging recognized this, and recently awarded a prestigious research grant to Longeveron, a regenerative medicine therapy company based in Miami, Florida. [Longeveron] Press Release BioCardia®, Inc. reported filing a second Investigational Device Exemption with the FDA for the CardiAMP Chronic Myocardial Ischemia Trial to treat patients with refractory angina. [BioCardia®, Inc] Press Release | |
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POLICY NEWSKoch-Backed Groups Urge Congress to Pass Right-to-Try Legislation Several deep-pocketed political advocacy groups founded by Charles and David Koch are ramping up their advocacy before Congress on a niche issue: access to experimental drugs. [STAT News] Editorial Germany vs Elsevier: Universities Win Temporary Journal Access after Refusing to Pay Fees The Dutch publishing giant Elsevier has granted uninterrupted access to its paywalled journals for researchers at around 200 German universities and research institutes that had refused to renew their individual subscriptions at the end of 2017. [Nature News] Editorial
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EVENTSNEW The Australasian Society for Biomaterials and Tissue Engineering (ASBTE) 2018 Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Studentship – Regenerative Sciences (Hannover Biomedical Research School) NEW Assistant or Associate Professor – Orthopedics & Sports Medicine (University of Washington) Postdoctoral Fellow – Bone and Stem Cells Biology (Stanford University) Associate/Full Professor – Regenerative Medicine (University of Florida) Postdoctoral Position – Stem Cell Differentiation (University of California, Berkeley) Chair – Department of Cell and Regenerative Biology (University of Wisconsin) Postdoctoral Scholar Position – Cancer & Stem Cell Epigenomics (University of California, Davis) Postdoctoral Fellows – Stem Cell Biology and Regenerative Medicine (Stanford University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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