Mesenchymal Cell News Volume 11.33 | Aug 27 2019

TOP STORY

Equivalent 10-Year Outcomes after Implantation of Autologous Bone Marrow-Derived Mesenchymal Stem Cells versus Autologous Chondrocyte Implantation for Chondral Defects of the Knee

72 patients who underwent either autologous chondrocyte implantation or one marrow-derived MSC implantation-matched in terms of age and lesion site- were followed up to a median of at least ten years. Patients were assessed with the 36-item Short Form Health Survey, the International Knee Documentation Committee knee evaluation form, the Lysholm Knee Score, and the Tegner Activity Scale. [Am J Sports Med] Abstract

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IN VITRO

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

A lentiviral vector designed to carry the PBX Homeobox 1 (PBX1) sequence or PBX1 short hairpin RNA sequence was used to overexpress or knock down PBX1. The roles of PBX1 in proliferation and apoptosis were investigated by flow cytometry. Real-time polymerase chain reaction was performed to evaluate pluripotent gene expression. [Stem Cell Res Ther] Full Article

The Cross-Talk between TGF-β and PDGFRα Signaling Pathways Regulates Stromal Fibro/Adipogenic Progenitors’ Fate

Researchers showed that the number of fibro/adipogenic progenitors correlated with TGF-β levels and with extracellular matrix deposition during regeneration and repair. Interestingly, the expression of PDGFRα changed dynamically in the stromal/fibroblast lineage after injury. [J Cell Sci] Abstract

Investigating How Organic Solvents Affect Tissue Culture Polystyrene Surfaces through Responses of Mesenchymal Stem Cells

Solvent-treated tissue culture polystyrene (TCPS) surfaces using water, methanol, ethanol, 2-propanol, and dimethyl sulfoxide were fabricated. Solvent treatment of TCPS surfaces was performed by spreading solvents onto the surfaces and allowing them to dry. [Macromol Biosci] Abstract

SGPL1₃₂₁ Mutation: One Main Trigger for Invasiveness of Pediatric Alveolar Rhabdomyosarcoma

Investigators demonstrated a sphingosine-1-phosphate lyase (SGPL1) overexpression and mislocalization in pediatric alveolar rhabdomyosarcoma cells. Moreover, a homozygous point mutation from A to G at position 321 in the coding sequence was obvious, which interfered with the sphingosine-1-phosphate degradation activity and correct localization in the ER-membrane. [Cancer Gene Ther] Full Article

The Influence of Parathyroid Hormone 1-34 on the Osteogenic Characteristics of Adipose- and Bone-Marrow-Derived Mesenchymal Stem Cells from Juvenile and Ovarectomized Rats

Cells were isolated from the adipose and bone marrow of juvenile, adult, and previously ovarectomized Wistar rats, and were characterized with flow cytometry, proliferation assays, osteogenic and adipogenic differentiation, and migration to stromal cell-derived factor-1. Experiments were repeated with and without intermittent human parathyroid hormone 1-34. [Bone Joint Res] Full Article

NFIC Promotes the Vitality and Osteogenic Differentiation of Rat Dental Follicle Cells

Dental follicle cells (DFCs) were isolated from dental follicles in the first molars of neonatal rats. DFCs expressed mesenchymal stromal cell markers CD29, CD44 and CD90 and had capabilities for self-renewal and multipotent differentiation. [J Mol Histol] Full Article

IN VIVO

Mesenchymal Stem Cells Restore the Sperm Motility from Testicular Torsion-Detorsion Injury by Regulation of Glucose Metabolism in Sperm

16 male Sprague-Dawley rats six-eight weeks old received left testis 720° torsion for three hours followed by detorsion with or without MSCs. Right inguinal skin incision without testicular torsion served as control. MSCs with 3×10₄ cells were locally injected into left testis 30 min before detorsion. [Stem Cell Res Ther] Full Article

Bone Sarcoma Patient-Derived Xenografts Are Faithful and Stable Preclinical Models for Molecular and Therapeutic Investigations

A panel of patient-derived xenografts was established by implantation of fresh, surgically resected osteosarcoma (OS) and Ewing sarcoma (EW) in NSG mice. Engraftment was obtained in 22 of 61 OS and 7 of 29 EW. [Sci Rep] Full Article

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Mesenchymal Stem Cells in Allergic Diseases: Current Status

The authors focus on the discoveries and biological mechanisms of MSCs as a therapeutic tool in allergic diseases. They discuss the challenges of conducting MSC studies as well as future directions. [Allergol Int] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

FDA Provides Guidance on Clinical Pathway to Marketing Application for Revascor in End-Stage Heart Failure Patients with an LVA

Mesoblast Limited announced positive outcomes from its recent meeting with the FDA on the pathway for marketing authorization of its allogeneic cell therapy product candidate Revascor in end-stage heart failure patients implanted with a left ventricular assist device. [Mesoblast Limited] Press Release

Baylor Awarded CPRIT Grants to Support Cancer Research

Baylor College of Medicine has been awarded more than $17.4 million by the Cancer Prevention & Research Institute of Texas (CPRIT) to support new cancer research and programs, core facilities and recruitment of new faculty. More than 70 grants were awarded to institutions across Texas, totaling close to $136 million to advance the fight against cancer, including nine grants to Baylor College of Medicine. [Baylor College of Medicine] Press Release

Memo to Italy’s President: Your Researchers Need You

Italy’s coalition government ended abruptly, when the nationalist Lega party of deputy prime minister Matteo Salvini announced that it was walking away from its turbulent coalition with the anti-establishment M5S party, known as the Five Star Movement. The collapse is of great concern: a much-delayed funding increase is now on hold, and the political uncertainty adds further threat. [Nature News] Editorial

NSF Graduate Fellowships Disproportionately Go to Students at a Few Top Schools

As this year’s eligible students begin to labor over their applications, it’s worth asking why certain schools come away with dozens of winners each year—and what that means about the academy at large. [ScienceInsider] Editorial

DEA Again Promises to Improve Access to Marijuana for Research

Drug Enforcement Administration (DEA) announced plans to create new regulations to expand scientific and medical research on marijuana in the US. Scientists hope the proposal will allow additional growers to enter the supply chain and hopefully bump up the quality of the material. [The Scientist] Editorial

‘Paralysed by Anxiety’: Researchers Speak about Life in Troubled Ancient-DNA Lab

The University of Adelaide has suspended the leader and founder of its premier ancient-DNA center, Alan Cooper, following an investigation into the ‘culture’ at the Australian center. The university has not given a reason for its decision, but current and former co-workers of Cooper – an award-winning evolutionary biologist who specializes in human migration – have told Nature that he bullied them or that they watched him bully others. [Nature] Editorial

NEW 7^th World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases (BMJD)
October 17-19, 2019
Taipei, Taiwan, China

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Cell Cycles in Stem Cells (University of Vaclifornia Santa Cruz)

NEW Postdoctoral Researcher – Development and Stem Cell Biology (California Institute of Technology)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Stem Cells (GlaxoSmithKline plc.)

Postdoctoral Researchers – Stem Cell Biology (Simon Fraser University)

Postdoctoral Researcher – MSCs in Accelerated Aging Treatment (MD Anderson Cancer Center)

Postdcotral Research – MSC Donation (MD Anderson Cancer Center)

Postdoctoral Researcher – Sarcoma and Leukemia (Cedars-Sinai Medical Center)

Research Fellow – Regenerative Medicine (ROHTO Advanced Research)

Postdoctoral Fellow – Mesenchymal Tumor Invasion Research (Luxembourg Institute of Health)

Postdoctoral Fellow – Immunology & Respiratory Disease Research with MSCs (Boehringer Ingelheim)

Development Scientist – Cell Therapy (GE)

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