Mesenchymal Cell News Volume 10.05 | Feb 6 2018

TOP STORY

New Mouse Model Makes Stem Cells Light Up Green

Multipotent stromal cells have long been a hot topic in medical research. Scientists have now found a way to specifically mark these stem cells. This makes it possible to analyze their distribution pattern and their function in living organisms. [Press release from the University of Bonn discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

IN VITRO

Primary Cilia Are Dysfunctional in Obese Adipose-Derived Mesenchymal Stem Cells

The authors showed that adipose-derived mesenchymal stem cells (ASCs) from obese individuals have defective primary cilia, which are shortened and unable to properly respond to stimuli. [Stem Cell Reports] Full Article | Graphical Abstract

Differentiation of MSCs from Human iPSCs Results in Downregulation of c-Myc & DNA Replication Pathways with Immunomodulation toward CD4 & CD8 Cells

Using MSCs differentiated from induced pluripotent stem cells (iPSCs) reprogrammed using diverse cell types and protocols, and in comparison to human embryonic stem cel-MSCs and bone marrow-MSCs, the authors performed transcriptome analyses and assessed for functional immunomodulatory properties. [Stem Cells] Abstract

Spheroid-Cultured Human Umbilical Cord-Derived Mesenchymal Stem Cells Attenuate Hepatic Ischemia-Reperfusion Injury in Rats

Investigators compared 3D spheroid-cultured human umbilical cord (UC) derived MSCs with 2D-cultured UC-MSCs on treating hepatic ischemia-reperfusion injury . [Sci Rep] Full Article

Curcumin-Mediated Bone Marrow Mesenchymal Stem Cell Sheets Create a Favorable Immune Microenvironment for Adult Full-Thickness Cutaneous Wound Healing

In vitro cultured bone marrow-derived MSC (BMSC) sheets (CS-C) showed that curcumin promoted the proliferation of BMSCs and modified the features of produced extracellular matrix (ECM) secreted by BMSCs, especially the contents of ECM structural proteins such as fibronectin and collagen I and III, as well as the ratio of collagen III/I. [Stem Cell Res Ther] Full Article

The Role of Snf5 in the Osteogenic Differentiation Potential during Replicative Senescence of Rat Mesenchymal Stromal Cells

Investigators found that bone marrow-derived stromal cells at passage six showed marked decreases in the osteogenic differentiation potential and the level of Oct4. [Mech Ageing Dev] Abstract

Interactive Effects of LPS and Dentine Matrix Proteins on Human Dental Pulp Stem Cells

Scientists investigated the combinatorial effects of lipopolysaccharide (LPS) and extracted dentine matrix proteins on regenerative and inflammatory response in human dental pulp stem cells. [Int Endod J] Abstract

IN VIVO

Immunomodulation by Therapeutic Mesenchymal Stromal Cells (MSC) Is Triggered through Phagocytosis of MSC by Monocytic Cells

Researchers examined immunological mechanisms determining the fate of infused MSC and the immunomodulatory response associated with it. Tracking viable and dead human umbilical cord MSC (ucMSC) in mice using Qtracker beads and Hoechst33342 revealed that viable ucMSC were present in the lungs immediately after infusion. [Stem Cells] Abstract

Mesenchymal Stem Cells Over-Expressing cxcl12 Enhance the Radioresistance of the Small Intestine

MSCs are promising tools for carrying foreign genes to treat radiation-induced injuries in the intestinal epithelium. In this study, human adipose-derived MSCs were constructed to over-express the mouse cxcl12 gene to treat such injuries. [Cell Death Dis] Full Article

IL-6 Potentiates BMP-2-Induced Osteogenesis and Adipogenesis via Two Different BMPR1A-Mediated Pathways

Researchers showed that interleukin (IL)-6 injection enhances new bone regeneration and induces excessive adipose tissue formation in an recombinant human bone morphogenetic protein-2 (BMP-2)/absorbable collagen sponge-induced ectopic bone formation model in rats. [Cell Death Dis] Full Article

Tissue-Resident Mesenchymal Stromal Cells: Implications for Tissue-Specific Antifibrotic Therapies

The authors review recently characterized tissue-resident MSC populations with a prominent role in fibrosis and highlight therapeutically relevant molecular pathways regulating their activity in chronic disease. [Sci Transl Med] Abstract

Receptor Control in Mesenchymal Stem Cell Engineering

Scientists discuss materials-based bioengineering approaches to direct MSC fate in vitro and in vivo, mimicking cell–matrix–growth factor crosstalk. [Nat Rev Mater] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Anika Therapeutics Announces Strategic Collaboration with the Institute of Integrative Biology at the University of Liverpool to Develop an Innovative Therapy for Osteoarthritis

Anika Therapeutics, Inc. announced an agreement with the Institute of Integrative Biology at the University of Liverpool to collaborate on research to develop an injectable MSC therapy for the treatment of osteoarthritis. [Anika Therapeutics, Inc.] Press Release

RoosterBio Commercializes Industry’s First cGMP Human Mesenchymal Stem Cell Banks for Widespread Manufacturing, Continuing to Revolutionize Regenerative Medicine

RoosterBio.com continues to deliver on its mission to de-bottleneck and accelerate the Regenerative Medicine Industry by launching the only commercially-available working cell banks for large scale human MSC production. [RoosterBio Inc. (Vocus PRW Holdings, LLC.)] Press Release

Japanese Researchers Say Science-Budget Hike Isn’t Enough

Japan will sharply increase funding for science and technology in 2018 after years of stagnant support for the sector. But some scientists and policy experts worry the boost is too little to make up for more than a decade of lackluster science funding. [Nature News] Editorial

Pubmed Commons Closes Its Doors to Comments

The US National Institutes of Health announced that it will discontinue PubMed Commons, a tool that allows scientists to comment on articles indexed in the agency’s popular PubMed database of biomedical literature. The agency said low levels of engagement and the growth of alternate venues for public discussion of published papers contributed to its decision to close PubMed Commons after five years. [Nature News] Editorial

Nature Journals Tighten Rules on Non-Financial Conflicts

What makes a conflict of interest in science? Definitions differ, but broadly agree on one thing: an influence that can cloud a researcher’s objectivity. For some people, that influence can be money. But there are other influences that can interfere, such as institutional loyalty, personal beliefs and ambition. [Nature News] Editorial

NEW The New York Stem Cell Foundation (NYSCF) Conference 2018
October 23-24, 2018
New York, New York, United States

Visit our events page to see a complete list of events in the community.

NEW Scientist – Stem Cell and Regenerative Biology, (Moderna Therapeutics)

NEW Research Scientists/Postdoctoral Fellows – Biomaterial and Stem Cell Engineering (Brigham & Women’s Hospital)

NEW Principal Investigator – Cardiac Cell Repair (Boston Children’s Hospital)

Postdoctoral Fellow – Human Lung Stem Cells and Regeneration (MedImmune)

Program Director – Translational Bone Research (Hospital for Special Surgery and Weill Cornell Medicine)

PhD Studentship – Regenerative Sciences (Hannover Biomedical Research School)

Tenure Track Assistant Professor – Cell Biology and Anatomy (University of South Carolina School of Medicine)

Assistant or Associate Professor – Orthopedics & Sports Medicine (University of Washington)

Postdoctoral Fellow – Bone and Stem Cells Biology (Stanford University)

Postdoctoral Associate Positions – Translational Musculoskeletal Research (Penn State College of Medicine)

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