Mesenchymal Cell News Volume 11.47 | Dec 3 2019

TOP STORY

Kartogenin Enhances the Therapeutic Effect of Bone Marrow Mesenchymal Stem Cells Derived Exosomes in Cartilage Repair

Researchers produced specific exosomes from bone marrow MSCs through kartogenin pre-conditioning and investigated their performance in either in vitro or in vivo experiments. [Nanomedicine] Abstract

(Ranked by impact factor of the journal)

IN VITRO

Heat Shock Pretreatment Improves Mesenchymal Stem Cell Viability by Heat Shock Proteins and Autophagy to Prevent Cisplatin-Induced Granulosa Cell Apoptosis

The authors investigated the mechanisms of heat shock pre-treatment on bone marrow MSCs (BMSCs) survival and the effects of heat shock-pretreated BMSCs on cisplatin-induced granulosa cell apoptosis. [Stem Cell Res Ther] Full Article

High Glucose Protects Mesenchymal Stem Cells from Metformin-Induced Apoptosis through the AMPK-Mediated mTOR Pathway

Investigators found that metformin induced MSC apoptosis during intensive glucose control, while high glucose significantly reversed its adverse effect in an AMPK-mTOR pathway dependent manner. [Sci Rep] Full Article

Adipose-Derived Mesenchymal Stem Cells Protect against CMS-Induced Depression-Like Behaviors in Mice via Regulating the Nrf2/HO-1 and TLR4/NF-κB Signaling Pathways

The authors explored whether the mechanism of anti-inflammatory activity of adipose-derived MSCs (ADSCs) was related to nuclear factor erythroid-2 related factor 2 (Nrf2). ADSCs were isolated from mouse fat pads and intravenously administered to chronic mild stress (CMS)-exposed C57BL/6 mice at the dose of 1×10⁶ once a week for three weeks. [Acta Pharmacol Sin] Abstract

The Characteristics of Mussel‐Inspired nHA/OSA Injectable Hydrogel and Repaired Bone Defect in Rabbit

Bone marrow MSCs were cocultured with hydrogels to investigate the cytotoxicity, proliferation, and osteogenic differentiation properties of the hydrogel. [J Biomed Mater Res B Appl Biomater] Abstract

Mesenchymal Stem Cells Alleviate Hydrochloric Acid-Induced Lung Injury through Suppression of Inflammation, Oxidative Stress and Apoptosis in Comparison to Moxifloxacin and Sildenafil

Researchers evaluated the protective role of MSCs, moxifloxacin, sildenafil or a combination of moxifloxacin and sildenafil against hydrochloric acid-induced acute lung injury. [Heliyon] Full Article

Effects of Nanofibers and Co-Culture with Endothelial Cells on Osteogenesis of Mesenchymal Stem Cells

Investigators fabricated polycaprolactone electrospun fibers with aligned and random morphology, co-cultured human MSCs with human umbilical endothelial cells, and investigated how these two factors modulate osteogenic differentiation of human MSCs. [Tissue Eng Part C Methods] Abstract

IN VIVO

Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models

Scientists provide the first comparative study of the therapeutic potential of allogeneic MSCs derived from bone marrow, adipose tissue, and dental pulp embedded in fibrin matrix, in small and large spinal cord injury models during subacute periods of spinal contusion. [Biomolecules] Abstract | Download Full Article

Alveolar Bone Repair of Rhesus Monkeys by Using BMP-2 Gene and Mesenchymal Stem Cells Loaded Three-Dimensional Printed Bioglass Scaffold

Researchers evaluated the osteogenesis of alveolar bone defects of animal in the following experimental groups: sham-operated, 3D printed bioglass (3D-BG), 3D-BG with BMP-2 gene loaded CS and 3D-BG with rhesus marrow bone MSCs and BMP/CS. [Sci Rep] Full Article

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Mesenchymal Stem Cell Perspective: Cell Biology to Clinical Progress

Developing further methods to understand and unlock MSC potential through intracellular and intercellular signaling, biomedical engineering, delivery methods and patient selection should all provide substantial advancements in the coming years and greater clinical opportunities. [npj Regen Med] Full Article

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Cyrus Biotechnology and the Broad Institute of MIT and Harvard Launch Multi-Target Collaboration to Develop Optimized CRISPR Gene Editing Technology

Cyrus Biotechnology, Inc. and the Broad Institute of MIT and Harvard have embarked on a scientific collaboration to optimize CRISPR for use in developing novel human therapeutics. [Cyrus Biotechnology, Inc.] Press Release

Boston Biomedical, Inc. Enters into an Alliance in Oncology Research with Columbia University, Harvard University and The Wistar Institute

Boston Biomedical, Inc. announced that the company has entered into an alliance in oncology research with three world-leading oncology centers of excellence – Columbia University, Harvard University and The Wistar Institute. [Boston Biomedical, Inc.] Press Release

Elsevier Progresses in Open-Access Deal Making

The scholarly publisher has announced several new licensing agreements in both Europe and the US, but some major academic groups are still without contracts and access to journals. [The Scientist] Editorial

NEW FGF Signaling: Understanding Function and Devising Therapeutic Tools
May 10-15, 2020
Lucca, Italy

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NEW Postdoctoral Position – Precision Sarcoma Research (German Cancer Research Center in the Helmholtz Association)

Faculty Positions – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Graduate Student Position – Stem Cell Biology (Technion – Israel Institute of Technology)

Researcher – Musculoskeletal Disorders (National University of Ireland Galway)

Postdoctoral Researcher – Embryonic and Adult Stem Cells (Yale University School of Medicine)

Faculty Position – Regenerative Medicine and Tissue Engineering (Columbia University)

Research Assistant – Stem Cells and Engineering (New York Blood Center)

Tenure-Track Positions – Biologic and Materials Sciences and Prosthodontics (University of Michigan)

Professor Positions – Biomedical Science (The Chinese University of Hong Kong)

Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

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