Mesenchymal Cell News 10.41 October 16, 2018 | |
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TOP STORYITGBL1 Modulates Integrin Activity to Promote Cartilage Formation and Protect against Arthritis Scientists found that developing chondrocytes expressed integrin-β-like 1 (Itgbl1) at specific stages, inhibiting integrin signaling and promoting chondrogenesis. Unlike cytosolic integrin inhibitors, ITGBL1 was secreted and physically interacted with integrins to down-regulate activity. [Sci Transl Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROHuman bone marrow-derived mesenchymal stem cells were cultured on tissue culture plates and 3D printed polycaprolactone (PCL) scaffolds coated with cellulose nanofibrils material (CNF). CNF significantly enhanced the hydrophilic properties of PCL scaffolds and promoted protein adsorption. [Biomacromolecules] Abstract Perinatal nicotine exposure resulted in decreased oil red O staining, triolein uptake, expression of PPARγ and its downstream target gene ADRP by bone marrow-derived MSCs, but enhanced αSMA and fibronectin expression, and activated Wnt signaling, all features indicative of their inhibited lipogenic, but enhanced myogenic potential. [Clin Sci (Lond)] Abstract The Interplay between Adipose-Derived Stem Cells and Bladder Cancer Cells Researchers observed a substantial increase in the concentration of IL-6 and IL-8 in the secretome of adipose-derived stem cells (ASCs) co-cultured with bladder cancer cells. Concentrations of GM-CSF, MCP-1 and RANTES were also elevated. Bioactive molecules produced by ASCs increased the viability of 5637 and HT-1376 cells by respectively 15.4% and 10.4%. [Sci Rep] Full Article A new method for titanium (Ti) surface modification involving a graphene oxide (GO) coating and aspirin (Archive) loading (A/Ti-GO) was developed, and the bioactive effects on mouse osteoblastic MC3T3-E1 cells were preliminarily studied. The A/Ti-GO surface displayed a significantly higher proliferation rate and differentiation of MC3T3-E1 cells into osteoblasts, which was confirmed by a water-soluble tetrazolium salt-8 assay and alkaline phosphatase activity test. [Sci Rep] Full Article Short-Term Physiological Hypoxia Potentiates the Therapeutic Function of Mesenchymal Stem Cells Human and porcine bone marrow MSCs were obtained from fresh mononuclear cells. The first study evaluated MSC function following both long-term and short-term hypoxia culture. In the second study, investigators evaluated the functional characteristics of MSC cultured under short-term 2% and 5% hypoxia. [Stem Cell Res Ther] Full Article A Dual Role of Cholesterol in Osteogenic Differentiation of Bone Marrow Stromal Cells. Scientists found that exogenous cholesterol significantly inhibited alkaline phosphatase activity and messenger RNA (mRNA) expression of osteoblast markers genes while modestly activating expression of Gli1 under both basal osteogenic culture condition and Wnt3a treatment. [J Cell Physiol] Abstract Researchers reported an antisense Long noncoding RNAs SEMA3B-AS1 regulating human MSCs osteogenesis. SEMA3B-AS1 was proximal to a member of the semaphorin family Sema3b. Overexpression of SEMA3B-AS1 using the lentivirus system markedly inhibited the proliferation of hMSCs and reduced osteogenic differentiation. [J Cell Physiol] Abstract IN VIVOIn vivo cellular interactions of primary human MSC in co-culture with human SK-OV-3 ovarian cancer cells revealed an increased tumor growth as compared to mono-cultures of the ovarian cancer cells. The presence of MSC stimulated formation of liver metastases. Further interactions of MSC with the ovarian cancer cells resulted in the formation of hybrid cells by cell fusion. [Cell Commun Signal] Full Article The level of IL-6 in bronchoalveolar lavage fluid was measured by ELISA. Real-time quantitative PCR was used to analyze mRNA of IL-6 and tumor necrosis factor-α. Human adipose tissue-derived stromal cells (hADSCs) treatment increased survival rate of septic mice with mechanical ventilation. hADSCs attenuated dysfunction of the liver and kidney and decreased lung inflammation and tissue injury of the liver and lung. [Inflammation] Abstract TGF-β2 Downregulates Osteogenesis under Inflammatory Conditions in Dental Follicle Stem Cells Osteogenic differentiation of inflamed dental follicle stem cells (DFSCs) resulted in decreased alkaline phosphatase activity and alizarin red S staining compared to normal DFSCs. Additionally, in vivo transplantation of inflamed and normal DFSCs demonstrated severe impairment of osteogenesis by inflamed DFSCs. [Int J Oral Sci] Full Article | |
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REVIEWSStem Cells under the Influence of Alcohol: Effects of Ethanol Consumption on Stem/Progenitor Cells Stem cells drive embryonic and fetal development. In several adult tissues, they retain the ability to self-renew and differentiate into a variety of specialized cells, thus contributing to tissue homeostasis and repair throughout life span [Cell Mol Life Sci] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSRoosterBio, Inc. Earns NIIMBL Nod with 2 Grant Awards for Regenerative Medicine Manufacturing The overarching initiative represents approximately $14 million worth of activity over 18 months and involves 24 unique NIIMBL member organizations, including Regenerative Medicine industry vanguard, RoosterBio, Inc. [Cision Ltd (Rooster Bio, Inc. (Vocus PRW Holdings, LLC.))] Press Release Mesoblast Limited announced that it has entered into a strategic alliance with one of China’s largest pharmaceutical companies, Tasly Pharmaceutical Group, for the development, manufacture and commercialization in China of Mesoblast’s allogeneic mesenchymal precursor cell (MPC) product candidates MPC-150-IM for the treatment or prevention of chronic heart failure and MPC-25-IC for the treatment or prevention of acute myocardial infarction.” [Mesoblast Limited (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSThe UK Pharmaceutical Industry Braces for Brexit As Britain’s departure date from the European Union approaches, drugmakers are preparing for potential changes to regulatory procedures and border controls. [The Scientist] Editorial Report: Former CNRS President Guilty of Fraud The French Alternative Energies and Atomic Energy Commission has found that cell biologist Anne Peyroche, deputy director of the organization’s Molecular Genetics Laboratory who also served interim president of National Center for Scientific Research, was complicit in the publication of falsified data, according to a report revealed by French news magazine L’Express. [The Scientist] Editorial
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EVENTSNEW TOBI X: 10th Annual PRP & Regenerative Medicine Symposium, Workshops & Cadaver Labs Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Professor (all ranks) – Synthetic and Systems Biology (Arizona State University) PhD Positions/ Early Stage Researcher Positions – EU Horizon 2020 MSCA-ITN Project (Renal Tool Box) Assistant Professor – Department of Stem Cell and Regenerative Biology (Harvard University) Postdoctoral Fellows – Regenerative Medicine (Stanford University) Faculty Positions – Biomedical Engineering (Pennsylvania State University) Tenure Track Assistant Professor – Regenerative Biology (Massachusetts General Hospital) Tenure-Track Faculty Position – Stem Cell Biology (Children’s Research Institute at UT Southwestern) Assistant Professor – Stem Cell and Regenerative Biology (Columbia University) Postdoctoral Researcher – Interdisciplinary (Oregon Health & Science University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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