Mesenchymal Cell News 12.00 January 7, 2020 | |
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TOP STORYScientists showed that Pdgfra-expressing MSCs in uninjured digits established the regenerative blastema and were essential for regeneration. [Dev Cell] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROSuppression of chaperone-mediated autophagy (CMA) by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2 (LAMP-2A) in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation, and as expected, LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation. [Cell Mol Immunol] Full Article Enhancing the Efficacy of Stem Cell Therapy with Glycosaminoglycans Researchers showed that an fibroblast growth factor 2-binding heparan sulfate variant accelerated the expansion of freshly isolated bone marrow human MSCs without compromising their naivety. [Stem Cell Reports] Full Article Influence of Mesenchymal Stem Cell-Derived Extracellular Vesicles In Vitro and Their Role in Aging Incubation with young MSC-derived extracellular vesicles decreased the levels of aging markers and components of the mTOR pathway and increased the pluripotency markers from old MSC populations. [Stem Cell Res Ther] Full Article Long-term cultivation of placenta-derived-MSCs exhibited increases of senescent markers such as SA-β-gal and p21 including apoptotic factor, and decreases of proliferation, differentiation potential, and survival factor. [Stem Cell Res Ther] Full Article Scientists demonstrated major effects of MSC conditioned medium to reprogram macrophage immunometabolism through mTOR and PPARγ dependent and independent pathways. [Sci Rep] Full Article Human Mesenchymal Stem Cells Are Resistant to UV-B Irradiation MSCs exhibited higher clonogenic survival, proliferative activity and viability than dermal fibroblasts after exposure to UV-B irradiation. Cellular adhesion, morphology and expression of characteristic surface marker patterns remained largely unaffected in UV-irradiated MSCs. [Sci Rep] Full Article Human Lung Epithelial BEAS-2B Cells Exhibit Characteristics of Mesenchymal Stem Cells Both BEAS-2B and human umbilical cord-derived MSC 1 shared the same expression profile of surface markers of hMSCs and exhibited similar osteogenic and adipogenic differentiation potential. [PLoS One] Abstract IN VIVOMelatonin played a crucial role in bone balance, significantly accelerated the osteogenic differentiation of bone marrow MSCs (BMMSCs) by suppressing the MT2-dependent NF-κB signaling pathway, and downregulated osteoclastogenesis via receptor activator of nuclear factor-κB ligand paracrine secretion. [Br J Pharmacol] Abstract Investigators revealed that PDGF-BB significantly increased the proportion of PDGFR-β+ MSCs, and promoted both in vitro and in vivo viability, as well as nerve regenerative capacity and erectile function restoration of MSCs in rats. [Aging (Albany NY)] Full Article Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSAngiotensin Receptor Subtypes Regulate Adipose Tissue Renewal and Remodeling The authors summarize current data regarding the regulation of adipose tissue renewal and particularly adipose-derived mesenchymal stem/stromal cell adipogenic differentiation and secretory activity by renin‐angiotensin system, with an emphasis on AT2R and its effects. [FEBS J] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSMesoblast Limited announced that the FDA has confirmed receipt of Mesoblast’s filing of clinical efficacy and safety data for remestemcel-L in its rolling Biologics License Application for the treatment of children with steroid-refractory acute graft versus host disease. [Mesoblast Limited] Press Release Longeveron LLC announced that it has completed enrollment in its Phase I Alzheimer’s disease trial. This randomized, double-blind, placebo-controlled study is designed to evaluate the safety and efficacy of LMSCs in patients with mild Alzheimer’s disease. [Longeveron LLC (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSA Year after the Midterm Elections, Where Are They Now? November 2018 saw a wave of candidates from all walks of science-engineering, physics, medicine, and other life sciences-win first-time positions in the House, Senate, and state legislatures across the country. Of 20 STEM candidates running for Congressional seats that The Scientist counted last year, 10 won their races, the vast majority of them Democrats as well as political newcomers. [The Scientist] Editorial From Service to Science: NIH Shifts Focus of Mentoring Network Aimed at Boosting Grantee Diversity As co-director of graduate affairs at the University of Chicago, Nancy Schwartz spent the past four years helping faculty members at 15 major research universities become better mentors. The project was supported by the National Research Mentoring Network, a $23 million effort that the National Institutes of Health launched after discovering an embarrassing racial gap in who gets NIH grants. [ScienceInsider] Editorial
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EVENTSNEW Transplantation and Cellular Therapy Meetings of ASTCT and CIBMTR Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Senior Research Technician – Stem Cell Biology (Columbia University in the City of New York) NEW PhD Positions – Cell Biology (University of Warwick) NEW Postdoctoral Positions – Cell and Molecular Biology (University of Copenhagen) NEW PhD Student – Mammalian Development and Disease (Max Planck Institute for Molecular Genetics) NEW Postdoctoral Positions – Drug Delivery and Therapeutic Development (University of Minnesota) Postdoctoral Researcher – Immuno-Oncology (Essen University Hospital) Research Fellow – Stem Cell Biology & Engineering (New York Blood Center) Graduate Student Position – Stem Cell Biology (Technion – Israel Institute of Technology) Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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