Mesenchymal Cell News 10.48 December 4, 2018 | |
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TOP STORYAutocrine Regulation of Mesenchymal Progenitor Cell Fates Orchestrates Tooth Eruption Scientists showed that the parathyroid hormone-related peptide (PTHrP)-PTH/PTHrP receptor autocrine signal maintained physiological cell fates of dental follicle mesenchymal progenitor cells to establish the functional periodontal attachment apparatus and orchestrated tooth eruption. [Proc Natl Acad Sci USA] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROBICD1 Mediates HIF1α Nuclear Translocation in Mesenchymal Stem Cells during Hypoxia Adaptation Bicaudal D homolog 1 (BICD1) silencing abolished hypoxia-induced glycolytic reprogramming and increased mitochondrial ROS accumulation and apoptosis in umbilical cord blood-derived-MSCs under hypoxia. [Cell Death Differ] Full Article Inorganic poly-phosphate (poly-P) as a natural-based molecule was used to induce Wnt/β-catenin signaling in adipose-derived MSCs while cultured on 2D and 3D culture systems. Investigators showed that Cyclin-D1 and β-catenin gene expression was significantly increased in those cells treated by poly-P. [Artif Cells Nanomed Biotechnol] Abstract Stem cells from the apical papilla were fabricated as scaffold-free spheroids and were induced into forming calcified 3D constructs. The calcified density of the spheroidal constructs was enhanced when the spheroids were pretreated with LY294402 and rapamycin. [Stem Cell Res Ther] Full Article The authors tested the cytoskeletal changes and migration ability of bone marrow MSCs (BMSCs) after treatment with recombinant human BMP-2 (rhBMP-2). They explored the recruitment of BMSCs from the circulatory system using a collagen sponge incorporating rhBMP-2 that was implanted in vivo. [Biomater Sci] Abstract | Graphical Abstract Researchers evaluated the effects of bone morphogenetic protein (BMP)2/7 heterodimers on osteoblastic differentiation in rat bone marrow MSCs (BMSCs), with the aim to elaborate how mitogen-activated protein kinases might be involved in this cellular process by treatment of rat BMSCs with BMP2/-7 with a special signal-pathway inhibitor. [J Cell Biochem] Abstract IN VIVOIn myelodysplastic syndromes and de novo acute myeloid leukaemia-bone marrow MSCs (BMMSC), 5-azacitidine (Aza) treatment resulted in a pronounced serine protease inhibitor kunitz-type2 (SPINT2/HAI-2) levels up-regulation. Aza treatment of healthy donor-BMMSC did not improve SPINT2/HAI-2 levels. [J Cell Mol Med] Full Article Scientists characterized the stemness and demonstrated the multilineage potency of synovial fluid (SF)-MSCs in vitro. Intra-articular injections of xenogenic SF-MSCs exerted neither chondroprotection nor inflammation in anterior cruciate ligament transection-induced osteoarthritis in the rat knee. [Stem Cell Res Ther] Full Article Autologous MSC were isolated from bone marrow and cultured for two weeks. Prior to injection, MSC were attached on collagen microcarriers for delivery, with or without TGF-β1 crosslinking. After decompressive spinal surgery, dogs received an intradiscal injection of MSC-microcarriers, MSC-TGF-β1-microcarriers or microcarriers only. [Cell Transplant] Full Article Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSMeshes in a Mess: Mesenchymal Stem Cell-Based Therapies for Soft Tissue Reinforcement The authors summarize in vitro and in vivo studies involving the use of differentiated and MSCs in combination with surgical meshes. According to preclinical and clinical studies and considering the therapeutic potential of MSCs, it is expected that these cells will become valuable tools in the treatment of pathologies requiring tissue reinforcement. [Acta Biomater] Abstract | Graphical Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSStem Cell Bid Set to Tackle Osteoarthritis Patients with osteoarthritis could be set to benefit from an inventive stem cell technique being tested by doctors. The research focuses on harnessing the capabilities of the patient’s own cells to repair damaged joint tissue. Experts say, if successful, the technique could pave the way for treatments that would reduce the need for people having to have invasive surgery. [The University of Edinburgh] Press Release £6.5 million of funding has been awarded by Barts Charity to Queen Mary University of London to transform the Charterhouse Square campus at Barts and The London School of Medicine and Dentistry, and provide modern, cutting-edge teaching and medical research facilities. [Queen Mary University of London] Press Release | |
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POLICY NEWSResearchers Sign Petition Backing Plans to End Paywalls More than 1,400 researchers have signed an online letter backing the principles of Plan S, the bold open-access initiative led by research agencies who say that, by 2020, papers resulting from their funding should be immediately free to read on publication. [Nature News] Editorial Trump Emphasizes Workforce Training in New Vision for Stem Education The U.S. government needs to partner with industry and community organizations to train more Americans for jobs in an increasingly high-tech work environment. That’s the key message in a new 5-year strategic plan for science, technology, engineering, and math (STEM) education released by U.S. President Donald Trump’s administration. [ScienceInsider] Editorial Data Sharing in Action: When Drug Companies Open Their Trial Vaults Clinical trials generate tons of data that never see the light of day, but an initiative spearheaded by researchers at Yale University is trying to change that. Since 2011, the Yale University Open Data Access Project has developed a platform that allows external researchers to gain access to clinical trials data from pharmaceutical companies. [The Scientist] Editorial
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EVENTSNEW EMBO-EMBL Symposia: Synthethic Morphogenesis: From Gene Circuits to Tissue Architecture Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Stem Cell Genomics & Tissue Engineering (Friedrich Miescher Laboratory) NEW PhD Positions – Bone Healing & Soft-Tissue Inflammation (University of Gothenburg) NEW Assistant Professor – Department of Biological Sciences (Rutgers University Newark) Tenure Track Assistant Professor – Center for Regenerative Medicine (Massachusetts General Hospital) Postdoctoral Position – Regenerative Medicine, Stem Cells & Bioengineering (Igenomix Foundation) Associate Professor/Professor – Regenerative Medicine or Stem Cell Biology (University of Toronto) Postdoctoral Researcher – Tissue Engineering & Organs on a Chip (OHSU School of Dentistry) Faculty Position – Department of Biochemistry & Molecular Biology (Mayo Clinic) Postdoctoral Fellowships – Nanomedicine & Biomedical Engineering (University of British Columbia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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