Mesenchymal Cell News Volume 10.50 | Dec 18 2018

TOP STORY

Pressure-Induced Mesenchymal Stem Cell Osteogenesis Is Dependent on Intermediate Filament Remodeling

Scientists demonstrated that cyclic hydrostatic pressure is a potent mediator of cytoskeletal reorganization and increases in osteogenic responses in MSCs. They demonstrated that the intermediate filament (IF) network undergoes breakdown and reorganization with centripetal translocation of IF bundles toward the perinuclear region. [FASEB J] Full Article

(Ranked by impact factor of the journal)

IN VITRO

F-Doped TiO₂ Microporous Coating on Titanium with Enhanced Antibacterial and Osteogenic Activities

Both the in vitro and in vivo results indicated that titanium (Ti) O₂/calcium-phosphate coatings (TiCP) and TiCP-fluorine (F)1 were of much higher osteogenic activity compared with Ti but lacking of bacterial resistance, whereas TiCP with high F addition exhibited both dramatically improved bacterial resistance and osteogenesis. [Sci Rep] Full Article

Isolation and Characterization of Turkey Bone Marrow-Derived Mesenchymal Stem Cells

The multipotency of turkey bone marrow-derived mesenchymal stem cells was determined by differentiating cells into osteogenic, adipogenic, chondrogenic and tenogenic lineages. There was upregulated gene expression of tenogenic markers, including mohawk, tenomodulin and EGR1 as well as increased collagen synthesis in BMP12 induced cells. [J Orthop Res] Abstract

Effects of the Potassium-Sparing Diuretic Amiloride on Chemotherapy Response in Canine Osteosarcoma Cells

Amiloride strongly synergized with doxorubicin in combination treatment and exhibited additive or antagonistic effects with carboplatin in canine osteosarcoma cells. [J Vet Intern Med] Full Article

IN VIVO

Gender-Independent Efficacy of Mesenchymal Stem Cell Therapy in Sex Hormone-Deficient Bone Loss via Immunosuppression and Resident Stem Cell Recovery

Using the gonadectomy (GNX) model, investigators confirmed that the osteoporotic phenotypes were substantially consistent between female and male mice. Systemic MSC transplantation not only rescued trabecular bone loss in GNX mice but also restored cortical bone mass and bone quality. No differences were detected between the genders. [Exp Mol Med] Full Article

Effects of Different Doses of Mesenchymal Stem Cells on Functional Recovery after Compressive Spinal-Cord Injury in Mice

This study compared the efficacy of three different doses of mesenchymal stem cells administered by intraperitoneal injection as a therapeutic strategy for compressive SCI. Researchers used adult female C57BL/6 mice that underwent laminectomy at the T9 level, followed by spinal-cord compression for 1 minute with a 30 g vascular clip. [Neuroscience] Abstract

Anti-Depressive Effect of Shuangxinfang on Rats with Acute Myocardial Infarction: Promoting Bone Marrow Mesenchymal Stem Cells Mobilization and Alleviating Inflammatory Response

Scientists explored shuangxinfang’s (Psycho-cardiology Formula, PCF) psycho-cardiology effects in rats with acute myocardial infarction and explored its potential mechanism. Results showed PCF inhibited inflammation caused by injured myocardium, improved heart function and depression developed from myocardial infarction, and these might partly attribute to the higher bone marrow mesenchymal stem cells mobilization efficiency promoted by PCF. [Biomed Pharmacother] Full Article

Controllable Fabrication of Hydroxybutyl Chitosan/Oxidized Chondroitin Sulfate Hydrogels by 3D Bioprinting Technique for Cartilage Tissue Engineering

With the aid of three-dimensional bioprinted sacrificial molds, hydroxybutyl chitosan/oxidized chondroitin sulfate (HBC/OCS) hydrogel with various structures were obtained. After the material constituent optimization process, an injectable hydrogel with a uniform porous structure of 100 μm average pore size was developed to form macroporous hydrogel. In vitro and in vivo biocompatibility of optimized HBC/OCS hydrogel were also assessed. [Biomed Mater] Abstract

Modification of the Bone Marrow MSC Population in a Xenograft Model of Early Multiple Myeloma

Researchers evaluated the modification of the MSC population in the bone niche in an in vivo model of multiple myeloma (MM). They showed that before an observable engraftment of MM in the bone niche, the proportion of MSC population was significantly decreased, while a significant increase in adipocyte related genes such as PPARγ and CEBPα expression appeared, with no difference in osteogenic differentiation. [Biochem Biophys Res Commun] Abstract

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Mesenchymal Stem Cell-Based Drug Delivery Strategy: From Cells to Biomimetic

The authors provide a comprehensive overview of the utility of mesenchymal stem cells (MSCs) in drug and gene delivery as well as MSC membrane coated nanoparticles for therapy and drug delivery, aiming to figure out the significant room for development and highlight the potential future directions. [J Control Release] Abstract | Graphical Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

NHMRC to Fund Major Phase II Clinical Trial of Cynata’s Cymerus™ MSCs in Patients with Osteoarthritis

Cynata Therapeutics Limited announced that the Australian National Health and Medical Research Council has approved a grant to fund a Phase II clinical trial to evaluate Cynata’s Cymerus™ mesenchymal stem cells as a treatment for osteoarthritis. [Cynata Therapeutics (GlobeNewswire, Inc.)] Press Release

Prellis Biologics, Inc. Announces Vascular Tissue Blanks™, a Series of Ready to Use, Pre-Vascularized Tissue Scaffolds for Complex 3D Cell and Tissue Cultures and Transplantation

Prellis Biologics has launched the first ever line of pre-vascularized 3D tissue scaffolds. The scaffolds are biocompatible and can be used by researchers to grow any cell type in 3D formats 1000x larger than 3D spheroids. [Prellis Biologics (Business Wire, Inc.)] Press Release

Tenured Biology Professor Sacked for Research Misconduct

The University of Illinois at Urbana-Champaign has fired former tenured biology professor, Fei Wang, after an investigation revealed he had falsified data on grant applications, The News-Gazette, reports. At a meeting on Friday (December 14), the university’s board of trustees made the final decision, effective immediately, to fire Wang. [The Scientist] Editorial

What a Partial US-Government Shutdown Would Mean for Science

The clock is ticking for US lawmakers, who have fewer than four days — as of 18 December — to pass a new budget for many government agencies, or they will trigger a partial government shutdown. Nature explains why politicians are struggling to reach a deal, what is at stake for science and whether a crisis can be avoided. [Nature News] Editorial

NEW 11^th World Biomaterials Congress
May 19-24, 2020
Glasgow, Scotland

Visit our events page to see a complete list of events in the community.

NEW Assistant Professor – Cancer Biology (University of Pennsylvania Perelman School of Medicine)

Professor/Associate Professor/Assistant Professor Positions – Stem Cell Biology (IRCMS Kumamoto University)

Assistant Professor Positions – Department of Cardiology (Boston Children’s Hospital)

Assistant Professor – Department of Biological Sciences (Rutgers University Newark)

Tenure Track Assistant Professor – Center for Regenerative Medicine (Massachusetts General Hospital)

Postdoctoral Position – Regenerative Medicine, Stem Cells & Bioengineering (Igenomix Foundation)

Associate Professor/Professor – Regenerative Medicine or Stem Cell Biology (University of Toronto)

Postdoctoral Researcher – Tissue Engineering & Organs on a Chip (OHSU School of Dentistry)

Assistant/Associate Professors – Center for Stem Cell & Organoid Medicine (Cincinnati Children’s Hospital Medical Center)

Postdoctoral Fellowships – Nanomedicine & Biomedical Engineering (University of British Columbia)

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