Mesenchymal Cell News 11.48 December 10, 2019 | |
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TOP STORYThe importance of macrophages in the pro-tumor role of gastric cancer-derived MSCs was observed in a mouse xenograft model with macrophage depletion. [Cell Death Dis] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROResearchers aimed to elucidate how cancer-educated bone marrow MSCs (BMSCs) promote the survival of cancer cells at primary tumor sites and distant sites. They highlight the dynamic change by identifying different gene expression signatures in intratumoral BMSCs and in BMSCs that move back in the bone marrow. [Cell Death Dis] Full Article Scientists hypothesized that zinc ion dynamics reflect insulin-producing cell (IPC) maturation status. Human adipose-derived stem cells were differentiated into IPCs by a two-step protocol using two-dimensional (2D) or 3D culture. [Sci Rep] Full Article The authors investigated mitochondrial biogenesis during the adipogenic, chondrogenic, and osteogenic differentiation of periosteum-derived MSCs (POMSCs). Both mitochondrial DNA contents and mitochondrial proteins were increased during all of these mesenchymal lineage differentiations of POMSCs. [Arch Pharm Res] Abstract Investigators evaluated a replacement strategy for the treatment of hepatocellular carcinoma via delivery of extracellular vesicles secreted from human adipose tissue-derived mesenchymal stromal/medicinal signaling cells genetically modified with a lentiviral vector expressing miR-125b with a specific ExoMotif sequence tag to enhance the loading into extracellular vesicles. [Cells] Full Article IN VIVOResearchers compared the effects of EGF, FGF2, and PDGFB on hematopoietic stem cell (HSC) regeneration using human MSCs that were transduced with these factors via lentiviral vectors. Among the above niche factors tested, MSCs transduced with PDGFB most significantly improved human HSC engraftment in immunodeficient mice. [Bone Marrow Transplant] Full Article A BMSCs‐Laden Quercetin/Duck’s Feet Collagen/Hydroxyapatite Sponge for Enhanced Bone Regeneration To assess the effect of quercetin on osteogenic differentiation, scientists cultured bone marrow MSCs (BMSCs) on sponges and evaluated by ALP, MTT assay, and RT‐PCR. Additionally, they were implanted into rat, and analyzed through Micro‐CT and histological staining. [J Biomed Mater Res A] Abstract Scientists utilized female SD rats with induced Hashimoto’s thyroiditis (HT) to evaluate the ability of transplanted MSCs to regulate Th17/Treg interactions in a rat HT model system. [Autoimmunity] Abstract The authors tracked ferumoxytol-labeled murine MSCs in murine osteoarthritis joints, and quantified changes to joint inflammation and fibrosis. [PLoS One] Full Article Investigators found that, compared with normal MSCs, co-cultured IL-13-MSCs suppressed the expression of pro-inflammatory factors and major histocompatibility complex II, promoted the expression of anti-inflammatory cytokines by activated retinal microglia (RMG) and simultaneously inhibited the proliferation of and phagocytosis by RMG. [Cell Mol Neurobiol] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSThe authors review the signaling mechanisms involved in adipogenesis and osteogenesis mediated by glucocorticoid receptor and discuss the factors that control the adipo-osteogenic balance. [Stem Cell Res Ther] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSCymerus™ MSCs Effective in Preclinical Model of Sepsis Cynata Therapeutics Limited announced that it has received positive efficacy data from preclinical studies of its Cymerus™ MSCs in a model of sepsis. [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] Press Release Adaptimmune Therapeutics plc announced that it has received Regenerative Medicine Advanced Therapy designation from the FDA for ADP-A2M4 for the treatment of synovial sarcoma. [Adaptimmune Therapeutics plc] Press Release | |
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POLICY NEWSProPublica Creates Database of Researchers’ Conflicts of Interest Over the past year, ProPublica has sought to highlight the potential conflicts of interest—professional relationships that might influence research, teaching, and other activities—of faculty members at public universities and research institutions and has created a database of professors’ corporate and nonprofit funding. [The Scientist] Editorial Tufts to Remove Sackler Name from Medical Campus Tufts University will not return donations from the family that made its riches on opioids, but the university will start a $3 million endowment for addiction prevention and treatment. [The Scientist] Editorial
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EVENTSNEW The Evolving Landscape of Cancer Modeling Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Position – Stem Cell Research (Yale University School of Medicine) NEW Research Fellow – Stem Cell Biology & Engineering (New York Blood Center) Graduate Student Position – Stem Cell Biology (Technion – Israel Institute of Technology) Researcher – Musculoskeletal Disorders (National University of Ireland Galway) Postdoctoral Researcher – Embryonic and Adult Stem Cells (Yale University School of Medicine) Faculty Position – Regenerative Medicine and Tissue Engineering (Columbia University) Research Assistant – Stem Cells and Engineering (New York Blood Center) Professor Positions – Biomedical Science (The Chinese University of Hong Kong) Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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