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Pulmonary Cell News| Mesenchymal Cell News 11.32 August 20, 2019 | |
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TOP STORYThe transcriptomic signature of “brite/beige” thermogenic adipocytes revealed mechanisms for iron accumulation and protection from oxidative stress, necessary for mitochondrial biogenesis and respiration upon activation. This signature was enriched in human supraclavicular adipose tissue, confirming that these cells comprised thermogenic depots in vivo, and explain previous findings of a rate-limiting role of iron in adipose tissue browning. [Proc Natl Acad Sci USA] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITRODouble Network Polyurethane-Gelatin Hydrogel with Tunable Modulus for High Resolution 3D Bioprinting MSCs printed with the polyurethane (PU)-gelatin hydrogel through the 80 μm nozzle showed good viability, high mobility, and ~200% proliferation ratio in ten days. Furthermore, the MSC-laden PU-gelatin constructs containing small molecular drug Y27632 underwent chondrogenesis in ten days. [ACS Appl Mater Interfaces] Abstract Researchers investigated the effect of human bone-marrow derived MSCs (BMSCs)-derived exosomal miR-143 on prostate cancer. During the co-culture experiments, they disrupted exosome secretion by the inhibitor GW4869 and overexpressed exosomal miR-143 using miR-143 plasmid. [Mol Ther Nucleic Acids] Abstract | Full Article Investigators report a rapid and efficient protocol based on defined culture conditions capable of differentiating adult adipose-derived stem cells to scalable amounts of proliferative melanocyte precursors (PreMel) within 30 days. PreMel were characterized in vitro through qPCR, Western blot, flow cytometry, biochemical assays, and in vivo assays in immunocompromised mice. [Stem Cell Res Ther] Full Article Primary orbital fibroblasts were exposed to differentiation medium for ten days. After being co-cultured with human placenta MSCs, the characteristics of orbital fibroblast were determined by Oil Red O stain and real-time PCR. [Stem Cell Res Ther] Full Article Researchers describe an isolation method, characterized a population, and investigated its potential for cell banking and thus suitability as a potential product for cell grafting therapies. Results showed human fetal-derived dermal fibroblasts and a bone marrow-derived MSCs line shared identification markers and in vitro multilineage differentiation potential into osteogenic, chondrogenic, and adipogenic lineages. [Cell Transplant] Full Article Scientists isolated human adipose-derived stem cells (hASCs) and investigated the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) and extracellular Ca2+ concentration on the osteogenic differentiation of hASCs. rhBMP-2 promoted calcium deposition in hASCs and stimulated the mRNA expressions of six proteins known to be involved in the osteogenic differentiation of hASCs: Runx2, osterix, alkaline phosphatase, osteonectin, bone sialoprotein and osteocalcin. [Cell Calcium] Abstract | Graphical Abstract Human MSCs laden non-printed and bioprinted composite scaffolds were fabricated. Bioprinting did not affect cell viability, but alginate concentration had a significant influence on cell viability and cell morphology. [Biomed Mater] Abstract IN VIVOAsymmetrical Methyltransferase PRMT3 Regulates Human Mesenchymal Stem Cell Osteogenesis via miR-3648 Scientists aimed to elucidate the function of protein arginine methyltransferase (PRMT)3, a type-I PRMT that catalyzed the formation of ω-mono- or asymmetric dimethyl arginine, in MSCs osteogenesis. They found that PRMT3 promoted MSCs osteogenic commitment and bone remodeling. [Cell Death Dis] Full Article The authors used a rat model to test the osteogenic properties of bone marrow-derived MSC-seeded bone microparticles compared to acellular bone microparticles alone. Rats were euthanized at four and eight weeks, and results analyzed using micro-CT imaging, histology, histomorphometry and immunohistology. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSStem Cell-Based Bone and Dental Regeneration: A View of Microenvironmental Modulation Investigators summarize current knowledge regarding the tactics of MSC-based bone and dental regeneration and the decisive role of the micro-environment, emphasizing the therapeutic potential of micro-environment-targeting strategies in bone and dental regenerative medicine. [Int J Oral Sci] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSCLR 131 Advances to Second Malignant Brain Tumor Cohort of Ongoing Pediatric Phase I Study Cellectar Biosciences, Inc. announced it has successfully completed the first cohort of malignant brain tumor patients in its ongoing Phase I trial of CLR 131 in children and adolescents with select solid tumors, lymphoma, and malignant brain tumors, including relapsed or refractory neuroblastoma, rhabdomyosarcoma, Ewing’s sarcoma, and osteosarcoma. [Cellectar Biosciences, Inc.] Press Release RenovaCare, Inc. announced the issuance of a new patent allowing the company’s novel medical device to now spray all varieties of tissues and cells, thus opening the door for its potential application in the regeneration of tissues and organs, beyond skin. [RenovaCare, Inc.] Press Release Steadman Philippon Research Institute Awarded First NIH Award Steadman Philippon Research Institute has received a research award from the National Institutes of Health (NIH) to investigate bone abnormalities and healing defects in connection with Duchenne muscular dystrophy. [Steadman Philippon Research Institute (Globe Newswire, Inc.)] Press Release | |
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POLICY NEWSBrazil’s Budget Cuts Threaten More Than 80,000 Science Scholarships Brazil’s main science-funding agency will have to suspend more than 80,000 scholarships to postdoctoral researchers and graduate and undergraduate students starting in September unless it receives additional cash from the government. [Nature News] Editorial The Push to Replace Journal Supplements with Repositories Broken links, clunky formats, and outdated platforms have both authors and publishers turning to alternative solutions. [The Scientist] Editorial
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EVENTSNEW Hypoxia: Molecules, Mechanisms and Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Stem Cells (GlaxoSmithKline plc.) NEW Postdoctoral Researchers – Stem Cell Biology (Simon Fraser University) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Postdoctoral Researcher – MSCs in Accelerated Aging Treatment (MD Anderson Cancer Center) Postdcotral Research – MSC Donation (MD Anderson Cancer Center) Postdoctoral Researcher – Sarcoma and Leukemia (Cedars-Sinai Medical Center) Research Fellow – Regenerative Medicine (ROHTO Advanced Research) Postdoctoral Fellow – Mesenchymal Tumor Invasion Research (Luxembourg Institute of Health) Postdoctoral Fellow – Immunology & Respiratory Disease Research with MSCs (Boehringer Ingelheim) Development Scientist – Cell Therapy (GE) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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