Mesenchymal Cell News 10.30 July 31, 2018 | |
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TOP STORYResearchers investigated whether exosomes from human umbilical cord MSCs (hucMSC-ex) had therapeutic effect on type 2 DM (T2DM). HucMSC-ex partially reversed insulin resistance in T2DM indirectly to accelerate glucose metabolism. HucMSC-ex inhibited streptozotocin induced β-cell apoptosis to restore the insulin secreting function of T2DM. [ACS Nano] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROGenome-Scale CRISPR-Cas9 Screen Identifies Druggable Dependencies in TP53 Wild-Type Ewing Sarcoma The stapled peptide inhibitor of MDM2 and MDM4, ATSP-7041, showed anti-tumor efficacy in vitro and in multiple mouse models. The USP7 inhibitor, P5091, and the Wip1/PPM1D inhibitor, GSK2830371, decreased the viability of Ewing sarcoma cells. The combination of ATSP-7041 with P5091, GSK2830371, and chemotherapeutic agents showed synergistic action on the p53 pathway. [J Exp Med] Abstract | Graphical Abstract Very few studies report gentle dissociation of MSCs undergoing an osteodifferentiation process. Here investigators used this technique to reveal the presence of several cell layers during osteogenesis and to study their different properties. [Stem Cell Res Ther] Full Article The mRNA expressions of endothelial cell markers CD31, von Willebrand Factor, vascular endothelial growth factor receptor-2, and CD34 were significantly increased in softer gelatin methacrylate (GelMA) hydrogels (7.5% and 10%) compared to stiffer matrices (15% GelMA). [J Tissue Eng Regen Med] Abstract A static magnetic field of 1 mT increased dental pulp stem cell (DPSC) proliferation, as well as the gene expression of several growth factors such as FGF-2, TGF-β and VEGF. The static magnetic field promoted the migration of DPSCs by regulating MMP-1 and MMP-2 gene expression. 1 mT of static magnetic field also induced osteo/odontogenesis and mineralization in DPSCs. [J Tissue Eng Regen Med] Abstract IN VIVOA Lox/CHOP-10 Crosstalk Governs Osteogenic and Adipogenic Cell Fate by MSCs Investigators found that lysyl oxidase (Lox) inhibition dramatically up-regulated BMP4-induced expression of CCAAT/enhancer binding protein homologous protein 10 (CHOP-10), which then promoted BMP4-induced osteogenesis of MSCs both in vitro and in vivo. [J Cell Mol Med] Full Article Endoscopic Transplantation of Mesenchymal Stem Cell Sheets in Experimental Colitis in Rats Researchers investigated the feasibility and utility of intraluminal endoscopic transplantation of rat MSC sheets in murine models of experimental colitis for targeted delivery of stem cells to lesions. The adipose-derived-MSC group showed decreased inflammation and colitis in the transplanted regions. [Sci Rep] Full Article Adipose-derived MSCs (ADSC) were successfully transplanted forming a graft-like gel film covering the infarct myocardium. Echocardiography and magnetic resonance imaging revealed improved cardiac performance of the ADSC group at 4 and 8 weeks after transplantation. Histological examination showed significantly attenuated left ventricular remodeling and a greater vascular density in the infarct border area in the ADSC group. [Transplantation] Abstract Scientists established new methods for differentiating human induced pluripotent stem cells into MSCs via mesoderm-like and neuroepithelium-like cells. Both derived MSC populations exhibited self-renewal and multipotency, as well as therapeutic potential in mouse models of skin wounds, pressure ulcers, and osteoarthritis. [PLoS One] Full Article Researchers analyzed the effect of CD146+ cells compared to MSCs derived from the same human adipose sample when injected in a double knockout mice mouse model without immunosuppression. Both CD146+ cells and MSCs increased the survival of treated mice when compared to vehicle-injected mice, with a more prominent effect of CD146+ cells than MSCs. [DNA Cell Biol] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSFibroblasts as a Practical Alternative to Mesenchymal Stem Cells The authors put forward the concept that in some cases, fibroblasts may be utilized as a more practical, and potentially more effective cell therapy than mesenchymal stem cells. Anti-inflammatory, immune modulatory, and regenerative properties of fibroblasts are discussed in the context of regenerative medicine. [J Transl Med] Full Article | Press Release Current Advances for Bone Regeneration Based on Tissue Engineering Strategies Investigators describe the cell sources, biology of seed cells, growth factors, vascular development, and the interactions of relevant molecules. They also discuss the challenges and perspectives that may propel the direction of future clinical delivery in bone regeneration. [Front Med] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSA new partnership between Medicine by Design and the Creative Destruction Lab (CDL), founded at the Rotman School of Management, will strengthen Toronto’s biomedical ecosystem by bringing together the University of Toronto’s world-class research in regenerative medicine and the CDL’s proven seed-stage program for science-based companies. [Rotman School of Management] Press Release CCRM Receives $15M from Government of Canada The Centre for the Commercialization of Regenerative Medicine (CCRM) has been awarded $15 million from the Networks of Centres of Excellence program to continue with its efforts to generate sustainable health and economic benefits for Canadians through global collaboration in regenerative medicine technologies, and cell and gene therapies [The Centre for the Commercialization of Regenerative Medicine] Press Release BrainStorm Announces Grant of a New European Patent for NurOwn® BrainStorm Cell Therapeutics Inc. announced that the European Patent Office has granted an European-wide patent entitled ‘Mesenchymal Stem Cells for the Treatment of CNS Diseases’ for the treatment of amyotrophic lateral sclerosis with NurOwn®>/sup>. [BrainStorm Cell Therapeutics Inc.] Press Release | |
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POLICY NEWSElsevier/Impactstory Agreement Will Make Open Access Articles Easier to Find on Scopus With Elsevier’s new partnership with Impactstory, researchers will soon be able to find open access content on Scopus more efficiently. Meanwhile, for university research offices, the expansion of OA-identified content in Scopus will enable improved strategic analysis and benchmarking. [Elsevier] Editorial Springer Nature Creates New Role to Lead On Research Integrity As one of the largest publishers of academic research, Springer Nature has developed a new position of Research Integrity Director to ensure the growing volume of scientific content being published continues to be rigorously assessed, with robust processes in place to prevent and address research misconduct and breaches of publication ethics. [Springer Nature] Editorial Government of Canada further Strengthens Science and Encourages Scientists to Speak About Their Work The Honourable Kirsty Duncan, Minister of Science and Sport, and the Honourable Scott Brison, President of the Treasury Board and Minister of Digital Government, welcomed the Model Policy on Scientific Integrity. The new policy will be shared with federal departments and agencies that employ scientists and researchers. These departments and agencies will use the model policy to develop their own scientific integrity policies that meet their departmental and employee needs. [Government of Canada] Editorial
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EVENTSNEW Gordon Research Conference: Vascular Cell Biology Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Fellow – Stem Cell Biology (Washington University School of Medicine in St. Louis) PhD Student Positions – Regenerative Medicine (University Medical Center Utrecht) Senior Lecturer – Stromal Immunology (University of Aberdeen) Faculty Position – Cellular Physiology and Engineering (Mayo Clinic) Research Fellow – Stem Cell Biology and Engineering (New York Blood Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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