Mesenchymal Cell News Volume 10.08 | Feb 27 2018

TOP STORY

Periosteum Contains Skeletal Stem Cells with High Bone Regenerative Potential Controlled by Periostin

Scientists showed that periosteum contains skeletal stem cells with high bone regenerative potential compared to bone marrow stromal cells/skeletal stem cells in mice. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Potency Analysis of Mesenchymal Stromal Cells Using a Combinatorial Assay Matrix Approach

The authors tested two assay systems to measure the potency of MSCs derived from human subjects: MSC secretome analysis and a quantitative RNA-based array for genes specific to immunomodulatory and homing properties of MSCs. [Cell Rep] Full Article | Graphical Abstract

Meso-Endothelial Bipotent Progenitors from Human Placenta Display Distinct Molecular and Cellular Identity

From a heterogeneous placental single-cell suspension, a directly flow-sorted CD45⁻CD34⁺CD144⁺CD31Lo population uniquely differentiated into both endothelial and mesenchymal colonies in limiting dilution culture assays. [Stem Cell Reports] Full Article | Press Release | Graphical Abstract

TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells

Scientists investigated the effects of aging on human bone-derived MSCs expressing CD271 and SSEA-4 (double-positive MSCs [DPMSCs]). The percentages of DPMSCs in bone tissue decreased significantly with age. [Stem Cell Reports] Full Article | Graphical Abstract

Magnesium Enhances the Chondrogenic Differentiation of Mesenchymal Stem Cells by Inhibiting Activated Macrophage-Induced Inflammation

Researchers investigated the potential of magnesium to regulate macrophage polarization and macrophage-induced inflammation with or without lipopolysaccharide and interferon-γ activation and further elucidated whether these effects impact the inhibitory functions of activated macrophage-induced inflammation on cartilage regeneration. [Sci Rep] Full Article

Secreted Clusterin Protein Inhibits Osteoblast Differentiation of Bone Marrow Mesenchymal Stem Cells by Suppressing ERK1/2 Signaling Pathway

Investigators demonstrated that clusterin mRNA expression and protein secretion in conditioned medium increased during adipocyte differentiation and decreased during osteoblast differentiation of mouse bone marrow-derived skeletal stem cells. [Bone] Abstract

PD-1 Is Required to Maintain Stem Cell Properties in Human Dental Pulp Stem Cells

Scientists showed that neural crest-derived MSCs from dental pulp (MSC-DP), but not MSCs from bone marrow, expressed PD-1. Knocking down PD-1 expression in MSC-DP resulted in a significantly reduced capacity for cell proliferation and accelerated multipotential differentiation. [Differentiation] Abstract

IN VIVO

Immunomonitoring of MSC-Treated GvHD Patients Reveals Only Moderate Potential for Response Prediction but Indicates Treatment Safety

Researchers studied the immunological response to MSC treatment in 16 aGvHD patients by assessing lymphocyte profiles and three proposed aGvHD serum markers during the MSC treatment. [Mol Ther Methods Clin Dev] Abstract

TSG-6 Secreted by Bone Marrow Mesenchymal Stem Cells Attenuates Intervertebral Disc Degeneration by Inhibiting the TLR2/NF-κB Signaling Pathway

The authors investigated the effects of bone marrow MSCs and TNF-α-stimulated gene 6 protein (TSG-6) on intervertebral disc degeneration and explored the possible underlying mechanisms in vitro and in vivo. [Lab Invest] Abstract

Chaihulonggumulitang Shows Psycho-Cardiology Therapeutic Effects on Acute Myocardial Infarction by Enhancing Bone Marrow Mesenchymal Stem Cells Mobilization

Investigators explored the effects of chaihulonggumulitang on acute myocardial infarction and anxiety in vivo and in vitro. They also tested its effects in promoting bone marrow MSCs mobilization and alleviating inflammation. [Sci Rep] Full Article

The Genes Involved in Asthma with the Treatment of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells

Researchers evaluated the immunomodulatory effects of MSCs from human embryonic stem cells (hESCs) on asthma. The hESC-MSCs were analyzed for the expression of stem cell surface markers by flow cytometry, their differentiation potentials were analyzed using in vitro trilineage differentiation methods. hESC-MSCs were transplanted into the murine model with ovalbumin-induced airway allergic inflammation. [Mol Immunol] Abstract

Engineering Stem and Stromal Cell Therapies for Musculoskeletal Tissue Repair

The authors present recent clinical advances where stem cells and stromal cells have been used to stimulate musculoskeletal tissue repair, including delivery strategies to improve cell viability and retention. [Cell Stem Cell] Abstract

Mesenchymal Stem Cells in Multiple Myeloma: A Therapeutical Tool or Target?

Researchers focus on the current understanding of the biological role of MSCs in multiple myeloma as well as the potential utility of MSC-based therapies in this malignancy. [Leukemia] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

CollPlant Joins ReMDO’s Advanced Biomanufacturing Initiative for Development of a Universal BioInk for 3D Bioprinting of Tissues and Organs

CollPlant announced that it is part of ReMDO’s advanced biomanufacturing initiative for the development of a universal BioInk with tunable properties for 3D bioprinting of tissues and organs. [CollPlant (PR Newswire Association LLC)] Press Release

Primary Endpoint Successfully Achieved in Mesoblast’s Phase III Cell Therapy Trial for Acute Graft versus Host Disease

Mesoblast Limited announced that the Phase III trial of its allogeneic mesenchymal stem cell product candidate MSC-100-IV in children with steroid refractory acute Graft versus Host Disease has successfully met the primary endpoint of Day 28 overall response rate. [Mesoblast Limited] Press Release

Merkel Makes a Surprise Pick for German Research Minister

German Chancellor Angela Merkel isn’t known for her political surprises. But she managed a big one when she tapped Anja Karliczek, a 46-year-old lawmaker little known outside of party circles, as Germany’s next minister for education and research. [ScienceInsider] Editorial

Florida Residents Could Soon Get the Power to Alter Science Classes

Policymakers in the United States are pushing to give the public more power to influence what educators teach students. Florida’s legislature started considering two related bills that, if enacted, would let residents recommend which instructional materials teachers in their school district use in their classrooms. [Nature News] Editorial

One of the Most Powerful Science Policy Jobs in Brussels Changes Hands

It’s the end of an era at the European Commission’s research department: The most powerful civil servant in Brussels’s science policy circles, Director-General for Research and Innovation Robert-Jan Smits, is leaving his post. [ScienceInsider] Editorial

NEW 6^th Annual German Stem Cell Network (GSCN) Conference
September 19-21, 2018
Heidelberg, Germany

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Bone Biology and Osteoimmunology (Weill Cornell Medicine)

Postdoctoral Research Associate – Obstetrics and Gynecology (University of Illinois)

Senior Stem Cell Scientist – Tissue Engineering (VitroLabs Inc)

Full Professor Position – Cell and Developmental Biology (Max F. Perutz Laboratories)

Lectureship – Stem Cell Biology (University of Edinburgh)

Scientist – Stem Cell and Regenerative Biology, (Moderna Therapeutics)

Principal Investigator – Cardiac Cell Repair (Boston Children’s Hospital)

Program Director – Translational Bone Research (Hospital for Special Surgery and Weill Cornell Medicine)

PhD Studentship – Regenerative Sciences (Hannover Biomedical Research School)

Tenure Track Assistant Professor – Cell Biology and Anatomy (University of South Carolina School of Medicine)

Assistant or Associate Professor – Orthopedics & Sports Medicine (University of Washington)

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