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Pulmonary Cell News| Mesenchymal Cell News 10.49 December 11, 2018 | |
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TOP STORYAdministration of MSCs protected lung from ventilator-induced injury, while it worsened acid-primed lung injuries associated with fibrotic development in lung environment that had high levels of IL-6 and fibronectin along with low antioxidant capacity. [Am J Respir Crit Care Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROMicrogravity-Induced Hepatogenic Differentiation of rBMSCs on Board the SJ-10 Satellite Rat bone marrow-derived MSCs (BMSCs) were cultured and induced in hepatogenic induction medium for three and ten days in custom-made space cell culture hardware. Cell growth was monitored periodically in orbit, and the fixed cells and collected supernatants were retrieved back to the Earth for further analyses. [FASEB J] Abstract The potential regulation of “immune memory” in nonclassic immune cells, such as MSCs, has not been reported. In the current study, researchers chose IFN-γ plus TNF-α restimulation-induced iNOS expression as a model of MSC activation, because IFN-γ and TNF-α play crucial roles in MSC-mediated immunomodulation. [FASEB J] Abstract The impact of conjugation of biomimetic aspartic acid and glutamic acid templated peptides with poly(lactic-co-glycolic acid) electrospun nanofiber on osteogenic differentiation of human bone marrow-derived MSCs was evaluated. [Sci Rep] Full Article IN VIVOThe Long Noncoding RNA ORLNC1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Fate Scientists found ORLNC1, a functionally undefined lncRNA which is highly conserved exhibited markedly higher expression levels in bone marrow-derived MSCs, bone tissue and the serum of OVX-induced osteoporotic mice than sham-operated counterparts. [Mol Ther] Abstract Bone marrow-derived MSCs from host rats were transduced with an adenoviral vector labelled with green fluorescent protein to overexpress hepatocyte growth factor. The therapeutic effect of these modified stem cells transplanted intravenously into hepatocirrhosis model rats treated with CCl4 was evaluated using serological, biochemical and histological approaches. [Cell Death Dis] Full Article Delivery of cells with nanofiber mesh provided a unique topography that enabled entrapment of therapeutic cells for up to six weeks that promoted substantial cellular infiltration of host anti-inflammatory macrophages. As a result, degradation rate and tissue integration were highly impacted by endometrial SUSD2+ MSCs, revealing an unexpected level of implant integration over six weeks in vivo. [Biomacromolecules] Abstract Compared with allogeneic-adipose-derived MSCs (allo-ADMSCs), autologous-ADMSCs showed lower immunogenicity and evoked weaker immunological responses. Allo-ADMSCs evoked significantly stronger protein expression of interleukin-2 and interferon-gamma, as well as the local accumulation of CD4+ T lymphocytes, CD8+ T lymphocytes, and microglial cells. [J Transl Med] Full Article Investigators showed that the human adipose-derived MSCs (hADMSCs) treated group had a more rapid recovery in terms of thymic pathologic structure and function. The hADMSCs could home to the damaged thymus and secrete cytokines that played important roles in repairing damaged thymus. [Stem Cells Dev] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSAdipose-Derived Stem Cells for Wound Healing Advantages and disadvantages of various stem cells which can be used for promoting wound healing are discussed. In addition, potential mechanisms of action by which adipose-derived stem cells (ASCs) may accelerate wound healing are summarized. Finally, clinical studies applying ASCs for wound healing and the associated limitations are reviewed. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSBlueRock Therapeutics Strengthens Collaboration with the McEwen Stem Cell Institute BlueRock Therapeutics, LP announced the strengthening of its ongoing strategic collaboration with the McEwen Stem Cell Institute at the University Health Network in Toronto. [BlueRock Therapeutics] Press Release CardioCell has partnered with MedStar Heart & Vascular Institute in Washington, D.C., to begin a Phase IIa study using its patented low-oxygen grown MSCs (itMSCs). The trial aims to determine whether the itMSCs improve myocardial function in patients with severe heart failure-severe enough to require the implantation of a LVAD. [CardioCell] Press Release Therapeutic Solutions International, Inc. announced the signing of an agreement between TSOI and Jadi Cell LLC for licensing of the Jadi Cell universal donor adult stem cell, as covered in US Patent No.: 9,803,176 B2 for use in chronic traumatic encephalopathy, and traumatic brain injury. [Therapeutic Solutions International, Inc. (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSDespite Growing Budget, U.S. Cancer Institute Slashes Operating Budget by 5% A good year for biomedical research funding has turned sour at the National Cancer Institute (NCI) in Bethesda, Maryland, where the director is cutting operating budgets by 5% across the agency. Despite a rising overall budget, NCI’s funds are being stretched thin by various priorities and a ballooning number of funding applications, explains NCI Director Norman Sharpless. [ScienceInsider] Editorial Europe’s AI Researchers Launch Professional Body over Fears of Falling Behind Some of Europe’s top machine-learning researchers have founded an organization to strengthen capacity in artificial intelligence (AI) technology on the continent. [Nature News] Editorial Lawsuit Alleges NIH, FDA Let Clinical Trial Sponsors Off the Hook A former top official at the Food and Drug Administration and a longtime science journalist are suing the agency and the National Institutes of Health, saying they let clinical trial sponsors off the hook for reporting nearly a decade’s worth of important scientific data. [STAT News] Editorial
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EVENTSNEW 5th Annual Perinatal Stem Cell Society Congress NEW 3rd International Conference on Stem Cells NEW Tissue Engineering & Regenerative Medicine International Society – AP Chapter and the 7th Asian Biomaterials Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Assistant Professor Positions – Department of Cardiology (Boston Children’s Hospital) Postdoctoral Position – Stem Cell Genomics & Tissue Engineering (Friedrich Miescher Laboratory) PhD Positions – Bone Healing & Soft-Tissue Inflammation (University of Gothenburg) Assistant Professor – Department of Biological Sciences (Rutgers University Newark) Tenure Track Assistant Professor – Center for Regenerative Medicine (Massachusetts General Hospital) Postdoctoral Position – Regenerative Medicine, Stem Cells & Bioengineering (Igenomix Foundation) Associate Professor/Professor – Regenerative Medicine or Stem Cell Biology (University of Toronto) Postdoctoral Researcher – Tissue Engineering & Organs on a Chip (OHSU School of Dentistry) Faculty Position – Department of Biochemistry & Molecular Biology (Mayo Clinic) Postdoctoral Fellowships – Nanomedicine & Biomedical Engineering (University of British Columbia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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