Mesenchymal Cell News 11.05 February 12, 2019 | |
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TOP STORYScientists demonstrated that bone marrow (BM)-derived MSCs (BM-MSCs) expressed higher levels of periostin (POSTN) when co-cultured with B cell acute lymphoblastic leukemia (B-ALL) cells in vitro and in vivo. POSTN deficiency in BM-MSCs significantly decreased CCL2 expression in co-cultured B-ALL cells in vitro and in vivo. [Cell Rep] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROOverexpression of peroxisome proliferator-activated receptor γ coactivator-1β-OT1 (PGC1β-OT1) in progenitor cells inhibited adipogenic differentiation, whereas silencing of endogenous PGC1β-OT1 induced adipogenic differentiation. By contrast, overexpression of PGC1β-OT1 in progenitor cells stimulated, whereas silencing of PGC1β-OT1 inhibited osteogenic differentiation. [Cell Death Differ] Abstract Transforming growth factor β1 (TGF-β1) secretion by MSCs activated SMAD2/3 through TGF-β receptors and induced long non-coding RNA (lncRNA) MACC1-AS1 expression in gastric cancer cells, which promoted fatty acid oxidation (FAO)-dependent stemness and chemoresistance through antagonizing miR-145-5p. Pharmacologic inhibition of FAO with etomoxir attenuated MSC-induced FOLFOX regiment resistance in vivo. [Oncogene] Full Article KIAA1199 Is a Secreted Molecule That Enhances Osteoblastic Stem Cell Migration and Recruitment KIAA1199 deficient human MSCs exhibited significant changes in cell size, cell length, ratio of cell width to length and cell roundness, together with reduction of polymerization actin and changes in phos-cofflin1, phos-LIM domain kinase 1 and destrin, key factors regulating actin cytoskeletal dynamics and cell motility. [Cell Death Dis] Full Article In order to mimic the microenvironment in spinal cord injury that neuronal cells or transplanted bone marrow derived MSCs (BMSCs) suffer in vivo, PC12 cell conditioned medium and PC12 cell’s exosomes collected from H2O2-treated PC12 cell’s culture medium were cultured with BMSCs under oxidative stress in vitro. [Cell Death Dis] Full Article Placenta MSCs (pMSCs) were cultured with IL-2-activated and non-activated natural killer (NK) cells. NK cell expression of receptors mediating their cytolytic activity against pMSCs, and the mechanisms underlying this effect on pMSCs, were also investigated. [Stem Cell Res Ther] Full Article IN VIVOTumorigenicity of A549 and H23 cells with or without MSC-secreted extracellular vesicle co-injection was assayed on immunocompromised mice. The xenograft tumor was examined for cell proliferation, angiogenesis, apoptosis and intra-tumoral M1/M2 macrophage polarization. [J Exp Clin Cancer Res] Full Article Investigators designed and explored the ability of bone marrow derived MSC-loaded elastic poly(glycerol sebacate) (PGS) scaffold to prevent intrauterine adhesion and compared the effect of PGS with poly(lactic-co-glycolic acid) and collagen scaffolds in resumption of damaged rat uteruses. [Adv Healthc Mater] Abstract Soluble TRAIL Armed Human MSC as Gene Therapy for Pancreatic Cancer Adipose MSCs (AD-MSC) were armed to constantly release a soluble trimeric and multimeric variant of the known anti-cancer TNF-related apoptosis-inducing ligand (sTRAIL). sTRAIL released by AD-MSC relocated into the tumor stroma was able to significantly counteract tumor growth in vivo with a significant reduction in tumor size, in cytokeratin-7+ cells and by an anti-angiogenic effect. [Sci Rep] Full Article Rats calcaneal tendons were divided into five groups: normal, transected (T), transected and adipose-derived MSCs (ASCs) or low-level laser (LLL), or with ASCs and LLL. In comparison with T, LLL also up-regulated Gdf5 gene expression, ASCs up-regulated the expression of Tnmd, and the association of LLL and ASCs down-regulated the expression of Scx. [Cell Prolif] Full Article Researchers investigated whether intra bladder wall autologous bone marrow MSC transplantation, as a minimally invasive method, could improve bladder dysfunctions after a chronic phase of hemi- and complete-transection spinal cord injury in a female rat model. [Life Sci] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSDifferent MSC products display varying levels of highly procoagulant tissue factor and may adversely trigger an instant blood-mediated inflammatory reaction. Suitable strategies for assessing and controlling hemocompatibility and optimized cell delivery are crucial for the development of safer and more effective MSC therapies. [Trends Mol Med] Abstract MSCs exhibit immunosuppressive properties and are being tested in clinical trials for their safety and efficacy in treating many immune-mediated disorders. Graft-versus-host disease is one of the first areas in which MSCs were clinically applied, and it is important that the accumulating evidence is systematically reviewed to assess whether their use is favored. [Cochrane Database Syst Rev] Full Article Exploring the Roles of MSCs in Infections: Focus on Bacterial Diseases The authors critically explore MSCs’ role in E. coli, S. aureus, and polymicrobial infections. Summarizing from various studies, in vitro and in vivo results support the mechanistic involvement of MSCs and their derivatives in fighting infection and in contributing to microbial spreading. [J Mol Med] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSCytonus Therapeutics Inc. announced that it has developed Cargocytesâ„¢ a first-of-its-kind, controllable, cell-based platform technology for delivery of biologics. [Cytonus Therapeutics Inc. (Business Wire, Inc.)] Press Release VA Pushing Medical Research and Inventions to Private Sector The US Department of Veterans Affairs (VA) announced a new effort to improve public health by pushing its research and inventions into commercial markets. [U.S. Department of Veterans Affairs (TechLink)] Press Release | |
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POLICY NEWSEurope’s Next €1-Billion Science Projects: Six Teams Make It to Final Round The European Commission has selected six research projects — in areas from health and energy to artificial intelligence and cultural heritage — to compete to become one of its next billion-euro ‘flagship’ science initiatives, Nature has learned. [Nature News] Editorial Ukraine’s Science Revolution Stumbles Five Years On Ukraine’s science system is in a precarious state, despite promised improvements in the wake of a revolution five years ago that aligned the country with the European Union. [Nature News] Editorial Violent Drug Cartels Stifle Mexican Science Abandoned projects and delayed research have become common problems as security issues crop up across the country. [Nature News] Editorial
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EVENTSNEW EMBO Workshop: Bridging Cell & Tissue Mechanics to Fate Specification in Development Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESResearch Scientist – Stem Cell Biology (MD Anderson Cancer Center) Stem Cell Production Officer – Clinical Grade MSCs (University of London – Royal Veterinary College) Postdoctoral Fellow – MSC Research (University of Illinois at Chicago College of Medicine) PhD Positions – Cancer Biology (Institut Curie) Postdoctoral Training Fellow – Cancer Genomics (The Francis Crick Institute) Assistant Professor – Sarcoma & Skeletal-Related Malignancies (UC Davis School of Medicine) Postdoctoral Fellow – Stem Cell Biology (City of Hope) Research Fellow – Stem Cell Biology (Brigham & Women’s Hospital – Harvard Medical School) Post Doctoral Fellow – Stem Cell Biology (Technion – Israel Institute of Technology) Assistant Professor – Department of Biological Sciences (Rutgers University Newark) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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