Mesenchymal Cell News 10.34 August 28, 2018 | |
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TOP STORYDeciduous Autologous Tooth Stem Cells Regenerate Dental Pulp after Implantation into Injured Teeth Investigators showed that implantation of autologous tooth stem cells from deciduous teeth regenerated dental pulp with an odontoblast layer, blood vessels, and nerves in two animal models. Human deciduous pulp stem cell implantation, but not apexification treatment, led to regeneration of three-dimensional pulp tissue equipped with blood vessels and sensory nerves at 12 months after treatment. [Sci Transl Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROBone marrow stromal stem cells from patients with ethanol-induced osteonecrosis exhibited weaker osteogenic differentiation and proliferation abilities. Tumor necrosis factor α (TNF-α), by regulating miR-31, downregulated the expressions of RUNX2 and SATB2, two contributors of osteoblast differentiation, further suppressed osteogenic differentiation. [J Cell Physiol] Abstract Investigators employed human MSCs as an evaluation system to assess bisphenol A (BPA)-related effects on cell viability, oxidative stress induction, self-renewal, and differentiation. Low concentrations of BPA did not impair cell proliferation nor self-renewal capacity, but stimulated adipogenesis and osteogenesis. [Ecotoxicol Environ Saf] Abstract | Graphical Abstract Synovium-derived and infrapatellar fat pad-derived MSCs displayed substantial proliferation ability, and the four cell populations studied underwent trilineage differentiation. During chondrogenesis, the wet weight was heavier for cartilage pellets derived from synovium MSCs than from the other three sources. [PLoS One] Full Article Dual luciferase reporter assay indicated that miR-134 directly targeted the 3′-UTR of SMAD6, and inhibited miR-134 expression in bone marrow MSCs upregulated SMAD6 expression. The authors found that overexpression of SMAD6 significantly promoted chondrogenic differentiation, and this SMAD6 induced promotion of chondrogenic differentiation could be reversed by miR-134 mimics. [Biosci Rep] Abstract | Full Article Using a high-throughput microwell platform, investigators demonstrated that bone marrow-derived MSCs (BMSCs) in 3D microtissue culture resulted in tissue compaction, rather than growth, not all mineralised bone-like matrix was incorporated in the bulk microtissue mass, and a significant amount of lipid vacuole formation was observed in BMSC microtissues exposed to BMP-2. [Cell Tissue Res] Full Article IN VIVOPre-Vascularization in Fibrin Gel/PLGA Microsphere Scaffolds Designed for Bone Regeneration To address the issue of insufficient vascularization within scaffolds designed to promote bone regeneration, scientists developed a pre-vascularized scaffold to enable the repair of large alveolar bone defects. Peripheral blood-derived MSCs seeded into fibrin gel/poly(lactic-co-glycolic acid) (PLGA) microsphere scaffolds with fibrin gel tended to migrate to the surface of PLGA microspheres and expressed high levels of osteogenic markers. [NPG Asia Mater] Full Article In mice with atopic dermatitis (AD), superoxide dismutase 3-transduced MSCs ameliorated AD pathology and enhanced the efficacy of MSC therapy by controlling activated immune cells, reducing expression levels of pro-inflammatory mediators in the skin, and by inhibiting the histamine H4 receptor-mediated inflammatory cascade and activation of Janus kinase-signal transducer and activator of transcription pathways. [Allergy] Abstract Researchers developed an improved method for generating mismatched humanized mice, using a dual infusion of human hematopoietic stem and progenitor cells (HSPCs) and MSCs, isolated from cord blood and expanded in vitro. Engraftment with both HSPCs and MSCs produced mice with almost twice the percentage of human immune cells in their bone marrow, compared to mice engrafted with HSPCs alone. [Mol Carcinog] Abstract | Press Release An Allogenic Therapeutic Strategy for Canine Spinal Cord Injury Using Mesenchymal Stem Cells Bone marrow-derived MSCs were evaluated for allogenic therapeutic potential in 44 clinical cases of spinal cord injuries and compared with conventional therapy. Therapeutic potential as evaluated by different body reflexes and recovery score depicted significantly better results in the stem cell-treated group compared to control group. [J Cell Physiol] Abstract Investigators reported that the expression of paired box 2 (Pax2) gradually increased during osteogenic differentiation of mouse MSCs, and osteoprogenitor cells. Knock-down of Pax2 repressed mouse MSCs-mediated bone regeneration in an ectopic bone formation model. [Exp Cell Res] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSRegulation Effects of Melatonin on Bone Marrow Mesenchymal Stem Cell Differentiation The authors summarize the evidence related to the utility of melatonin as a regulatory agent by focusing on its relationship with the differentiation of MSCs. In particular, they review its roles in promoting osteogenic and chondrogenic differentiation and the relevant signaling cascades involved. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSOrgenesis Inc. along with BGN Technologies and the National Institute for Biotechnology in the Negev announced a collaboration to develop and commercialize a novel alginate scaffold technology for cell transplantation, with an initial focus on autoimmune diseases. [Orgenesis Inc.] Press Release Swedish Government and GE Healthcare Open an Innovation Center for Life Sciences The Swedish government and GE Healthcare are opening Testa Center – an innovation center in Uppsala, Sweden, to boost the commercialization of new technologies and support manufacturing capabilities in the life sciences sector. [General Electric] Press Release | |
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POLICY NEWSIndia Targets Universities in Predatory-Journal Crackdown Most academics regard predatory journals as an irritant – if not a threat – to science. But in India, some universities have recommended the inclusion of such publications in the country’s ‘white list’ of approved journals. Now the government is cracking down on this practice, which scientists say came about as a result of perverse government incentives. [Nature News] Editorial NIH Investigating Whether U.S. Scientists Are Sharing Ideas with Foreign Governments Fears that foreign governments are tapping U.S.-funded research for valuable information have reached the nation’s largest research funder, the National Institutes of Health (NIH) in Bethesda, Maryland. The NIH sent a letter to more than 10,000 research institutions, urging them to ensure that NIH grantees are properly reporting their foreign ties. [ScienceInsider] Editorial US Senate Passes Spending Bill Granting NIH $39.1 Billion The US Senate passed a spending bill allotting $39.1 billion to the National Institutes of Health (NIH) for the 2019 fiscal year starting on October 1. [The Scientist] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2019 Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Interdisciplinary (Oregon Health & Science University) Faculty Positions – Biomedical Research (Memorial Sloan Kettering Cancer Center) Postdoctoral Research Fellow – Spinal Fusion (Hopkins Spinal Fusion Laboratory) Postdoctoral Fellow – Stem Cell Biology (Washington University School of Medicine in St. Louis) Senior Lecturer – Stromal Immunology (University of Aberdeen) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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