Mesenchymal Cell News Volume 10.25 | Jun 26 2018

TOP STORY

Inhibition of MicroRNA-138 Enhances Bone Formation in Multiple Myeloma Bone Marrow Niche

Researchers showed that expression of miR-138 was significantly increased in MSCs from multiple myeloma patients and myeloma cells compared to those from healthy subjects. [Leukemia] Abstract

(Ranked by impact factor of the journal)

IN VITRO

Clonal Analysis Delineates Transcriptional Programs of Osteogenic and Adipogenic Lineages of Adult Mouse Skeletal Progenitors

Investigators established mouse clonal skeletal progenitors with distinct differentiation properties and analyzed their transcriptome. Unipotent osteogenic and adipogenic cells expressed specific transcriptional programs, whereas bipotent clones combined expression of those genes and did not show a unique signature. [Stem Cell Reports] Full Article | Graphical Abstract

Suppressing Mesenchymal Stem Cell Hypertrophy and Endochondral Ossification in 3D Cartilage Regeneration with Nanofibrous Poly(l-Lactic Acid) Scaffold and Matrilin-3

The authors seeded bone marrow-derived MSCS on the nanofibrous poly(l-lactic acid) scaffold with or without matrilin-3 (MATN3). They found that MATN3 suppressed hypertrophy in this 3D culture system in vitro. [Acta Biomater] Abstract | Graphical Abstract

Bacterial Nanocellulose Stimulates Mesenchymal Stem Cell Expansion and Formation of Stable Collagen-I Networks as a Novel Biomaterial in Tissue Engineering

Scientists used label-free, non-invasive multiphoton microscopy to characterize bacterial nanocellulose – a promising biomaterial for bone tissue engineering – and their potency to stimulate collagen-I formation by MSCs. [Sci Rep] Full Article

Inhibition of the RhoGTPase Cdc42 by ML141 Enhances Hepatocyte Differentiation from Human Adipose-Derived Mesenchymal Stem Cells via the Wnt5a/PI3K/miR-122 Pathway: Impact of the Age of the Donor

Cdc42 activity in undifferentiated human adipose-derived MSCs showed an age-dependent significant increase in Cdc42-GTP correlated to a decrease in Cdc42GAP; the low potentials of cell proliferation, doubling, adherence, and immunomodulatory ability contrary to the apoptotic index of the aged group were significantly reversed by ML141. [Stem Cell Res Ther] Full Article

Gelatin-Based Microribbon Hydrogels Accelerate Cartilage Formation by Mesenchymal Stem Cells in 3D

Compared to conventional hydrogels, macroporous gelatin-based microribbon scaffolds significantly increased the total amount of neocartilage produced by MSCs in 3D, with improved interconnectivity and mechanical strength. [Tissue Eng Part A] Abstract

ZNF521 Has an Inhibitory Effect on the Adipogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells

The authors documented through the analysis of a panel of human adipose-derived stem cells, that zinc finger protein 521 (ZNF521) strongly inhibited the generation of mature adipocytes. Enforced overexpression of ZNF521 in these cells resulted in a significant delay and reduction in adipocyte differentiation upon exposure to inducers of adipogenesis. [Stem Cell Rev] Abstract

Inhibin α‐Subunit Inhibits BMP9‐Induced Osteogenic Differentiation through Blocking BMP/Smad Signal and Activating NF‐κB Signal in Mesenchymal Stem Cells

Researchers investigated the role of inhibin‐α on BMP9‐induced osteogenic differentiation in MSCs and tried to discover the mechanism underlying this process. They found that inhibin‐α apparently reduced the classical osteogenic markers and the ectopic bone formation induced by BMP9. [J Cell Biochem] Abstract

IN VIVO

Bone Marrow-Derived Mesenchymal Stem/Stromal Cells Reverse the Sensorial Diabetic Neuropathy via Modulation of Spinal Neuroinflammatory Cascades

MSC transplantation inhibited multiple parameters of spinal neuroinflammation found in diabetic mice, causing the reduction of activated astrocytes and microglia, oxidative stress signals, galectin-3, IL-1β, and TNF-α production. [J Neuroinflammation] Full Article

Fibrin Glue-Aided, Instant Epicardial Placement Enhances the Efficacy of Mesenchymal Stromal Cell-Based Therapy for Heart Failure

The authors explored the role of fibrin glue-aided, instant epicardial placement to enhance the efficacy of MSC-based therapy in a rat ischemic cardiomyopathy model. [Sci Rep] Full Article

Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis

Investigators examined the biodistribution and the efficacy of intraperitoneal luciferase-expressing human expanded adipose-derived stem cells (Luci-eASCs) in a mouse model of colitis. Luci-eASC-infused mice were stratified according to their response to the Luci-eASC treatment. [Int J Mol Sci] Full Article

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The Current Understanding of Mesenchymal Stem Cells as Potential Attenuators of Chemotherapy‐Induced Toxicity

The authors present a concise review of the published data regarding the influence of various classes of chemotherapeutic agents on the survival, stem cell characteristics and physiological functions of MSCs. Molecular mechanisms underlying the effects are outlined, and resulting challenges of MSC‐based treatments for chemotherapy‐induced tissue injuries are discussed. [Int J Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Key Day 100 Survival Outcomes of Phase III Trial for Acute Graft versus Host Disease Presented

Mesoblast Limited announced key Day 100 survival outcomes of its Phase III trial for remestemcel-L, an allogeneic MSC product candidate, in children with steroid refractory acute graft versus host disease. [Press release from Mesoblast Limited (GlobeNewswire, Inc.) discussing research presented at the International Society for Stem Cell Research (ISSCR) Annual Meeting, Melbourne] Press Release

SurgaColl Partners with Sparta to Deliver High-Quality Tissue Regeneration Products, Improve Accessibility and Time-to-Market

Sparta Systems, Inc. announced it is partnering with SurgaColl^™ Technologies, an innovative medical device company supplying novel orthobiologics products for the surgical treatment of disease and regeneration of bone and cartilage tissues. [Sparta Systems, Inc.] Press Release

NuVasive Launches AttraX Scaffold Biologic and Reports First Clinical Use

NuVasive, Inc. announced the U.S. launch of AttraX^® Scaffold, an absorbent ceramic-collagen bone graft with an optimized surface that has been validated in preclinical testing to drive increased bone formation and faster fusion than traditional ceramic bone grafts. The AttraX surface technology, through its carefully defined and tightly controlled features at the submicron scale, drives the differentiation of MSCs into bone-forming osteoblasts without added growth factors. [NuVasive, Inc.] Press Release

Cynata Reports Positive 28-Day Data from Cohort B of Phase I Trial of CYP-001 in GvHD

Cynata Therapeutics Limited announced positive safety and efficacy data from a day 28 analysis of patients in Cohort B of its Phase I clinical trial of CYP-001, the company’s lead Cymerus^™ MSC product candidate, in steroid-resistant acute graft versus host disease (GvHD). [Cynata Therapeutics Limited] Press Release

Worrying Changes in Hungary

The European country’s autocratic government has made a disturbing grab at the nation’s scientific institutions. [Nature News] Editorial

Senate Panel Proposes $2 Billion, 5.4% Increase for NIH

A U.S. Senate appropriations subcommittee approved a spending bill that calls for giving the National Institutes of Health (NIH) a $2 billion, 5.4% increase to $39.1 billion in the 2019 fiscal year that begins 1 October. [ScienceInsider] Editorial

White House Proposes a Narrowing of FDA’s Mission — And a New Name

The Trump administration has proposed a fundamental change to the mission of the FDA, one that would transfer most of the responsibility for regulating food safety to the Department of Agriculture and rename the FDA the “Federal Drug Administration”. [STAT News] Editorial

US–Chinese Trade War Puts Scientists in the Cross Hairs

Scientific research in the United States could become collateral damage in the country’s escalating trade dispute with China. Both countries went head-to-head in mid-June over tariffs on a long list of goods that includes lab equipment and reagents. That is likely to increase the cost of scientific research, and the impact could be felt more keenly in US labs. [Nature News] Editorial

NEW 2018 Till & McCulloch Meetings (TMM2018)
November 12-14, 2018
Ottawa, Ontario, Canada

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Assistant – Stem Cell Based Regenerative Medicine (Queen Mary University of London)

Research Fellow – Stem Cell Biology and Engineering (New York Blood Center)

Research Assistant – Cell Culture and Engineering (University of Oxford)

Canada Excellence Research Chair – Cardiac Regeneration (University of Toronto and The Hospital for Sick Children)

Research Associate – Advanced Cell Culture Biology (The University of Manchester)

Experimental Postdoctoral Position – Single-Cell Functional Genomics (Heidelberg University)

Postdoctoral Researcher – Stem Cell Based Regenerative Medicine (Karolinska Institutet)

Postdoctoral Positions – Cell Biology (Children’s Hospital of Philadelphia)

Postdoctoral Research Assistant – Cell Biology (University of Oxford)

Postdoctoral Position – Cell Biology (University of Houston)

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