Mesenchymal Cell News Volume 11.45 | Nov 19 2019

TOP STORY

Metabolic Programming Determines the Lineage-Differentiation Fate of Murine Bone Marrow Stromal Progenitor Cells

Scientists demonstrated that bone marrow stromal progenitors possessed a distinct metabolic program and were poised to respond to exogenous metabolic cues that regulated their differentiation fate. [Bone Res] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Adipose Mesenchymal Cells-Derived Extracellular Vesicles Alleviate DOCA-Salt-Induced Hypertension by Promoting Cardio-Renal Protection

The authors demonstrated that multiple administration of extracellular vesicles from adipose-derived MSCs in deoxycorticosterone acetate (DOCA)-salt hypertensive model could protect renal tissue by maintaining its filtration capacity. [Mol Ther Methods Clin Dev] Abstract | Full Article

Soft Liquid Metal Nanoparticles Achieve Reduced Crystal Nucleation and Ultrarapid Rewarming for Human Bone Marrow Stromal Cell and Blood Vessel Cryopreservation

The viability of human bone marrow-derived MSCs postcryopreservation reached 78±3%, which was threefold higher than that obtained by the conventional warming method. The cells postcryopreservation maintained their normal attachment, proliferation, surface marker expression, and intact multilineage differentiation properties. [Acta Biomater] Abstract | Graphical Abstract

Arsenic Induces Human Chondrocyte Senescence and Accelerates Rat Articular Cartilage Aging

Arsenic trioxide significantly induced senescence in human articular chondrocytes by increasing senescence-associated β-galactosidase activity and protein expression of p16, p53, and p21. [Arch Toxicol] Abstract

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties

The authors found that bone marrow-derived stromal cells from both cohorts met the standard criteria for MSC, exhibiting similar morphology, growth kinetics, gene expression profiles, and pro-angiogenic and immunosuppressive potential and the capacity to differentiate toward adipogenic, chondrogenic, and osteogenic lineages. [Front Immunol] Full Article | Graphical Abstract

Success Rates in Isolating Mesenchymal Stem Cells from Permanent and Deciduous Teeth

The overall successful isolation rate of stem cells from human exfoliated deciduous teeth and human dental pulp stem cells was 82% and 70%. [Sci Rep] Full Article

Encapsulation of Human Limbus-Derived Stromal/Mesenchymal Stem Cells for Biological Preservation and Transportation in Extreme Indian Conditions for Clinical Use

Researchers showed that alginate encapsulation was an effective method of human limbus-derived stromal/MSC preservation offering high cell viability over prolonged durations in transit at room temperature. [Sci Rep] Full Article

IN VIVO

Amelioration of Hippocampal Dysfunction by Adipose Tissue-Targeted Stem Cell Transplantation in a Mouse Model of Type 2 Diabetes

MSC transplantation normalized transgenic murine model of adipocyte insulin resistance body and epididymal fat weights and was associated with increased leptin levels, a sign of adipocyte maturation. [J Neurochem] Abstract

Hypoxic-Conditioned Medium from Adipose Tissue Mesenchymal Stem Cells Improved Neuroinflammation through Alternation of Toll Like Receptor (TLR)2 and TLR4 Expression in Model of Alzheimer’s Disease Rats

Adipose tissue MSC-conditioned medium administration decreased beta amyloid plaques and enhanced neuronal survival in Alzheimer’s disease brain rats. In addition, TLR2 and TLR4 expression decreased in treatment group. [Behav Brain Res] Abstract

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Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation

Scientists discuss the current findings in the field of MSCs derived extracellular vesicle (EV)-based therapies in immune-mediated disorders and approaches to scale EV production for clinical use. [Front Immunol] Full Article

Immune Modulation by Mesenchymal Stem Cells

MSCs could promote inflammation when the immune system is underactivated and restrain inflammation when the immune system is overactivated to avoid self-overattack. These cells express many immune suppressors to switch them from a pro-inflammatory phenotype to an anti-inflammatory phenotype, resulting in immune effector cell suppression and immune suppressor cell activation. [Cell Prolif] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

BrainStorm Cell Therapeutics Announces Research Grant Award from the National Multiple Sclerosis Society

BrainStorm Cell Therapeutics, Inc. announced that the company has received a $495,330 grant from the National Multiple Sclerosis Society, through its Fast Forward program, to advance BrainStorm’s Phase II open-label, multicenter clinical trial of repeated intrathecal administration of NurOwn^® in participants with progressive Multiple Sclerosis. [BrainStorm Cell Therapeutics, Inc.] Press Release

Aadi Bioscience Breakthrough Therapy nab-Sirolimus (ABI-009) Independent Reviewed Data Released from the AMPECT Registration Trial in Advanced PEComa

Aadi Bioscience, Inc. released its independent radiology reviewed data from the nab-sirolimus registration trial (AMPECT) for Advanced Malignant PEComa- a rare form of sarcoma for which there is no currently approved therapy. [Aadi Bioscience, Inc. (Business Wire, Inc.)] Press Release

Foreign Interference Fears Prompt Guidelines for Australian Universities

New guidelines will help Australian universities protect themselves against foreign interference, says the country’s government. The advice follows concerns that foreign groups or governments, such as the government of China, might be seeking to instigate campus activities that are against Australia’s interests. [Nature News] Editorial

Violent Clashes at Hong Kong Universities Disrupt Research

Three universities in Hong Kong have cancelled classes on campus for the rest of the term after violent clashes between police and protestors erupted in the grounds. At least another four universities have also cancelled classes — in some cases for the rest of the year — over safety concerns. [Nature News] Editorial

NEW 10^th International Meeting of the Stem Cell Network North Rhine-Westphalia
June 8-9, 2020
Aachen, Germany

Visit our events page to see a complete list of events in the community.

NEW Graduate Student Position – Stem Cell Biology (Technion – Israel Institute of Technology)

Researcher – Musculoskeletal Disorders (National University of Ireland Galway)

Postdoctoral Researcher – Embryonic and Adult Stem Cells (Yale University School of Medicine)

Faculty Position – Regenerative Medicine and Tissue Engineering (Columbia University)

Research Assistant – Stem Cells and Engineering (New York Blood Center)

Researcher – Biomaterials and Stem Cells (National University of Ireland Galway)

Postdoctroal Researcher – CRISPR/Cas9 in Tissue Regeneration (Howard Hughes Medical Institute)

Tenure-Track Positions – Biologic and Materials Sciences and Prosthodontics (University of Michigan)

Professor Positions – Biomedical Science (The Chinese University of Hong Kong)

Assistant Professor – Cell and Molecular Biology (Boston University)

Postdoctoral Researcher – Stem Cells (University of South Florida)

Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

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