Mesenchymal Cell News 11.38 October 1, 2019 | |
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TOP STORYIn Situ Tissue Engineering of Tendon-to-Bone Interface by Endogenous Stem/Progenitor Cells Investigators implemented micro-precise spatiotemporal delivery of growth factors in 3D-printed scaffolds for integrative regeneration of a fibrocartilaginous tendon-to-bone interface. Sustained and spatially controlled release of tenogenic, chondrogenic, and osteogenic growth factors was achieved using microsphere-based delivery carriers embedded in thin membrane-like scaffolds. [Biofabrication] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROThe authors investigated the crosstalk between MSCs and myeloma cells in the pro-inflammatory microenvironment promoting immune evasion and tumor growth. MSCs were collected from patients with diagnosis of MGUS, smoldering myeloma, multiple myeloma at diagnosis, relapse or refractory, and from age-matched healthy controls and cultured with peripheral blood mononucleated cells from healthy volunteer donors. [Cell Death Dis] Full Article Scientists report a novel function of phosphoenolpyruvate carboxykinase (PCK2) as a positive regulator of MSCs osteogenic differentiation. In addition to its well-known role in anabolism, they demonstrated that PCK2 regulated autophagy. PCK2 deficiency significantly suppressed autophagy, leading to the impairment of osteogenic capacity of MSCs. [Stem Cells] Abstract Design and Manufacture of 3D Cell Culture Plate for Mass Production of Cell-Spheroids Mesenchymal stem cells seeded on the newly-fabricated 3D cell culture plate aggregated to form 3D spheroids within 24 hours of incubation and well-maintained their viability. Thus, due to the capacity of mass production of the cell spheroids with a desired cell viability, the newly-fabricated plate could have great promise to prepare 3D cell spheroids for experimental as well as clinical applications. [Sci Rep] Full Article The impact of essential oil, thymol and carvacrol from Ptychotis verticillata on several bone-marrow MSC biological features were studied. These compounds showed positive effects on MSCs by preserving their morphology, sustaining their viability, promoting their proliferation, protecting them from cytotoxicity and oxidative stress. [Food Chem Toxicol] Abstract Inhibiting Expression of Cxcl9 Promotes Angiogenesis in MSCs-HUVECs Co-Culture The effect of rat bone-marrow derived MSCs on angiogenic capability of human umbilical vein endothelial cells (HUVECs) in growth medium (GM) and osteogenic induction medium (OIM) was investigated. It was demonstrated that cells co-cultured in OIM showed high efficiency in osteogenesis but failed to form capillary-like structure while the results of co-culture in GM were the opposite. [Arch Biochem Biophys] Abstract The authors assessed the release of cytokines from umbilical cord blood (UCB)-MSCs cultured with platelet-rich plasma (PRP) and observed changes in the expression of angiogenic factors. The angiogenic paracrine factors from UCB‐MSCs cultured with PRP was assessed in human umbilical vein endothelial cells (HUVECs). To assess therapeutic efficacy, UCB-MSCs and PRP were topically implanted into a combined radiation and wound injury mouse model. [Exp Dermatol] Abstract IN VIVOResearchers explored the regenerative effects of induced pluripotent stem cell (iPSC)-MSCs and the mechanisms by which iPSC-MSCs promoted mucosal healing via tumor necrosis factor-α-stimulated gene 6 in mouse models of inflammatory bowel disease. Human iPSCs were induced to differentiate into MSCs following a clinically compliant protocol. [Cell Death Dis] Full Article Impact of Mesenchymal Stromal Cell Delivery through Cardiopulmonary Bypass on Postnatal Neurogenesis Two-week-old piglets were randomly assigned to one of three groups: control, deep hypothermic circulatory-arrest, and circulatory-arrest followed by MSC administration. MSCs were delivered through cardiopulmonary bypass (CPB) during the rewarming period. Neural stem/progenitors, proliferating cells and neuroblasts were identified using immunohistochemistry at three hours after CPB. [Ann Thorac Surg] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSMolecular Determinants of Mesenchymal Cell Activation in Fibroproliferative Diseases The authors focus on the biology of MSCs and the molecular mechanisms that regulate their pertinent functions. They discuss key pro-fibrotic mediators, signaling pathways, and transcription factors that dictate their activation and persistence. [Cell Mol Life Sci] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSSalarius Pharmaceuticals, Inc. announced that the Safety Review Committees overseeing the Phase I/II clinical study of Seclidemstat in Ewing sarcoma and the Phase I study of Seclidemstat in patients with advanced solid tumors have approved the advancement of each study to the fourth level dosing cohort. [Salarius Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Press Release Yale Scientists Win NIH Awards for Pioneering Work The Yale School of Medicine’s Valentina Greco and Marina R. Picciotto are among the 11 recipients of the National Institutes of Health’s (NIH) Pioneer Award, which recognizes scientists who have a history of creative research and who show promise in originating ‘pioneering approaches to major challenges.’ Greco and Picciotto will receive $3.5 million dollars of funding over the course of five years. [Yale University] Press Release | |
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POLICY NEWSIndia Pushes for Alternatives to Animals in Biomedical Research India has become the latest nation to explore using emerging technologies such as organs-on-a-chip to replace animals in research. Earlier this month, the national regulator for biomedical research recommended fast-tracking investments in technologies that can replace animals. [Nature News] Editorial China: How Science Made a Superpower The opening ceremony of the 2008 Olympic Games in Beijing featured ancient China’s four great inventions: the compass, printing press, paper and gunpowder. The lesson on display, as taught in classrooms across the country that today publishes the most research papers, is that Chinese innovation in science and technology changed the world. [Nature News] Editorial Two-Thirds of Researchers Report ‘Pressure to Cite’ in Nature Poll An online poll answered by more than 4,300 Nature readers suggests that most researchers have felt pressured by peer reviewers to cite studies in their papers that seem unnecessary. [Nature News] Editorial
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EVENTSNEW International Conference on Hematopoietic and Mesenchymal Stem Cell Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Stem Cells (University of South Florida) NEW Postdoctoral Fellow – Stem Cells (The Francis Crick Institute) NEW Postdoctoral Fellow – Stem Cell Plasticity (Univeristy of Technology) Lecturer – Stem Cell Biology (The University of Manchester) Assistant Professors – Regenerative Medicine (Washington University in St. Louis) Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University) Postdoctoral Researcher – Development and Stem Cell Biology (California Institute of Technology) Postdoctoral Researchers – Stem Cell Biology (Simon Fraser University) Postdoctoral Researcher – MSCs in Accelerated Aging Treatment (MD Anderson Cancer Center) Postdoctoral Researcher – MSC Donation (MD Anderson Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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