Mesenchymal Cell News 12.10 March 17, 2020 | |
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TOP STORYAn Engineered Cell-Laden Adhesive Hydrogel Promotes Craniofacial Bone Tissue Regeneration in Rats In a well-established rat peri-implantitis model, application of the adhesive hydrogel encapsulating gingival MSCs resulted in complete bone regeneration around ailing dental implants with peri-implant bone loss. [Sci Transl Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROResearchers examined if and how prolyl hydroxylase 2 silencing enhanced the paracrine effects of bone marrow-derived MSCs on necrotizing enterocolitis. [Cell Death Dis] Full Article Investigators identified 132 lncRNAs, 114 miRNAs, and 172 mRNAs were differentially expressed. Gene ontology analysis demonstrated that regulation of the neurogenic locus notch homolog, Wnt, and epidermal growth factor receptor signaling pathways and activation of mitogen-activated protein kinase activity were related to odontogenic differentiation. [Stem Cell Res Ther] Full Article Researchers found that the loss of osteocalcin and osteopontin reduced stem cells self-renewal potential and multipotency, affected their differentiation into an osteogenic lineage, and impaired their angiogenic potential while maintaining chondrogenic and adipogenic lineages. [J Cell Physiol] Abstract 40°C-exposure altered cellular morphology with significant cell flattening, delayed cell-matrix de-adhesion response and slowered migration of MSCs, accompanied by suppressed directionality ratio and cell trajectory. [Sci Rep] Full Article Adipose-derived extracellular vesicles (EVs) promoted human umbilical vein endothelial cell (HUVEC) tube formation significantly more than bone marrow-derived EVs, while also maximizing HUVEC mitochondria function. [J Trauma Acute Care Surg] Abstract IN VIVOThe authors demonstrated a pathway through which MSCs instructed macrophages to resolve inflammation and preserve tissue-specific stem cells, leading to homeostasis in mice with autoimmune uveoretinitis and sterile-injury-induced corneal epithelial stem cell deficiency. [Cell Rep] Full Article | Graphical Abstract To determine whether MSC co-transplantation could reduce immune rejection after allogeneic induced pluripotent stem cell-derived cardiomyocyte transplantation, the latter cell type, harboring a luciferase transgene, was subcutaneously transplanted alone or together with syngeneic MSCs into BALB/c mice. [Sci Rep] Full Article Magnetic resonance imaging showed that animals treated with human umbilical cord Wharton’s jelly-derived MSCs after moderate intracerebral hemorrhage (ICH) had smaller residual hematoma volumes than vehicle-treated rats, whereas the cell therapy failed to decrease the hematoma volume in animals with a severe ICH. [Stem Cells Dev] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSAdipose-Derived Stromal Cells in Regulation of Hematopoiesis Scientists focus on the properties of adipose-derived stromal cells (ASCs) in hematopoietic regulation and the underlying mechanisms, as well as the current applications and future perspectives in ASC-based therapy. [Cell Mol Biol Lett] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSPluristem Therapeutics Inc. announced it has signed a collaborative agreement with the BIH Center for Regenerative Therapy and the Berlin Center for Advanced Therapies at Charite’ University of Medicine Berlin to expand its existing framework and research agreement and conduct a joint project evaluating the therapeutic effects of Pluristem’s patented PLX cell product candidates for potential treatment of the respiratory and inflammatory complications associated with the COVID-19 coronavirus. [Pluristem Therapeutics Inc.] Press Release Celltex Therapeutics Corporation announced that it has begun active discussions with the FDA regarding a study using MSCs against coronavirus-type symptoms. [Celltex Therapeutics Corporation (Business Wire, Inc.)] Press Release | |
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POLICY NEWSJournals, Peer Reviewers Cope with Surge in COVID-19 Publications Academic journals have already taken steps to accelerate the flow of peer-reviewed information by expediting editorial and peer review for coronavirus-related manuscripts and granting them open-access status upon publication. [The Scientist] Editorial Near-Lockdown in the Bay Area ‘Ratchets Up’ Challenges for Local Biotechs and Labs Seven counties in the San Francisco Bay Area went into near-lockdown — ushering in a new reality for biopharma companies and biomedical labs. The “shelter in place” order offers significant leeway for medical research. [STAT News] Editorial
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EVENTSNEW From Stem Cells to Human Development Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Bone Repair (Johns Hopkins University School of Medicine) Research Specialist – Stem Cells for Regenerative Medicine (University of Illinois at Chicago) Postdoctoral Associate – IDH Pathways in Sarcomas (University of Miami) Postdoctoral Associate – Stem Cell Research (University of Miami Health System) Postdoctoral Scholar – Cancer Research in Sarcoma (The Ohio State University) Postdoctoral Research Fellowship – Autism Disease Modeling (Black Family Stem Cell Institute) Postdoctoral Fellowship – Stem Cell Niche Biology (University of California, San Francisco) Postdoctoral Associate – Cartilage Regeneration (Drexel University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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