Mesenchymal Cell News Volume 10.04 | Jan 30 2018

TOP STORY

A Quiescent Cell Population Replenishes Mesenchymal Stem Cells to Drive Accelerated Growth in Mouse Incisors

Using the archetypal MSC in vitro surface marker, CD90/Thy1, investigators showed that 30% of the MSCs in the continuously growing mouse incisor expressed CD90/Thy1 and these cells gave rise to 30% of the differentiated cell progeny during postnatal development. [Nat Commun] Full Article | Press Release

(Ranked by impact factor of the journal)

IN VITRO

Activated CD8⁺ T Cell Extracellular Vesicles Prevent Tumor Progression by Targeting of Lesional Mesenchymal Cells

Researchers showed that activated CD8⁺ T cell-derived extracellular vesicles (EVs) interrupt fibroblastic stroma-mediated tumor progression. Activated CD8⁺ T cells from healthy mice transiently released cytotoxic EVs causing marked attenuation of tumor invasion and metastasis by apoptotic depletion of mesenchymal tumor stromal cells. [Nat Commun] Full Article

Reduced Cdc42 Activity Compromises Hematopoiesis-Supportive Function of Fanconi Anemia Mesenchymal Stromal Cells

Scientists found that MSCs deficient for Fanca or Fancc gene are defective in proliferation and prone to undergo senescence in vitro. [Stem Cells] Abstract

Ubiquitin C Decrement Plays a Pivotal Role in Replicative Senescence of Bone Marrow Mesenchymal Stromal Cells

Human bone marrow-MSCs undergo cellular senescence during in vitro culture. The authors defined this replicative senescence as impaired proliferation, deterioration in representative cell characteristics, accumulated DNA damage, and decreased telomere length and telomerase activity with or without genomic abnormalities. [Cell Death Dis] Full Article

Efficient Scalable Production of Therapeutic Microvesicles Derived from Human Mesenchymal Stem Cells

Investigators successfully amplified microvesicle secretion from MSCs compared to the conventional culture method using a simple and efficient 3D-bioprocessing method. [Sci Rep] Full Article

Effects of Bone Marrow Mesenchymal Stem Cells Transfected with Ang-1 Gene on Hyperoxia-Induced Optic Nerve Injury in Neonatal Mice

Researchers investigated the role of bone marrow MSCs transfected with angiopoietin-1 (Ang-1) in optic nerve injury induced by hyperoxia in a neonatal mice model. [J Cell Physiol] Abstract

Ikkβ Is a β-Catenin Kinase that Regulates Mesenchymal Stem Cell Differentiation

Investigators showed that IκB kinase β (IKKβ) can reciprocally regulate adipocyte and osteoblast differentiation of murine and human MSCs through an NF-κB–independent mechanism. [JCI Insight] Full Article

IN VIVO

Employing Mesenchymal Stem Cells to Support Tumor-Targeted Delivery of Extracellular Vesicle (EV)-Encapsulated MicroRNA-379

The authors characterized a potential tumor suppressor microRNA, miR-379, and engineered MSCs to secrete EVs enriched with miR-379 for in vivo therapy of breast cancer. [Oncogene] Abstract

MicroRNA-99a Is a Novel Regulator of KDM6B-Mediated Osteogenic Differentiation of BMSCs

Scientists identified miR-99a and its target lysine-specific demethylase 6B (KDM6B) gene as novel modulators of osteogenic differentiation of bone mesenchymal stem cells (BMSCs). [J Cell Mol Med] Full Article

Redirecting Adult Mesenchymal Stromal Cells to the Brain: A New Approach for Treating CNS Autoimmunity and Neuroinflammation?

The authors explore the significant role of chemokine receptors and adhesion molecules in directing cellular traffic to the inflamed central nervous system (CNS) and the capacity of MSCs to adopt these molecular mechanisms to gain entry to this site. [Immunol Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

UF Launches New Center for Regenerative Medicine

The University of Florida (UF) has launched a Center for Regenerative Medicine to develop lifesaving therapies “to heal the body from within” using stem cells that repair damaged tissue and organs. [University of Florida] Press Release

Nikon Enters into a Business Alliance to Establish a Clinical-Use Master Cell Bank, to Be Utilized for Regenerative Medicine Products Derived from Dental Pulp Cells for the First Time in Japan

Nikon Corporation has announced a business alliance agreement with Advanced Cell Technology and Engineering Ltd. in order to establish a clinical-use master cell bank, to be employed for regenerative medicine products derived from dental pulp cells. [Nikon Corporation] Press Release

Computer Scientist to Lead French Research Giant; Interim Head Leaves Amid Misconduct Allegations

Computer scientist Antoine Petit, 57, is the new head of Europe’s largest research organization. There was an unusual twist to Petit’s appointment, however. A week before the official procedure ended, the French government named Petit interim president of the National Center for Scientific Research, a position that had been held by cell biologist Anne Peyroche since Fuchs’s departure. [ScienceInsider] Editorial

Gender Bias Goes Away When Grant Reviewers Focus on the Science

But female scientists suffer when their research proposals are judged primarily on the strength of their CVs. [Nature News] Editorial

NEW Advances in Cell and Tissue Culture (ACTC) 2018
May 21-23, 2018
Cardiff, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Human Lung Stem Cells and Regeneration (MedImmune)

PhD Students – Biomarkers for Chronic Disease (University of Hull)

Program Director – Translational Bone Research (Hospital for Special Surgery and Weill Cornell Medicine)

PhD Studentship – Regenerative Sciences (Hannover Biomedical Research School)

Tenure Track Assistant Professor – Cell Biology and Anatomy (University of South Carolina School of Medicine)

Assistant or Associate Professor – Orthopedics & Sports Medicine (University of Washington)

Postdoctoral Fellow – Bone and Stem Cells Biology (Stanford University)

Associate/Full Professor – Regenerative Medicine (University of Florida)

Postdoctoral Associate Positions – Translational Musculoskeletal Research (Penn State College of Medicine)

Postdoctoral Position – Stem Cell Differentiation (University of California, Berkeley)

Chair – Department of Cell and Regenerative Biology (University of Wisconsin)

Postdoctoral Scholar Position – Cancer & Stem Cell Epigenomics (University of California, Davis)

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