Mesenchymal Cell News Volume 10.22 | Jun 5 2018

TOP STORY

Tissue Mimicry in Morphology and Composition Promotes Hierarchical Matrix Remodeling of Invading Stem Cells in Osteochondral and Meniscus Scaffolds

Monolithic osteochondral and meniscus scaffolds enabled rapid cell ingrowth and induced zonal‐specific matrix synthesis of human multipotent MSCs solely through their design without the need for supplementation of soluble factors such as growth factors. [Adv Mater] Abstract

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IN VITRO

Tet1 and Tet2 Maintain Mesenchymal Stem Cell Homeostasis via Demethylation of the P2rX7 Promoter

Scientists showed that depletion of ten-eleven translocation (Tet)1 and Tet2 results in impaired self-renewal and differentiation of bone marrow MSCs and a significant osteopenia phenotype. [Nat Commun] Full Article

Transformation of Amorphous Polyphosphate Nanoparticles into Coacervate Complexes: An Approach for the Encapsulation of Mesenchymal Stem Cells

MSCs grown onto the polyphosphate coacervate showed enhanced growth/proliferation and became embedded in the coacervate. [Small] Abstract

Role of Wnt11 during Osteogenic Differentiation of Human Mesenchymal Stem Cells on Microstructured Titanium Surfaces

Researchers demonstrated that Wnt11 is a mediator of osteoblast commitment of MSCs, and increases in a surface-roughness dependent manner. Experiments using cells silenced for Wnt11 indicated that cross-talk between Wnt5a and Wnt11 occurs. Wnt11 potentially acts upstream to Wnt5a, increasing Wnt5a expression and factors associated with osteogenesis. [Sci Rep] Full Article

Time‐Dependent Contribution of BMP, FGF, IGF, and HH Signaling to the Proliferation of Mesenchymal Stroma Cells during Chondrogenesis

The authors identified the contribution of bone morphogenetic protein (BMP), fibroblast growth factor (FGF), insulin‐like growth factor (IGF), and hedgehog (HH) signaling toward cell proliferation during chondrogenesis and investigated whether a further mitogenic stimulation is possible and promising. [J Cell Physiol] Abstract

Zinc Promotes Osteoblast Differentiation in Human Mesenchymal Stem Cells via Activation of the cAMP-PKA-CREB Signaling Pathway

Researchers investigated the effects of zinc on osteoblast differentiation in human bone marrow-derived MSCs and to identified the molecular mechanisms of these effects. [Stem Cells Dev] Abstract

Vitamin D3 Contributes to Enhanced Osteogenic Differentiation of MSCs under Oxidative Stress Condition via Activating the Endogenous Antioxidant System

Investigators demonstrated that vitamin D3 (Vd3) could significantly attenuate the H₂O₂-induced cell injury of MSCs via Sirt1/FoxO1 signaling pathway, and reduced the H₂O₂ exposure-induced intracellular oxidative stress status of MSCs. [Osteoporos Int] Abstract

3D Bioprinted Artificial Trachea with Epithelial Cells and Chondrogenic-Differentiated Bone Marrow-Derived Mesenchymal Stem Cells

Rabbit bone marrow-derived mesenchymal stem cells (bMSC) and rabbit respiratory epithelial cells were cultured. The chondrogenic differentiation level of bMSC cultured in regular media and that in chondrogenic media were compared. [Int J Mol Sci] Full Article

IN VIVO

BMPRIA Is Required for Osteogenic Differentiation and RANKL Expression in Adult Bone Marrow Mesenchymal Stromal Cells

Investigators specifically ablated Bmpr1a in bone marrow MSCs in adult mice to study the function of BMPR1A in bone remodeling and found that the mutant mice showed an increase in cancellous and cortical bone mass, which was accompanied by a decrease in bone formation rate and a greater decrease in bone resorption. [Sci Rep] Full Article

miR-10a Rejuvenates Aged Human Mesenchymal Stem Cells and Improves Heart Function after Myocardial Infarction through KLF4

In vivo, transplantation of miR-10a-overexpressed aged human bone marrow MSCs promoted implanted stem cell survival and improved cardiac function after myocardial infarction. [Stem Cell Res Ther] Full Article

Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities

In this perspective, important biological and pharmacological disparities in pre-clinical research and human translational studies are highlighted, and analyses of clinical trial failures and recent successes provide a rational pathway to MSC regulatory approval and deployment for disorders with unmet medical needs. [Cell Stem Cell] Abstract

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Cynata’s Cymerus^™ MSCs Effective in Preclinical Model of Diabetic Wounds

Cynata Therapeutics Limited announced that it has received positive data demonstrating the efficacy of its Cymerus^™ MSCs in a preclinical model of diabetic wounds. [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] Press Release

The United States Patent and Trademark Office (USPTO) Awards Estar Medical a New Patent on its Innovative Platelet-Rich Plasma (PRP) Technology

Estar Technologies Ltd. announced that the USPTO granted to Estar Medical, US Patent No. 9,962,480 (480 Patent), with claims directed, among others, to a medical separator system for the preparation of PRP. The 480 patent describes closed preparation systems and methods for preparing, among others, PRP, enriched MSCs, enriched bone marrow stem cells, and the combination with a range of other biologics, including hyaluronic acid, thrombin, autologous stem cells and others. [Estar Technologies Ltd.] Press Release

Europe’s Top Science Funder Shows High-Risk Research Pays Off

A popular and unusual self-review carried out by Europe’s most prestigious science funder is back. The annual assessment, now in its third year, found that nearly one in five projects by the European Research Council led to a scientific breakthrough. [Nature News] Editorial

‘Right-to-Try’ Law Intended to Weaken the FDA, Measure’s Sponsor Says in Blunt Remarks

Sen. Ron Johnson, the author of the federal “right-to-try” law signed by President Trump this week, wants to make one thing clear: His new law is meant to weaken the FDA. “This law intends to diminish the FDA’s power over people’s lives, not increase it,” he wrote in a letter to Commissioner Scott Gottlieb. [STAT News] Editorial

NEW ComBio 2018
September 23-26, 2018
Sydney, Australia

Visit our events page to see a complete list of events in the community.

NEW Research Associate – Advanced Cell Culture Biology (The University of Manchester)

NEW Experimental Postdoctoral Position – Single-Cell Functional Genomics (Heidelberg University)

Postdoctoral Researcher – Stem Cell Based Regenerative Medicine (Karolinska Institutet)

Postdoctoral Positions – Cell Biology (Children’s Hospital of Philadelphia)

Postdoctoral Research Assistant – Cell Biology (University of Oxford)

Postdoctoral Researcher – Skeletal Cell Metabolism in Bone Pathology and Regeneration (KU Leuven)

Senior Lecturer – Cell Biology and Genetics (University of Chicago)

Postdoctoral Position – Cell Biology (University of Houston)

Review Scientists – Gene and Cell Therapy (Center for Biologics Evaluation and Research)

Postdoctoral Fellow/Senior Scientist – Aortic Aneurysm and Postnatal Bone Growth (Icahn School of Medicine at Mount Sinai)

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