Mesenchymal Cell News Volume 11.49 | Dec 17 2019

TOP STORY

Transplantation of Mesenchymal Stem Cells Causes Long-Term Alleviation of Schizophrenia-Like Behavior Coupled with Increased Neurogenesis

Researchers utilized intracerebroventricular transplantation of bone marrow-derived MSCs as a means to enhance hippocampal neurogenesis in the ketamine-induced neurodevelopmental murine model for schizophrenia. [Mol Psychiatry] Abstract

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IN VITRO

Post-Production Modifications of Murine Mesenchymal Stem Cell (mMSC) Derived Extracellular Vesicles (EVs) and Impact on Their Cellular Interaction

Scientists performed a full physico-chemical, biochemical and biological characterization of mMSC-derived EVs. A stability study based on evaluating the colloidal behavior of obtained vesicles was performed in order to identify optimal storage conditions. [Biomaterials] Abstract

m⁶A Methylation of Precursor-miR-320/RUNX2 Controls Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells

Silence of METTL3 by siRNA decreased m⁶A methylation levels and inhibited osteogenic differentiation of BMSCs and reduced bone mass, and similar effects were observed in METTL3^+/- knockout mice. [Mol Ther Nucleic Acids] Abstract | Graphical Abstract

Hydroxylapatite‐Collagen Hybrid Scaffold Induces Human Adipose‐Derived Mesenchymal Stem Cells to Osteogenic Differentiation In Vitro and Bone Regrowth in Patients

The osteoinductivity properties of the hydroxylapatite‐collagen hybrid scaffold named Coll/Pro Osteon 200 were investigated in an in vitro model of human adipose MSCs, whereas the clinical evaluation was carried out in maxillofacial patients. [Stem Cells Transl Med] Full Article

Interaction of Material Stiffness and Negative Pressure to Enhance Differentiation of Bone Marrow Derived Stem Cells and Osteoblast Proliferation

Scientists investigated the response of osteoblasts and bone marrow derived MSCs to negative pressure and to determine whether a newly developed elastic osteomimetic bone repair material, a blend of type I collagen, chondroitin 6‐sulfate, and poly (octanediol citrate), could enhance the osteoblastic phenotype. [J Tissue Eng Regen Med] Abstract

Involvement of Mitochondrial Biogenesis during the Differentiation of Human Periosteum-Derived Mesenchymal Stem Cells into Adipocytes, Chondrocytes and Osteocytes

Researchers investigated mitochondrial biogenesis during the adipogenic, chondrogenic, and osteogenic differentiation of periosteum-derived MSCs (POMSCs). Both mitochondrial DNA contents and mitochondrial proteins were increased during all of these mesenchymal lineage differentiations of POMSCs. [Arch Pharm Res] Abstract

IN VIVO

The Secretome of Hypoxia Conditioned hMSC Loaded in a Central Depot Induces Chemotaxis and Angiogenesis in a Biomimetic Mineralized Collagen Bone Replacement Material

Angiogenic potential, determined by coculturing human umbilical vein endothelial cells with osteogenically induced human bone marrow MSCs showed prevascular structures, which sprouted throughout the interconnected pores in a hypoxia‐conditioned medium‐concentration‐dependent manner. [Adv Healthc Mater] Full Article

Delivery of Exogenous Proteins by Mesenchymal Stem Cells Attenuates Early Memory Deficits in a Murine Model of Alzheimer’s Disease

The authors used adenovirus-mediated gene transduction of bone marrow MSCs to deliver exogenous proteins into the brain of APPswe/PSEN1dE9 mice in the early stage of impairment. They observed that engrafted MSCs carrying exogenous ligand 1 alone reduced the production of the inflammatory cytokine TNF-ɑ and improved synapse-related protein expression but not cognitive function. [Neurobiol Aging] Abstract | Graphical Abstract

Cell-Based Interferon Gene Therapy Using Proliferation-Controllable, Interferon-Releasing Mesenchymal Stem Cells

Investigators tried to control the amount of murine interferon-γ (IFN-γ) secreted from transplanted murine MSC line C3H10T1/2 cells to achieve safe cell-based IFN-γ gene therapy for cancer. [Sci Rep] Full Article

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Stem-Cell Therapy for Bronchopulmonary Dysplasia

Clinical trials of MSC therapy for bronchopulmonary dysplasia are underway. A thorough understanding of the preclinical work that underpins these trials is critical for neonatal practitioners to properly evaluate them. [Curr Opin Pediatr] Abstract

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Salarius Pharmaceuticals Receives FDA Fast Track Designation for Lead Drug Candidate, Seclidemstat, in Relapsed or Refractory Ewing Sarcoma

Salarius Pharmaceuticals, Inc. announced that its lead investigational drug candidate, Seclidemstat, has been granted Fast Track Designation by the FDA for the treatment of patients with Ewing sarcoma who have relapsed or are refractory to standard-of-care therapy. [Salarius Pharmaceuticals, Inc.] Press Release

Oncternal Therapeutics Announces Opening of Phase Ib Expansion Cohort of Clinical Trial of TK216, Targeted ETS Inhibitor, in Patients with Ewing Sarcoma

Oncternal Therapeutics, Inc. announced that it has opened for enrollment a Phase Ib expansion cohort of its ongoing clinical trial evaluating TK216, a first-in-class, targeted, investigational small-molecule inhibitor of the E26 transformation-specific (ETS) family of oncoproteins, in patients with relapsed or refractory Ewing sarcoma. [Oncternal Therapeutics, Inc.] Press Release

Scientists on the Move

Success in science requires building top performing teams to push the boundaries of what is known—and this means attracting and nurturing scientific talent. In today’s political climate of possible scientific funding cuts and immigration policy uncertainty, headlines forecast a grim effect on scientific research. [Scientific American] Editorial

UK Election Dashes Scientists’ Hopes of Staying in the EU

The United Kingdom is now firmly on the path towards leaving the European Union, after the Conservative party won a majority of 79 seats in yesterday’s general election – a result that has major implications for science. [Nature News] Editorial

United States Drops Charges against Two More Scientists after Iran Prisoner Swap

US authorities have dropped charges against two researchers accused of attempting to export chemicals to Iran in violation of trade sanctions. The decision follows a prisoner swap in which the United States freed a third researcher who was charged alongside them – and imprisoned. [Nature News] Editorial

NEW Tissue Stem Cell Regulation by Autonomous and Non-Autonomous Mechanisms
October 9-14, 2020
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NEW Postdoctoral Researcher – Immuno-Oncology (Essen University Hospital)

Faculty Position – Stem Cell Research (Yale University School of Medicine)

Research Fellow – Stem Cell Biology & Engineering (New York Blood Center)

Faculty Positions – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Graduate Student Position – Stem Cell Biology (Technion – Israel Institute of Technology)

Researcher – Musculoskeletal Disorders (National University of Ireland Galway)

Postdoctoral Researcher – Embryonic and Adult Stem Cells (Yale University School of Medicine)

Faculty Position – Regenerative Medicine and Tissue Engineering (Columbia University)

Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

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