Mesenchymal Cell News 10.11 March 20, 2018 | |
| |
TOP STORYScientists showed that Fas binds with Fas-associated phosphatase-1 (Fap-1) and caveolin-1 (Cav-1) to activate a common soluble N-ethylmaleimide–sensitive factor attachment protein receptor-mediated membrane fusion mechanism to release small extracellular vesicles in MSCs. [Sci Transl Med] Abstract | Press Release | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)IN VITROThe authors investigated the effects of secretome-enriched conditioned medium of neuronally differentiated PC12 cells on the neuronal differentiation of human MSCs. [Mol Neurobiol] Abstract Investigators used a real microgravity environment of the SJ-10 Recoverable Scientific Satellite to examine the effects of space microgravity on the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. [FASEB J] Abstract Matrix Elasticity Regulates Mesenchymal Stem Cell Chemotaxis The authors probed the efficiency of epidermal growth factor-induced human MSC chemotaxis on substrates of varying stiffness inside a PDMS microfluidic device. [J Cell Sci] Abstract Scientists report that inhibition of 2,5-hexanedione (HD)-induced autophagy contributed to bone marrow-MSC (BMSC)-afforded protection. BMSC transplantation significantly reduced the levels of microtubule-associated protein 1 light chain 3-II and the degradation of sequestosome-1 in the spinal cord and sciatic nerve of HD-intoxicated rats. [Sci Rep] Full Article Matrix Stiffness Modulates Mesenchymal Stem Cell Sensitivity to Geometric Asymmetry Signals Researchers employed microcontact printing to create patterned symmetric and asymmetric hydrogel islands of soft and hard surface stiffness. Human MSCs were confined to these islands at the single-cell level and given the ability to differentiate along adipogenic or osteogenic routes. [Ann Biomed Eng] Abstract Investigators showed that rabbit subchondral bone is a reliable source of MSCs. They harvested subchondral bone (SCB) from the rabbit knee-joint and initiated the MSC culture by cultivating enzyme-treated SCB. [Exp Anim] Abstract | Full Article IN VIVOResearchers investigated the effects of intravenous administration of C16 and angiopoietin-1 on the efficacy of placenta-derived MSC transplantation in a rat model of experimental allergic encephalomyelitis (EAE). [Sci Rep] Full Article The authors investigated a cell-free approach via conditioned medium from rat bone marrow stromal cells applied intrathecally for spinal cord injury recovery in adult rats. [Int J Mol Sci] Full Article Researchers investigated the potential of apparent diffusion coefficient for monitoring adipose-derived MSC therapy of renal ischemic-reperfusion injury. [Mol Imaging Biol] Abstract | |
| |
REVIEWSThe authors present biological properties of MSCs of bone marrow origin and a heterogeneous population of muscle-resident stem/progenitor cells, their interaction with the inflammatory environment of dystrophic muscle and potential implications for cellular therapies for muscle regeneration. [Arch Immunol Ther Exp] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
| |
SCIENCE NEWSCellular Biomedicine Group Inc. announced 48-week clinical data from the Phase I clinical trial in China for its allogeneic adipose-derived mesenchymal progenitor cell off-the-shelf therapy AlloJoin™ for KOA. [Press release from Cellular Biomedicine Group Inc. discussing research presented at the 2018 B. Riley FBR Inaugural China Healthcare Investing & Partnering Symposium (CHIPS) Conference, Hangzhou] Press Release | |
| |
INDUSTRY NEWSBoehringer Ingelheim and Vanderbilt University announced the expansion of their successful existing collaboration to develop novel anti-cancer compounds. The expanded research partnership will focus on the discovery and development of new chemical therapeutics targeting the pro-survival protein MCL1 as a potential therapy against MCL1-dependent cancers. [Vanderbilt University] Press Release CGT Catapult to Support UK Network of Advanced Therapies Treatment Centers The Cell and Gene Therapy (CGT) Catapult will support three UK sites awarded funding to form a network of advanced therapies treatment centers – joint ventures set up to include industry, academic and NHS partners, and funded by Innovate UK. [The Cell and Gene Therapy Catapult] Press Release | |
| |
POLICY NEWSChinese Leaders Create Super Science Ministry Chinese leaders released plans to expand the powers of the country’s science and technology ministry. The beefed-up agency will continue to oversee science policy and major projects, but will take on extra responsibilities for funding research grants and for recruiting foreign scientists. [Nature News] Editorial Reporter’s Notebook: House Budget Hearing Shows Science Chairman’s Impact on NSF Peer Review Representative Lamar Smith has repeatedly criticized the peer-review process at the National Science Foundation (NSF) in Alexandria, Virginia, since becoming chairman of the U.S. House of Representatives’s science committee in 2013. It was no surprise, then, that during a hearing on NSF’s 2019 budget request he railed against a handful of grants from NSF’s $6 billion research portfolio as a waste of taxpayer dollars. [ScienceInsider] Editorial
| |
EVENTSNEW Cell Symposia: Translation of Stem Cells to the Clinic: Challenges and Opportunities Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Research Assistant – Stem Cell Biology in Critical Limb Ischemia (NUI Galway) NEW Postdoctoral Positions – Bioengineering (George Washington University) Postdoctoral Fellowship – Skeletal Stem Cell Biology (Johns Hopkins University) Faculty Position – Stem Cell Biology and Regenerative Medicine (University of Illinois) Postodoctoral Fellowship – Cell and Molecular Biology (Canadian Nuclear Laboratories) Postdoctoral Researcher – Cell Biology (University of Pennsylvania) Postdoctoral Fellow – Bone Biology and Osteoimmunology (Weill Cornell Medicine) Postdoctoral Research Associate – Obstetrics and Gynecology (University of Illinois) Full Professor Position – Cell and Developmental Biology (Max F. Perutz Laboratories) Lectureship – Stem Cell Biology (University of Edinburgh) Scientist – Stem Cell and Regenerative Biology, (Moderna Therapeutics) Principal Investigator – Cardiac Cell Repair (Boston Children’s Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Mesenchymal Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|