Mesenchymal Cell News 10.10 March 13, 2018 | |
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TOP STORYThe authors prepared biodegradable polylactic acid (PLA) nanopillar arrays with different diameters but the same center-to-center distance using a series of anodic aluminum oxide nanowell arrays as templates. Human adipose-derived stem cells were selected to investigate the effect of the diameter of PLA nanopillar arrays on stem cell differentiation. [Nano Lett] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROResearchers investigated the cross-talk between bone marrow-derived mesenchymal stem cells (BM-MSCs) and osteosarcoma (OS) cells. They revealed a strong tropism of BM-MSCs towards these tumor cells, and identified MCP-1, GRO-α and TGF-β1 as pivotal factors for BM-MSC chemotaxis. [Mol Oncol] Abstract | Full Article Investigators applied a human MSC line, the KP cell, to serve as an in vitro model to study the effect of Midazolam on chondrogenesis. [J Cell Mol Med] Abstract Scientists enhanced the proliferations of aged bone marrow stem cells and adipose stem cells. They evaluated the shelf lives of clinical grade chondrogenically induced cells from both samples. [Sci Rep] Full Article A significant increase in hDPSC proliferation and ALP activity that stimulated mineralization of the hDPSC-generated matrix was seen on gelatin-HA-TCP scaffolds compared with the gelatin-only scaffolds. In addition, RT-PCR revealed that the gelatin-HA-TCP scaffold up-regulated gene expression of the osteogenic markers Runx2, BSP and OSX. [J Biomed Mater Res A] Abstract IN VIVOTransplantation of encapsulated wild-type MSCs greatly prolonged the survival of the heart allograft compared with encapsulated Rap1−/−-MSCs. [Cell Death Dis] Full Article The authors demonstrated that regeneration of esophageal tissue is feasible and reproducible in a large animal model using synthetic polyurethane electro-spun grafts seeded with autologous adipose-derived MSCs and a disposable bioreactor. [Sci Rep] Full Article | Press Release Investigators explored the influence of radial shockwaves on human bone marrow MSCs using a floating model in vitro and evaluated the healing effects of these cells on cartilage defects in vivo using a rabbit model. [Stem Cell Res Ther] Full Article 15-leucine-rich repeat containing membrane protein (LRRC15) expression was upregulated upon osteogenic induction, and the level of LRRC15 was significantly decreased in ovariectomized mice. Both in vitro and in vivo experiments detected that LRRC15 was required for osteogenesis of MSCs. [Stem Cell Res Ther] Full Article miR-218 was confirmed to promote osteogenic differentiation of MSCs by stimulating the alkaline phosphatase activity, calcium nodule formation, and osteogenic marker gene expression. [Calcif Tissue Int] Abstract | |
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REVIEWSMesenchymal Stem Cells: Potential Application for the Treatment of Hepatic Cirrhosis Scientists review the strategies for enhancing the homing of MSCs, mainly via the delivery routes, optimizing cell culture conditions, stimulating the target sites, and genetic modification. [Stem Cell Res Ther] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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SCIENCE NEWSLongeveron Shares Latest Advances to Treat Aging Frailty Longeveron Co-Founder Joshua Hare provided the latest updates on how the company’s mesenchymal stem cell therapy continues to generate promise for treating aging frailty, Alzheimer’s disease and other conditions associated with aging. [Press release from Longeveron LLC (PR Newswire Association LLC) discussing research presented at the International Conference on Frailty and Sarcopenia Research (ICFSR), Miami] Press Release | |
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INDUSTRY NEWSMiMedx Group, Inc. announced that the FDA has granted MiMedx’s micronized amniotic tissue, AmnioFix® Injectable, the RMAT designation for use in the treatment of osteoarthritis of the knee. [MiMedx Group, Inc. (PR Newswire Association LLC)] Press Release Company that Develops Injectable Bone Grafts Expands Clinical Trial Bonus Biogroup Ltd. announced on the launch of a new clinical trial to test its injectable bone grafts in 30-40 patients. The permits for the trial, which will test the grafts in people suffering from critical bones loss in their arms or legs, were received after three pilot patients that received the grafts in the past few months showed promising recovery results. [CTECH] Press Release | |
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POLICY NEWSRussian Science Chases Escape from Mediocrity After letting Russian science languish for years, Vladimir Putin has started to pay more attention. At a meeting of the Council for Science and Education last month, the Russian president promised that science and innovation are now top priorities. [Nature News] Editorial University Strikes to Continue after Staff Reject Pension Offer Strikes at UK universities are to continue after staff overwhelmingly rejected a revised offer on their pensions. [The Guardian] Editorial Key Republican Lawmaker Releases New ‘Right-to-Try’ Legislation A key Republican lawmaker released a new version of so-called “right to try” legislation, a pivotal next step in the effort to help dying patients get access to experimental therapies. [STAT News] Editorial
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EVENTSNEW LabRoots: 2nd Annual Cell Biology Virtual Event Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Skeletal Stem Cell Biology (Johns Hopkins University) NEW Faculty Position – Stem Cell Biology and Regenerative Medicine (University of Illinois) Postodoctoral Fellowship – Cell and Molecular Biology (Canadian Nuclear Laboratories) Postdoctoral Researcher – Cell Biology (University of Pennsylvania) Postdoctoral Fellow – Bone Biology and Osteoimmunology (Weill Cornell Medicine) Postdoctoral Research Associate – Obstetrics and Gynecology (University of Illinois) Full Professor Position – Cell and Developmental Biology (Max F. Perutz Laboratories) Lectureship – Stem Cell Biology (University of Edinburgh) Scientist – Stem Cell and Regenerative Biology, (Moderna Therapeutics) Principal Investigator – Cardiac Cell Repair (Boston Children’s Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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