Mesenchymal Cell News 10.45 November 13, 2018 | |
| |
TOP STORYWhile the established parental p53Mut-MSCs induced tumors, the parental p53WT-MSCs that were established in parallel, did not. Furthermore, tumor lines derived from the parental p53Mut-MSCs, exhibited a more aggressive transformed phenotype, suggesting exacerbation in tumorigenesis. [Cell Death Differ] Full Article | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)IN VITROSingle MSCs from patients with multiple myeloma had changes in expression of genes associated with cellular proliferation and senescence and a higher proportion of senescent cells and lower proliferative potential than those from age-matched healthy donors. Single MSCs from both sources heterogeneously expressed MSC genes associated with adipogenesis and osteoblastogenesis. [Br J Haematol] Abstract Connective tissue progenitors (CTPs) obtained from the femur of patients undergoing total hip replacement by two harvest techniques-bone marrow (BM) aspiration and BM collection-after bone rasping were immunophenotyped by flow cytometry and evaluated for chondrogenic ability. The spatial localization of different CTP subsets in BM was verified by immunohistochemistry. [Am J Sports Med] Full Article The authors established a cell fusion model between lung cancer cells and MSCs in vitro. They found that the hybrid cells showed enhanced metastatic capacity with increased expression of MMP-2 and MMP-9, whereas the proliferation ability was inhibited and cell cycle was blocked in the G0/G1 phase with elevated expression of p21, p27, and p53. [J Cell Physiol] Abstract Small Non-Coding RNA Expression in Mouse Nephrogenic Mesenchymal Progenitors Investigators describe a miRNA expression in nephrogenic mesenchymal progenitors, with 162 miRNAs differentially expressed in progenitors when compared to whole kidney. They also annotated 49 novel miRNAs in the developing kidney and experimentally validated four of them. [Sci Data] Full Article IN VIVOHuman bone marrow stromal cell and HUVEC spheroids were implanted within a bone defect site to determine the osteogenic potential of the skeletal-endothelial cell unit. Cells were pelleted as co- or monocell spheroids and placed within 1-mm-drill defects in the mid-diaphysis of embryonic day 18 chick femurs and cultured organotypically for 10 days. [FASEB J] Abstract Researchers confirmed that after in vivo glioblastoma (GBM) tumor establishment, by stereotaxic implantation of the CD133+ GBM cells labeled with Qdots, MSCs labeled with multimodal iron oxide nanoparticles conjugated to rhodamine-B, infused by caudal vein, were able to cross the blood-brain barrier of the animal and migrate to the tumor region. [Stem Cell Res Ther] Full Article Scientists evaluated the effectiveness of combination therapy of human bone marrow-derived MSCs with minocycline in a middle cerebral artery occlusion rat model. Neurological outcome in the adhesive-removal test and rotarod test and modified neurological severity score were better in the combination therapy group than in the monotherapy and control groups. [Stem Cell Res Ther] Full Article Deletion of Nicotinic Acetylcholine Receptor Alpha9 in Mice Resulted in Altered Bone Structure Investigators analyzed the bone of adult female knockout (KO) mice with single deletion of either nicotinic acetylcholine receptor alpha9 (α9KO) or α10KO. Biomechanical testing showed a significant decrease of bending stiffness and maximal breaking force in α9KO compared to their corresponding wild type mice. [Bone] Full Article Scientists showed that delivery of murine adipose-derived stem cells (ADSC) or bone marrow-derived MSCs (BMSC) increased diabetic healing similarly, compared with acellular controls. They showed similarly increased cellular proliferation, VEGF expression, capillary density, numbers of macrophages and smooth muscle cells with ADSC or BMSC treatment. [Am J Physiol Cell Physiol] Abstract Researchers showed that resistin treatment promoted adipose-derived MSCs (ADSC) myocardial homing three days after intravenous injection. They showed that ADSC-resistin, but not ADSC-vehicle, significantly improved the left ventricular ejection fraction. In addition, cardiomyocyte apoptosis was reduced while angiogenesis was increased by ADSC-resistin treatment. [Am J Physiol Heart Circ Physiol] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
| |
REVIEWSPathogenic Stromal Cells as Therapeutic Targets in Joint Inflammation Knowledge of the physiological and pathological mechanisms that involve joint MSCs has begun to cast new light on why joint inflammation persists. The shared embryological origins of fibroblasts and endothelial cells might shape the behavior of these cell types in diseased adult tissues. [Nat Rev Rheumatol] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
| |
SCIENCE NEWSBioCardia®, Inc. announced positive 12 month data for the roll-in cohort of its pivotal CardiAMP™ Heart Failure Trial studying the investigational CardiAMP Cell Therapy System in adult patients experiencing heart failure following a heart attack. [Press release from BioCardia, Inc. discussing research presented at the American Heart Association Scientific Sessions 2018, Chicago] Press Release Calidi Biotherapeutics Announces Two Abstracts Accepted for Presentation Calidi Biotherapeutics, Inc. announced that data from its clinical studies in late-stage cancer patients will be presented. These two presentations will highlight how Calidi’s platform will significantly potentiate oncolytic virotherapy by using either autologous or a more scalable, off-the-shelf, allogeneic MSC-based delivery technology. [Press release from Calidi Biotherapeutics, Inc. discussing research presented at the Society for Immunotherapy of Cancer (SITC) 33rd Annual Meeting, Washington D.C] Press Release | |
| |
INDUSTRY NEWSInstitute of Scientific and Technical Information of China-Taylor & Francis Research Lab Launches A jointly established Research Lab will provide a grant to finance research projects on a specific annual topic, focusing on areas of key importance to the Chinese research community and providing an opportunity to drive significant change on issues most affecting Chinese researchers. [Taylor & Francis Group] Press Release Transformational Gift Benefits Harvard Medical School To accelerate the pace of therapeutic discovery and support initiatives aimed at solving some of humanity’s most acute biomedical challenges, Harvard University announced that the Blavatnik Family Foundation has committed $200 million to Harvard Medical School. [Harvard Medical School] Press Release Mesoblast Defends Stem Cell Therapy for Heart Failure after Trial Miss Mesoblast’s stem cell-based therapy was unable to reduce heart failure patients’ reliance on a left ventricular assist device (LVAD) in a Phase II trial. The Australian biotech said the trial showed that injections of MPC-150-IM (mesenchymal precursor cells) into the myocardium when the LVAD was implanted were not able to wean patients off the devices entirely, which it put down to blood clots in the devices that reduced the number of attempts. [Mesoblast Ltd (FierceBiotech)] Press Release MedCity Moves to Foster U.K. Advanced Therapy Collaborations MedCity has created an advanced therapies network to connect industry to academia. The initiative is seeking to build on the progress of British cell and gene therapy university spinouts such as Autolus and Orchard Therapeutics. [MedCity (FierceBiotech)] Press Release | |
| |
POLICY NEWSMore Researchers Denied UK Entry to Attend Meetings A number of researchers seeking to attend scientific and medical meetings in the UK in recent weeks have had their visa applications denied by the British government. [The Scientist] Editorial China’s Crackdown on Genetics Breaches Could Deter Data Sharing China’s enormous population is a genetics goldmine. But the government, wary that this data could be exploited for profit, has been cracking down on researchers and companies that violate rules on sharing its citizens’ genetic material and information. [Nature News] Editorial Be Open about Drug Failures to Speed Up Research Access to evidence from disappointing drug-development programs advances the whole scientific process, explain Enrica Alteri and Lorenzo Guizzaro. [Nature News] Editorial
| |
EVENTSNEW 15th Annual Stem Cell Symposium: Stem Cells B2B – Bench to Bedside Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Biomaterials Engineering (Karolinska Institute) Associate Professor/Professor – Regenerative Medicine or Stem Cell Biology (University of Toronto) Postdoctoral Researcher – Tissue Engineering & Organs on a Chip (OHSU School of Dentistry) Professor – Stem Cell & Regenerative Medicine (University College London) Faculty Position – Department of Biochemistry & Molecular Biology (Mayo Clinic) Postdoctoral Fellowships – Nanomedicine & Biomedical Engineering (University of British Columbia) PhD Positions/ Early Stage Researcher Positions – EU Horizon 2020 MSCA-ITN Project (Renal Tool Box) Assistant Professor – Department of Stem Cell and Regenerative Biology (Harvard University) Faculty Positions – Biomedical Engineering (Pennsylvania State University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Mesenchymal Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|