Mesenchymal Cell News Volume 10.03 | Jan 23 2018

TOP STORY

Mechanically-Sensitive miRNAs Bias Human Mesenchymal Stem Cell Fate via mTOR Signaling

Researchers identified differential miRNA expression in response to varying hydrogel stiffness and RhoA activity. They showed that modulation of miR-100-5p and miR-143-3p can be used to bias MSC fate and provide mechanistic insight by demonstrating convergence on mTOR signaling. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Human Bone Perivascular Niche-on-a-Chip for Studying Metastatic Colonization

Scientists showed that human bone marrow-derived mesenchymal stem cells, which have undergone phenotypical transition toward perivascular cell lineages, support the formation of capillary-like structures lining the vascular lumen. [Proc Natl Acad Sci USA] Full Article

Human Colorectal Cancer-Derived Mesenchymal Stem Cells Promote Colorectal Cancer Progression through IL-6/JAK2/STAT3 Signaling

Investigators found that colorectal cancer-derived MSCs (CC-MSCs) increased the migration and invasion of colorectal cancer cells and promoted the tumorigenesis of colorectal cancer through epithelial-to-mesenchymal transition in vitro. They also found that CC-MSCs enhanced the growth and metastasis of colorectal cancer in vivo. [Cell Death Dis] Full Article

Guanylate Binding Protein 1 Inhibits Osteogenic Differentiation of Human Mesenchymal Stromal Cells Derived from Bone Marrow

The authors found that mRNA expression of GBP1 was highest among all the guanylate binding protein (GBPs), and it was dramatically downregulated during osteogenic differentiation of human MSCs derived from bone marrow (hBM-MSCs). While siRNA-mediated knockdown of GBP1 promoted osteogenesis, overexpression of GBP1 suppressed osteogenesis of hBM-MSCs. [Sci Rep] Full Article

In Vitro Analysis of Quantum Molecular Resonance Effects on Human Mesenchymal Stromal Cells

Researchers evaluated the effects of Quantum Molecular Resonance (QMR) stimulation on bone marrow derived MSC. After one and two weeks of QMR treatment morphology, phenotype and multilineage differentiation were maintained and no alteration of cellular viability and proliferation were observed between treated MSC samples and controls. [PLoS One] Full Article

IN VIVO

Mesenchymal Stromal Cell Infusion Modulates Systemic Immunological Responses in Stable COPD Patients: A Phase I Pilot Study

Identifying the fate of intravenously-infused MSC and the potential implications of their biodistribution, as well as short-term MSC-induced systemic changes that were not explored in previous trials, will better delineate the utility of MSC treatment for chronic obstructive pulmonary disease (COPD). [Eur Respir J] Abstract

The Therapeutic Potential of Human Adipose-Derived Mesenchymal Stem Cells Producing CXCL10 in a Mouse Melanoma Lung Metastasis Model

Scientists assessed therapeutic potential of human adipose derived mesenchymal stem cells genetically-modified to express interferon γ-induced protein 10 kDa for the treatment of lung metastasis in an immunocompetent mouse model of metastatic melanoma. [Cancer Lett] Abstract

Cornea Derived MSCs Therapeutically Modulate Macrophage Immunophenotype and Angiogenic Function

The authors hypothesized that therapeutic use of cornea derived mesenchymal stromal cells (cMSCs) may alter the function of macrophages. In vivo, application of cMSCs to murine corneas after injury lead to reduced macrophage infiltration and higher expression of CD206 in macrophages. [Stem Cells] Abstract

Autophagy Promotes MSC-Mediated Vascularization in Cutaneous Wound Healing via Regulation of VEGF Secretion

Researchers proved that autophagy determines the therapeutic effect of MSCs in cutaneous wound healing through promoting endothelial cells angiogenesis and demonstrated that the paracrine of vascular endothelial growth factor (VEGF) in MSCs was required in wound site. [Cell Death Dis] Full Article

Bone Remodeling In Vitro: Where Are We Headed? A Review on the Current Understanding of Mimicking Physiological Bone Remodeling and Inflammation In Vitro and the Future Strategies for Testing Biomaterials In Vitro

The authors highlight the current understanding of the physiological bone remodeling and the bone healing process followed by strategies to incorporate both the physiological and pathophysiological events into an in vitro environment. [Bone] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Enrollment Completed in Randomized Clinical Trial of Habeo^™ Cell Therapy for Scleroderma and Impaired Hand Function

Cytori Therapeutics, Inc. announced completion of patient enrollment in SCLERADEC II, a randomized, double-blind, placebo-controlled, parallel group, multi-center clinical trial intended to study the safety and efficacy of Habeo^™ Cell Therapy in up to 40 subjects with impaired hand function due to scleroderma. [Cytori Therapeutics, Inc.] Press Release

Encouraging Early Safety and Efficacy Data in Cynata’s Phase I Trial of CYP-001 in GvHD; DSMB Recommendation to Initiate Enrollment of Second Patient Cohort

Cynata Therapeutics Limited announced that the independent Data Safety Monitoring Board (DSMB) has recommended that Cynata’s clinical trial of its lead Cymerus^™ MSC product CYP-001 should progress to the next stage as planned. [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] Press Release

U.S. Scientists Breathe a Sigh of Relief as Government Shutdown to End

It’s over—at least for the moment. The U.S. Senate voted 81–18 to advance legislation funding government activities, essentially ending a partial government shutdown that had moved into its third day. The House of Representatives is expected to follow suit, sending the bill to President Donald Trump for his signature. [ScienceInsider] Editorial

German Scientists Hope for Windfall from Incoming Government

Research budget could rise to 3.5% of gross domestic product if agreement struck during coalition talks holds. [Nature News] Editorial

Nobel Laureate Suggests He Could Fall on Sword over Colleague’s Bogus Paper

Shinya Yamanaka, who won a share of the 2012 Noble Prize in Physiology or Medicine for the discovery of induced pluripotent stem (iPS) cells, has suggested he could resign as director of Kyoto University’s Center for iPS Cell Research and Application in Japan over a fraudulent paper published by center researchers. [ScienceInsider] Editorial

NEW Annual Meeting of the Israel Stem Cell Society 2018
May 31, 2018
Tel Aviv, Israel

Visit our events page to see a complete list of events in the community.

NEW PhD Students – Biomarkers for Chronic Disease (University of Hull)

Program Director – Translational Bone Research (Hospital for Special Surgery and Weill Cornell Medicine)

PhD Studentship – Regenerative Sciences (Hannover Biomedical Research School)

Tenure Track Assistant Professor – Cell Biology and Anatomy (University of South Carolina School of Medicine)

Assistant or Associate Professor – Orthopedics & Sports Medicine (University of Washington)

Postdoctoral Fellow – Bone and Stem Cells Biology (Stanford University)

Associate/Full Professor – Regenerative Medicine (University of Florida)

Postdoctoral Associate Positions – Translational Musculoskeletal Research (Penn State College of Medicine)

Postdoctoral Position – Stem Cell Differentiation (University of California, Berkeley)

Chair – Department of Cell and Regenerative Biology (University of Wisconsin)

Postdoctoral Scholar Position – Cancer & Stem Cell Epigenomics (University of California, Davis)

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