Mesenchymal Cell News Volume 11.46 | Nov 26 2019

TOP STORY

Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis

Researchers sought to understand whether preadipocytes use their cilia to sense and respond to external cues to remodel white adipose tissue. Abolishing preadipocyte cilia in mice severely impairs white adipose tissue expansion. [Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

IN VITRO

Synergistic Autophagy Effect of miR-212-3p in Zoledronic Acid-Treated In Vitro and Orthotopic In Vivo Models and in Patient-Derived Osteosarcoma Cells

Scientists sought to clarify the mechanisms through which zoledronic acid (ZOL) inhibits osteosarcoma (OS) cell proliferation. ZOL treatment inhibited OS cell proliferation, viability, and colony formation. [Cancers] Full Article

Single‐Cell High Content Imaging Parameters Predict Functional Phenotype of Cultured Human Bone Marrow Stromal Stem Cells

Investigators determined the morphological characteristics of cultured primary human bone marrow (hBM)‐MSCs and examined their predictive value for hBM‐MSC functionality. BM‐MSCs were isolated from 56 donors and characterized for their proliferative and differentiation potential. [Stem Cells Transl Med] Abstract

Defective Proliferation and Osteogenic Potential with Altered Immunoregulatory Phenotype of Native Bone Marrow-Multipotential Stromal Cells in Atrophic Fracture Non-Union

Uncultured CD271^highCD45^low cells or passage-zero cultured bone marrow (BM)-MSCs were analyzed for gene expression levels, and functional assays were conducted using culture-expanded BM-MSCs. [Sci Rep] Full Article

Calcium Polyphosphate Nanoparticles Act as an Effective Inorganic Phosphate Source during Osteogenic Differentiation of Human Mesenchymal Stem Cells

The authors investigated whether polyphosphate can effectively be used as a phosphate source during the in vitro osteogenic differentiation of human bone-marrow-derived-MSCs. [Int J Mol Sci] Full Article

Crayfish Hemocyanin on Chitin Bone Substitute Scaffolds Promotes the Proliferation and Osteogenic Differentiation of Human Mesenchymal Stem Cells

Cytocompatibility, cellular adherence and proliferation of human MSCs were evaluated in terms of cell number as reflected in lactate dehydrogenase activity. Chitin, chitin-CaCO₃, and porous chitin-CaCO₃ scaffolds were all found to facilitate cell attachment. [J Biomed Mater Res A] Abstract

Chondrogenic Differentiation of Human ASCs by Stiffness Control in 3D Fibrin Hydrogel

Scientists aimed to find the optimal fibrin formulation and determine whether fibrin optimized with human adipose-derived stem cells increased the in vivo chondrogenic potential. [Biochem Biophys Res Commun] Abstract

IN VIVO

Allogeneic Mesenchymal Stem Cells for Treatment of Severe Burn Injury

The authors describe a patient with a severe burn injury whose wounds did not heal with over 18 months of conventional burn care. When treated with allogeneic MSCs, wound healing accelerated with no adverse treatment complications. [Stem Cell Res Ther] Full Article

Multiple Doses of Adipose Tissue‐Derived Mesenchymal Stromal Cells Induce Immunosuppression in Experimental Asthma

Researchers hypothesized that multiple doses of MSCs might exert better therapeutic effects by reducing lung inflammation and remodeling but might also result in immunosuppressive effects in experimental asthma. [Stem Cells Transl Med] Full Article

Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News.

Growing Evidence Supporting the Use of Mesenchymal Stem Cell Therapies in Multiple Sclerosis: A Systematic Review

The authors conducted a systematic review to inquire into the safety, tolerability, and efficacy of MSC therapies in multiple sclerosis. [Mult Scler Relat Disord] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Innovative Public-Private Partnership Led by Harvard and MIT Aims to Bolster State’s Role as a Leading Region Globally for Life Sciences

An innovative new major private-public partnership led by Harvard and MIT aims to accelerate one of the hottest and most promising areas of medical research: cell and gene therapy. [The Harvard Gazette] Press Release

Hope Biosciences Receives FDA Approval to Commence Groundbreaking Clinical Trial for Alzheimer’s

Hope Biosciences announced that FDA has approved a Phase I/II clinical trial evaluating safety and efficacy of Hope Biosciences’ autologous, adipose-derived MSCs for Alzheimer’s disease, in partnership with Altoida, Inc. [Hope Biosciences] Press Release

Five Ways China Must Cultivate Research Integrity

A swift increase in scientific productivity has outstripped the country’s ability to promote rigour and curb academic misconduct; it is time to seize solutions. [Nature News] Editorial

Elsevier Signs First Open-Access Deal in the United States

Publishing giant Elsevier has signed its first open-access deal with a US institution, Carnegie Mellon University (CMU) in Pittsburgh, Pennsylvania, Inside Higher Ed reports. The arrangement, which CMU announced on 21 November, will allow CMU scholars to publish articles in any Elsevier journal on an immediately free-to-read basis. [ScienceInsider] Editorial

NEW Advances in Stem Cells and Regenerative Medicine
March 8-11, 2020
Heidelberg, Germany

Visit our events page to see a complete list of events in the community.

NEW Faculty Positions – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Graduate Student Position – Stem Cell Biology (Technion – Israel Institute of Technology)

Researcher – Musculoskeletal Disorders (National University of Ireland Galway)

Postdoctoral Researcher – Embryonic and Adult Stem Cells (Yale University School of Medicine)

Faculty Position – Regenerative Medicine and Tissue Engineering (Columbia University)

Research Assistant – Stem Cells and Engineering (New York Blood Center)

Tenure-Track Positions – Biologic and Materials Sciences and Prosthodontics (University of Michigan)

Professor Positions – Biomedical Science (The Chinese University of Hong Kong)

Assistant Professor – Cell and Molecular Biology (Boston University)

Postdoctoral Researcher – Stem Cells (University of South Florida)

Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Mesenchymal Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.