Mesenchymal Cell News 10.47 November 27, 2018 | |
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TOP STORYConditional knockout of rank in bone marrow MSCs with Prx1-Cre mice led to higher bone mass and increased trabecular bone formation independent of osteoclasts. In addition, rankflox/flox: Prx1-Cre mice showed resistance to ovariectomy-induced bone loss. [Bone Res] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROThe authors demonstrated that miR675 promoted malignant transformation of human MSCs. They revealed that miR675 enhanced the expression of the polyubiquitin-binding protein p62. P62 competed with SETD2 to bind histone H3 and then significantly reduced SETD2 binding capacity to substrate histone H3, triggering drastic reduction of three methylation on histone H3 thirty-sixth lysine. [Mol Ther Nucleic Acids] Abstract | Full Article In normal bone marrow (BM)-MSCs, lncAIS interacted with NF90 to promote HOXD8 mRNA stability that enhanced RUNX2 transcription in BM-MSCs, leading to osteogenic differentiation of normal BM-MSCs. [Cell Death Differ] Abstract Osteoinhibition was recapitulated in the model by co-culturing osteogenically enhanced human MSCs with a bone-tumor cell line that secretes the canonical Wnt inhibitor Dkk-1, a tumor-borne osteoinhibitory factor widely associated with several forms of malignant bone disease, or intact tumor fragments from Dkk-1 positive patient-derived xenografts. [Cell Death Dis] Full Article miR-16-2* Interferes with WNT5A to Regulate Osteogenesis of Mesenchymal Stem Cells Upregulation of miR-16-2* in human bone marrow MSCs impaired osteogenic differentiation while the downregulation of miR-16-2* increased this process. Furthermore, knockdown of miR-16-2* could promote the activation of RUNX2, possibly by lifting the inhibitory effect of miR-16-2* on the WNT pathway. [Cell Physiol Biochem] Full Article Investigators demonstrated that the proportion of cells expressing adrenergic receptor isoforms did not differ significantly in hTERT-MSCs compared to the primary adipose tissue-derived (ad) MSC culture. However, using analysis of Ca2+-mobilization in single cells, they found that these cells did not demonstrate the sensitization seen in primary adMSCs. [Int J Mol Sci] Full Article | Graphical Abstract IN VIVOBone Marrow-Derived Fibroblasts Are a Functionally Distinct Stromal Cell Population in Breast Cancer Scientists report that bone marrow (BM)-derived MSCs were recruited to primary breast tumors and to lung metastases and differentiated to a distinct subpopulation of cancer-associated fibroblasts (CAFs). Unlike resident CAFs, BM-derived CAFs did not express PDGFRα, and their recruitment resulted in a decrease in the percentage of PDGFRα-expressing CAFs. [J Exp Med] Full Article | Press Release | Graphical Abstract Researchers assessed the effect of cisplatin chemotherapy on attention using the 5-choice serial reaction time task and on synaptic integrity. They also assessed the capacity of MSCs to normalize the characteristics of chemobrain. [Sci Rep] Full Article A mouse model for long-term infertility was developed and used to transplant spermatogonial stem cells (SSCT), MSCs, a combination of SSCs and MSCs (MS-SSCT), or a combination of SSCs and TGFß1-treated MSCs (MSi-SSCT). Tubular fertility index after MSi-SSCT was significantly higher compared to MS-SSCT but did not differ statistically compared to SSCT. [Stem Cell Res Ther] Full Article Scientists found that M2, rather than M1 macrophages, promoted myofibroblast differentiation of lung resident (LR)-MSCs. They demonstrated that suppression of the Wnt/β-catenin signaling pathway could attenuate myofibroblast differentiation of LR-MSCs induced by M2 macrophages and bleomycin-induced pulmonary fibrosis. [Cell Commun Signal] Full Article Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSThe authors summarize the mechanism and role of miRNA transfer in mediating the effects of MSC-extracellular vesicles (EVs) in the models of human diseases. They provide existing evidence that MSC-EVs affect the outcomes of renal, liver, heart, and brain diseases by transferring their miRNA contents. [Stem Cell Res Ther] Full Article Scaffold Structural Microenvironmental Cues to Guide Tissue Regeneration in Bone Tissue Applications Investigators review advances in fabrication technology that enable the creation of biomaterials with well-defined pore structure and surface topography, which can be sensed by host tissue cells and subsequently determine cell fates during differentiation. [Nanomaterials (Basel)] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSUA Researchers Study How to Regrow Long Bone Segments Using 3D Printing Dr. Szivek, a biomedical engineer and professor of orthopedic surgery, has received a five-year, $2 million grant from the U.S. Department of Defense to launch a study to determine how to heal bone fractures using a combination of 3D printing and adult stem cells. [University of Arizona] Press Release AAAS Honors Accomplished Scientists as 2018 Elected Fellows The American Association for the Advancement of Science (AAAS) has bestowed upon 416 of its members the lifetime honor of being an elected Fellow in recognition of their extraordinary achievements in advancing science. [American Association for the Advancement of Science] Press Release | |
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POLICY NEWSBiomedical Research Is Becoming More Open about Its Funding and Data Biomedical research is shifting to become more open and transparent by providing increasing amounts of information about funding, conflicts of interest and data sharing in their publications, according to a survey of recent papers. [Nature News] Editorial European Funders Detail Their Open-Access Plan Plan S, the contentious plan that a group of European science funders hopes will end scholarly journals’ paywalls, has fleshed out its rules—and softened its tone a bit. In seven pages of implementation guidance released, the funders explain how their grantees can abide by Plan S rules come 2020, when it goes into effect. But some critics say the document—which is up for public discussion for the next two months—remains too restrictive. [ScienceInsider] Editorial A 100th Birthday Wish: Uphold Academic Freedom in Dark Times One hundred years ago this month, shortly after the guns of the First World War fell silent, a German-speaking Scottish lawyer-turned-politician sent an 80-page report to his prime minister. In it was an idea whose echo still shapes the way in which many nations fund research — an idea arguably as important to the soul of modern science as the secular state is to modern democracy. [Nature News] Editorial
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