Mesenchymal Cell News Volume 11.01 | Jan 15 2019

TOP STORY

Autocrine Regulation of Mesenchymal Progenitor Cell Fates Orchestrates Tooth Eruption

Investigators showed that the parathyroid hormone-related peptide and the PTH/PTHrP receptor autocrine signal maintains physiological cell fates of dental follicle mesenchymal progenitor cells to establish the functional periodontal attachment apparatus and orchestrates tooth eruption. [Proc Natl Acad Sci USA] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Extracellular Vesicles Mediate Improved Functional Outcomes in Engineered Cartilage Produced from MSC/Chondrocyte Cocultures

Researchers demonstrated that juvenile chondrocytes in coculture with adult mesenchymal stem cells (MSCs) promoted functional differentiation and improved matrix production. They further demonstrated that close proximity between the two cell types is a prerequisite for this response and that the outcome of this interaction improves viability, chondrogenesis, matrix formation, and homeostasis in the recipient MSCs. [Proc Natl Acad Sci USA] Abstract

Cell Number in Mesenchymal Stem Cell Aggregates Dictates Cell Stiffness and Chondrogenesis

Progression of chondrogenic differentiation in aggregates was assessed over three weeks in presence and absence of transforming growth factor-beta 1. Mechanical properties of the cells were characterized using high-throughput real-time deformability cytometry, and gene expression was analyzed using Affymetrix gene array. [Stem Cell Res Ther] Full Article | Press Release

GMP-Compatible and Xeno-Free Cultivation of Mesenchymal Progenitors Derived from Human-Induced Pluripotent Stem Cells

Scientists investigated the effects of expanding mesodermal progenitor cells derived from two human-induced pluripotent stem cell lines in xeno-free medium supplemented with human platelet lysates and in a commercial high-performance Good Manufacturing Practice-compatible medium. [Stem Cell Res Ther] Full Article | Graphical Abstract | Press Release

In Vitro Interaction of Human Wharton’s Jelly Mesenchymal Stem Cells with Biomimetic 3-D Scaffold

Three-week culture of wharton’s jelly mesenchymal stem cells (hWJ-MSCs) on scaffolds, immersed in osteogenic medium, rendered the microenvironment in favor of wharton’s jelly mesenchymal stem cells differentiation into osteoblast cells and extracellular matrix secretion. [J Biomed Mater Res A] Abstract

Differentiation of Human Mesenchymal Stem Cells (MSC) to Dopaminergic Neurons: A Comparison between Wharton’s Jelly and Olfactory Mucosa as Sources of MSCs

The authors assessment of the functionality of differentiated cells and their ability to synthesize dopamine measured by HPLC revealed that olfactory ectomesenchymal stem cells-derived dopaminergic cells released almost the same amount of dopamine as that secreted by wharton’s jelly-derived mesenchymal stem cells-derived cells. Thus it showed the difference in their functionality to be negligible. [J Chem Neuroanat] Abstract | Graphical Abstract

IN VIVO

Liver Macrophage Depletion Ameliorates the Effect of Mesenchymal Stem Cell Transplantation in a Murine Model of Injured Liver

Superparamagnetic iron oxide-labeled human mesenchymal stem cells were injected intravenously into mice treated with carbon tetrachloride and subjected to hepatic macrophage-depletion. Liver tissues were collected at different intervals post transplantation for subsequent histopathological, morphometric, immunohistochemical, gene expression and ultrastructural studies. [Sci Rep] Full Article

H19 and Foxc2 Synergistically Promotes Osteogenic Differentiation of BMSCs via Wnt-β-Catenin Pathway

Researchers found that H19 expression was reduced in the serum of patients with postmenopausal osteoporosis and bone marrow mesenchymal stem cells (BMSCs) of ovariectomized mice, and overexpression of H19 promoted osteogenic differentiation of BMSCs. [J Cell Physiol] Abstract

Umbilical Cord Mesenchymal Stem Cells and Umbilical Cord Blood Mononuclear Cells Improve Neonatal Rat Memory after Hypoxia-Ischemia

Scientists showed that transplantation of human umbilical cord mesenchymal stem cells or cord blood mononuclear cells after hypoxic-ischemic encephalopathy reduced astrogliosis, prevented neuronal loss in the striatum, and markedly improved functional brain outcomes after a 28-day recovery period. [Behav Brain Res] Abstract

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Concise Review: The Challenges and Opportunities of Employing Mesenchymal Stromal Cells in the Treatment of Acute Pancreatitis

The authors outline the challenges inherent in the small animal models of acute pancreatitis. They also point to specific benefits afforded by the adoption of larger animal models. [Biotechnol Adv] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

BrainStorm to Present NurOwn^® Phase III Study Update

BrainStorm Cell Therapeutics Inc. announced that Ralph Kern MD, MHSc, Chief Operating Officer and Chief Medical Officer, will provide a clinical update for the ongoing Phase III pivotal trial of NurOwn^® in ALS patients. [Press release from BrainStorm Cell Therapeutics Inc. discussing research to be presented at 9^th Annual California ALS Research Summit, Irvine] Press Release

NYSCF Inks Strategic Partnership with Ngene Therapeutics

The New York Stem Cell Foundation (NYSCF) Research Institute announced a partnership with Ngene Therapeutics Inc. to develop new disease treatments that leverage human stem cell research and novel gene editing techniques. [The New York Stem Cell Foundation] Press Release

Open-Access Row Prompts Editorial Board of Elsevier Journal to Resign

The editorial board of an influential scientometrics journal — the Journal of Informetrics — has resigned in protest over the open-access policies of its publisher, Elsevier, and launched a competing publication. [Nature News] Editorial

If the Shutdown Drags on at FDA, It Will Put Anticipated New Treatments in Jeopardy

The government shutdown could soon jeopardize highly anticipated new drugs from Janssen, Sanofi and Novartis for depression, diabetes and multiple sclerosis, as well as a host of other potential new therapies, according to a STAT analysis of upcoming regulatory decision dates. [STAT News] Editorial

NEW Gordon Research Conference: Tissue Repair & Regeneration
June 9-14, 2019
New London, United States

Visit our events page to see a complete list of events in the community.

NEW PhD Positions – Cancer Biology (Institut Curie)

Postdoctoral Training Fellow – Cancer Genomics (The Francis Crick Institute)

Postdoctoral Fellow – Lung Biology/Lung Immunology (Royal College of Surgeons in Ireland)

Assistant Professor – Sarcoma & Skeletal-Related Malignancies (UC Davis School of Medicine)

Postdoctoral Fellow – Stem Cell Biology (City of Hope)

Research Fellow – Stem Cell Biology (Brigham & Women’s Hospital – Harvard Medical School)

Post Doctoral Fellow – Stem Cell Biology (Technion – Israel Institute of Technology)

Assistant Professor – Cancer Biology (University of Pennsylvania Perelman School of Medicine)

Assistant Professor Positions – Department of Cardiology (Boston Children’s Hospital)

Assistant Professor – Department of Biological Sciences (Rutgers University Newark)

Postdoctoral Position – Regenerative Medicine, Stem Cells & Bioengineering (Igenomix Foundation)

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