Mesenchymal Cell News 12.05 February 11, 2020 | |
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TOP STORYScientists showed that the level of N6 methyladenosine mRNA modifications was decreased, and the autophagic flux was increased in nucleus pulposus cells under compression when they were cocultured with bone-derived MSCs. [Cell Death Dis] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROTo develop a better understanding of the biological functions of stem cells from the apical papilla (SCAP) and bone marrow MSCs (BMMSCs), researchers compared and analyzed the PIWI-interacting RNA (piRNA) expression profiles of the exosomes derived from human SCAP and the exosomes of BMMSCs. [Stem Cells Dev] Abstract Investigators identified the differential expression of circular RNA (circRNA), miRNA, and piwi-interacting RNA (piRNA) after lineage commitment towards osteo- and chondrogenesis of human bone marrow MSCs. [Cells] Abstract | Download Full Article The authors investigated cycloastragenol’s ability to promote cell proliferation, maintain cells in their stable active phenotype, and support the production of cartilaginous extracellular matrix in human adipose-derived MSCs in up to 28 days of three-dimensional chondrogenic culture. [Cells] Abstract | Download Full Article IN VIVOA nanoparticle for computed tomography (CT)/fluorescence dual-modal imaging, Au@Albumin@ICG@PLL, was developed to track bone marrow-derived MSCs that were administered intratracheally into mice with silica-induced pulmonary fibrosis, which facilitated the understanding of the therapeutic effect and the possible molecular mechanism of stem cell therapy. [J Mater Chem B] Abstract Researchers evaluated the production of cytotoxic allo-antibodies directed against donor’s ELA in mismatched and halfmatched horses receiving repeated intra-articular administration of stimulated MSCs and unstimulated MSCs in pathologic joints. [Stem Cell Res Ther] Full Article Investigators delivered MSCs via intrathecal (IT) route to two boys with rapidly advancing cerebral adrenoleukodystrophy. The first boy received three doses one week apart, whereas the second boy received a single dose of IT MSCs. [Stem Cells Transl Med] Full Article The authors investigated whether extracellular vesicles (EVs) obtained by stimulating inflammatory cytokines on canine adipose MSCs improved anti-inflammatory and/or immunosuppressive potential of EVs, and/or their ability to alleviate inflammation in colitis. [Sci Rep] Full Article Researchers assessed the potential of cell-scaffold constructs for the regeneration of extensive mandibular bone defects in a minipig model. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSThe authors compare the different types of dental derived MSCs, highlight the isolation technique, the characteristics, and the therapeutic potential of human periapical cyst-MSCs. [Mol Biol Rep] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSBrainStorm Cell Therapeutics, Inc. announced that the company recently held a high level meeting with the FDA to discuss potential NurOwn® regulatory pathways for approval in ALS. [BrainStorm Cell Therapeutics, Inc.] Press Release Mesoblast Submits Completed Biologics License Application for Ryoncil™ to US FDA Mesoblast Limited announced that it has submitted its completed Biologics License Application to the FDA for Ryoncil™, its lead allogeneic cell therapy for the treatment of children with steroid-refractory acute graft versus host disease. [Mesoblast Limited] Press Release | |
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POLICY NEWSTrump’s 2021 Budget Drowns Science Agencies in Red Ink, Again It’s another sea of red ink for federal research funding programs in President Donald Trump’s latest budget proposal. The 2021 budget request to Congress released February 10th calls for deep, often double-digit cuts to R&D spending at major science agencies. [ScienceInsider] Editorial Major Cancer Institute Sued by Its Own Researchers over ‘Tapering’ Funding Alleging that a leading cancer funder is slashing their support in an “unethical and reckless” way, six prominent cancer researchers at the University of California, San Diego, have filed a lawsuit to compel it to continue its current level of support. [ScienceInsider] Editorial
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EVENTSNEW First International STEMNET Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Research Fellowship – Autism Disease Modeling (Black Family Stem Cell Institute) Postdoctoral Fellowship – Stem Cell Niche Biology (University of California, San Francisco) Postdoctoral Fellow – Cardiovascular Research (Temple University) Postdoctoral Associate – Cartilage Regeneration (Drexel University) Postdoctoral Scholar – Corneal Stem Cells (University of California, Los Angeles) Senior Research Technician – Stem Cell Biology (Columbia University in the City of New York) PhD Positions – Cell Biology (University of Warwick) Postdoctoral Positions – Cell and Molecular Biology (University of Copenhagen) Postdoctoral Positions – Drug Delivery and Therapeutic Development (University of Minnesota) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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